1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders

Autor: Ondrej Benek, Lukas Hroch, Laura Aitken, Frank Gunn-Moore, Lucie Vinklarova, Kamil Kuca, Daniel I. Perez, Concepcion Perez, Ana Martinez, Zdenek Fisar, Kamil Musilek

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 665-670 (2018)

Several neurodegenerative disorders including Alzheimer’s disease (AD) have been connected with deregulation of casein kinase 1 (CK1) activity. Inhibition of CK1 therefore presents a potential therapeutic strategy against such pathologies. Recently

Externí odkaz: https://doaj.org/article/e6a3739db0ac4249892a19629268c016

Novel Benzothiazole-Based Ureas as 17β-HSD10 Inhibitors, A Potential Alzheimer’s Disease Treatment

Autor: Laura Aitken, Ondrej Benek, Brogan E. McKelvie, Rebecca E. Hughes, Lukas Hroch, Monika Schmidt, Louise L. Major, Lucie Vinklarova, Kamil Kuca, Terry K. Smith, Kamil Musilek, Frank J. Gunn-Moore

Publikováno v: Molecules, Vol 24, Iss 15, p 2757 (2019)

It has long been established that mitochondrial dysfunction in Alzheimer’s disease (AD) patients can trigger pathological changes in cell metabolism by altering metabolic enzymes such as the mitochondrial 17β-hydroxysteroid dehydrogenase type 10 (

Externí odkaz: https://doaj.org/article/c039f8abf9114eae9e6a20208c4c6e80

1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders

Autor: Concepción Pérez, Daniel I. Perez, Zdenek Fisar, Lukas Hroch, Ondrej Benek, Kamil Kuca, Frank J. Gunn-Moore, Kamil Musilek, Ana Martínez, Laura Aitken, Lucie Vinklarova

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 665-670 (2018)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Enzyme Inhibition and Medicinal Chemistry

6 p.-2 fig.-2 tab. Benek, O. et al.
Several neurodegenerative disorders including Alzheimer's disease (AD) have been connected with deregulation of casein kinase 1 (CK1) activity. Inhibition of CK1 therefore presents a potential therapeutic stra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165ba45be77aced7ee46436b66b4ee64
https://doi.org/10.1080/14756366.2018.1445736

Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17β-HSD10 with Implications to Alzheimer’s Disease Treatment

Autor: Daniel Jun, Antonín Lyčka, Kamil Musilek, Lukas Hroch, Frank J. Gunn-Moore, Lucie Zemanová, Ondrej Benek, Rafael Dolezal, Monika Schmidt, Lucie Vinklarova, Vendula Kralova, Laura Aitken, Matej Chribek, Lukas Prchal, Martina Hrabinova, Kamil Kuca

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 6, p 2059 (2020)
Volume 21
Issue 6

Human 17&beta
hydroxysteroid dehydrogenase type 10 is a multifunctional protein involved in many enzymatic and structural processes within mitochondria. This enzyme was suggested to be involved in several neurological diseases, e.g., mental reta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72150969846b1ef194896d2836e2df59
https://doi.org/10.3390/ijms21062059