PLK-1 promotes the merger of the parental genome into a single nucleus by triggering lamina disassembly

Autor: Griselda Velez-Aguilera, Sylvia Nkombo Nkoula, Batool Ossareh-Nazari, Jana Link, Dimitra Paouneskou, Lucie Van Hove, Nicolas Joly, Nicolas Tavernier, Jean-Marc Verbavatz, Verena Jantsch, Lionel Pintard

Publikováno v: eLife, Vol 9 (2020)

Life of sexually reproducing organisms starts with the fusion of the haploid egg and sperm gametes to form the genome of a new diploid organism. Using the newly fertilized Caenorhabditis elegans zygote, we show that the mitotic Polo-like kinase PLK-1

Externí odkaz: https://doaj.org/article/2a846be5f188463186513102ddc7b563

Mechanisms of Nuclear Pore Complex disassembly by the mitotic Polo-Like Kinase 1 (PLK-1) in C. elegans embryos

Autor: Sylvia Nkombo Nkoula, Griselda Velez-Aguilera, Batool Ossareh-Nazari, Lucie Van Hove, Cristina Ayuso, Véronique Legros, Guillaume Chevreux, Laura Thomas, Géraldine Seydoux, Peter Askjaer, Lionel Pintard

Publikováno v: bioRxiv

The nuclear envelope, which protects and organizes the interphase genome, is dismantled during mitosis. In theC. eleganszygote, nuclear envelope breakdown (NEBD) of the parental pronuclei is spatially and temporally regulated during mitosis to promot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7bbb8da18173fdda4744e2781a1d4c
https://europepmc.org/articles/PMC9980100/

Cortical microtubule pulling forces contribute to the union of the parental genomes in the

Autor: Griselda, Velez-Aguilera, Batool, Ossareh-Nazari, Lucie, Van Hove, Nicolas, Joly, Lionel, Pintard

Publikováno v: eLife. 11

Previously, we reported that the Polo-like kinase PLK-1 phosphorylates the single

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0a2e6b21ca20c67400466190f6b81325
https://pubmed.ncbi.nlm.nih.gov/35259092

PLK-1 promotes the merger of the parental genome into a single nucleus by triggering lamina disassembly

Autor: Nicolas Joly, Nicolas Tavernier, Sylvia Nkombo Nkoula, Jean-Marc Verbavatz, Verena Jantsch, Lionel Pintard, Jana Link, Griselda Velez-Aguilera, Batool Ossareh-Nazari, Lucie Van Hove, Dimitra Paouneskou

Publikováno v: eLife
eLife, Vol 9 (2020)
eLife, eLife Sciences Publication, 2020, 9, ⟨10.7554/elife.59510⟩

Life of sexually reproducing organisms starts with the fusion of the haploid egg and sperm gametes to form the genome of a new diploid organism. Using the newly fertilizedCaenorhabditis eleganszygote, we show that the mitotic Polo-like kinase PLK-1 p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5558ecc22bedf5c05e381dd948f48fe1
https://pubmed.ncbi.nlm.nih.gov/33030429

Cdk1 phosphorylates SPAT-1/Bora to trigger PLK-1 activation and drive mitotic entry in C. elegans embryos

Autor: Anna Noatynska, Nicolas Tavernier, Lionel Pintard, Monica Gotta, Lisa Martino, Françoise Schwager, Thibaut Léger, Costanza Panbianco, Lucie Van Hove

Publikováno v: The Journal of cell biology
Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2015, 208 (6), pp.661-9. ⟨10.1083/jcb.201408064⟩
The Journal of Cell Biology
The Journal of Cell Biology, Vol. 208, No 6 (2015) pp. 661-9

Phosphorylation of SPAT-1/Bora by Cdk1 enhances Plk1 phosphorylation by Aurora A and promotes entry into mitosis in C. elegans.
The molecular mechanisms governing mitotic entry during animal development are incompletely understood. Here, we show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c568a1d763b5e312b17aff179bd05528