Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Lucie Valek"'
Autor:
Bao Ngoc Tran, Lucie Valek, Annett Wilken-Schmitz, Dominik Christian Fuhrmann, Dimitry Namgaladze, Ilka Wittig, Irmgard Tegeder
Publikováno v:
Redox Biology, Vol 45, Iss , Pp 102054- (2021)
Nucleoredoxin is a thioredoxin-like redoxin that has been recognized as redox modulator of WNT signaling. Using a Yeast-2-Hybrid screen, we identified calcium calmodulin kinase 2a, Camk2a, as a prominent prey in a brain library. Camk2a is crucial for
Externí odkaz:
https://doaj.org/article/bfa50570eabc4019b5ac0b9f650d83b1
Publikováno v:
Redox Biology, Vol 20, Iss , Pp 217-235 (2019)
Upregulations of neuronal nitric oxide synthase (nNOS) in the rodent brain have been associated with neuronal aging. To address underlying mechanisms we generated SH-SY5Y neuronal cells constitutively expressing nNOS at a level similar to mouse brain
Externí odkaz:
https://doaj.org/article/9708f29cfdbd45008935ce4f0a0842ad
Publikováno v:
Data in Brief, Vol 21, Iss , Pp 1302-1308 (2018)
Upregulations of neuronal nitric oxide synthase (nNOS/NOS1) in the mouse brain upon aging and stress suggest a role of NO-dependent redox protein modifications for age-associated protein imbalances or dysfunctions. We generated a cell model, in which
Externí odkaz:
https://doaj.org/article/cda77c2e836b43be9b4af3584c3cf18c
Publikováno v:
Data in Brief, Vol 21, Iss , Pp 1309-1314 (2018)
Upregulations of neuronal nitric oxide synthase (nNOS/NOS1) in the mouse brain upon aging suggest a role in age-associated changes of protein homeostasis. We generated a cell model, in which constitutive expression of nNOS in SH-SY5Y cells at a level
Externí odkaz:
https://doaj.org/article/99cc909836ef46ef892bc2fb7b5985e2
Autor:
Lucie Valek, Irmgard Tegeder
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9496 (2021)
Rodent models of Parkinson’s disease are based on transgenic expression of mutant synuclein, deletion of PD genes, injections of MPTP or rotenone, or seeding of synuclein fibrils. The models show histopathologic features of PD such as Lewi bodies b
Externí odkaz:
https://doaj.org/article/fc9b6a9033d44f33ab8ce3ec2b780dbe
Autor:
Sylvia Torres-Odio, Jana Key, Hans-Hermann Hoepken, Júlia Canet-Pons, Lucie Valek, Bastian Roller, Michael Walter, Blas Morales-Gordo, David Meierhofer, Patrick N. Harter, Michel Mittelbronn, Irmgard Tegeder, Suzana Gispert, Georg Auburger
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-26 (2017)
Abstract Background PINK1 deficiency causes the autosomal recessive PARK6 variant of Parkinson’s disease. PINK1 activates ubiquitin by phosphorylation and cooperates with the downstream ubiquitin ligase PARKIN, to exert quality control and control
Externí odkaz:
https://doaj.org/article/37f1030eeb624662a92964439fd188fb
Publikováno v:
Redox Biology, Vol 11, Iss , Pp 176-191 (2017)
Cyclic GMP-dependent protein kinase 1 (PKG1) mediates presynaptic nociceptive long-term potentiation (LTP) in the spinal cord and contributes to inflammatory pain in rodents but the present study revealed opposite effects in the context of neuropathi
Externí odkaz:
https://doaj.org/article/cefce92198ae42588e311dc9d7b04951
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 6 (2019)
Parkinson's disease (PD) often manifests with prodromal pain and sensory losses whose etiologies are not well understood. Multiple genetic and toxicity-based rodent models of PD partly recapitulate the histopathology and motor function deficits. Alth
Externí odkaz:
https://doaj.org/article/8d9b91c12c944e1da68a2f11c3408e30
Autor:
Lucie Valek, Irmgard Tegeder
Publikováno v:
Antioxidants, Vol 10, Iss 3, p 449 (2021)
Nucleoredoxin (NXN) is a redox regulator of Disheveled and thereby of WNT signaling. Deficiency in mice leads to cranial dysmorphisms and defects of heart, brain, and bone, suggesting defects of cell fate determination. We used shRNA-mediated knockdo
Externí odkaz:
https://doaj.org/article/165823b9e22640278c8f442b5704ccf0
Publikováno v:
Data in Brief, Vol 5, Iss C, Pp 834-845 (2015)
Injury of the sciatic nerve results in regulations of pro- and anti-oxidative enzymes at sites of nociceptive signaling including the injured nerve, dorsal root ganglia (DRGs), dorsal horn of the spinal cord, thalamus and somatosensory cortex (Valek
Externí odkaz:
https://doaj.org/article/6c0bb8c96063417aa9ea45fe7e3ab700