Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lucie Leveque-El Mouttie"'
Autor:
Matthew Burge, David Goldstein, Andrew Haydon, Nick Pavlakis, Charlotte Lemech, Edward Hammond, Darryn Bampton, Keith Dredge, Michael P Brown, Andrew Clouston, Nigel J Waterhouse, Amanda C Stanley, Lucie Leveque-El Mouttie, Grace M Chojnowski
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 1 (2023)
Background Pixatimod is a unique activator of the Toll-like Receptor 9 pathway. This phase I trial evaluated safety, efficacy and pharmacodynamics of pixatimod and PD-1 inhibitor nivolumab in immunologically cold cancers.Methods 3+3 dose escalation w
Externí odkaz:
https://doaj.org/article/9084358ebd5841eb853afac834f15155
Autor:
Amy H. Porter, Lucie Leveque-El Mouttie, Therese Vu, Claudia Bruedigam, Joanne Sutton, Sebastien Jacquelin, Geoffrey R. Hill, Kelli P.A. MacDonald, Steven W. Lane
Publikováno v:
Haematologica, Vol 102, Iss 9 (2017)
Externí odkaz:
https://doaj.org/article/bfb6216dd8994ece9bc46fc67309fdeb
Autor:
Charlotte Lemech, Keith Dredge, Darryn Bampton, Edward Hammond, Andrew Clouston, Nigel J Waterhouse, Amanda C Stanley, Lucie Leveque-El Mouttie, Grace M Chojnowski, Andrew Haydon, Nick Pavlakis, Matthew Burge, Michael P Brown, David Goldstein
Publikováno v:
Journal for ImmunoTherapy of Cancer. 11:e006136
BackgroundPixatimod is a unique activator of the Toll-like Receptor 9 pathway. This phase I trial evaluated safety, efficacy and pharmacodynamics of pixatimod and PD-1 inhibitor nivolumab in immunologically cold cancers.Methods3+3 dose escalation wit
Autor:
Lucie Leveque-El Mouttie, Therese Vu, Claudia Bruedigam, Kelli P. A. MacDonald, Geoffrey R. Hill, Steven W. Lane, Amy H. Porter, Sebastien Jacquelin, Joanne Sutton
Publikováno v:
Haematologica. 102:e344-e347
Autor:
Lucie Leveque-El Mouttie, Kylie A. Alexander, Melody Cheong, Kelli P. A. MacDonald, Kate A. Markey, Katie E. Lineburg, Bianca E. Teal, Bruce R. Blazar, Motoko Koyama, Rachel D. Kuns, Andrew D. Clouston, Geoffrey R. Hill, Laetitia Le Texier
Publikováno v:
Blood. 128:794-804
Chronic graft-versus-host disease (cGVHD) is a major cause of late mortality following allogeneic bone marrow transplantation (BMT) and is characterized by tissue fibrosis manifesting as scleroderma and bronchiolitis obliterans. The development of ac
Autor:
Ping Zhang, Bianca E. Teal, Rachel D. Kuns, Antiopi Varelias, Kelli P. A. MacDonald, Mark D. Bunting, Katie E. Lineburg, Christian R. Engwerda, Shaun R. McColl, Leesa F. Wockner, Kelly R. Locke, Kate A. Markey, Gabrielle T. Belz, Geoffrey R. Hill, Kate H. Gartlan, Motoko Koyama, Slavica Vuckovic, Lucie Leveque-El Mouttie, Melody Cheong, Michele W.L. Teng, Siok-Keen Tey, Mark J. Smyth
Publikováno v:
The Journal of Experimental Medicine
Koyama et al. show that GVHD markedly enhances alloantigen presentation within the mesenteric lymph nodes, mediated by donor CD103+CD11b− DCs that migrate from the colon under the influence of CCR7. This antigen presentation imprints gut-homing int
Autor:
Rachel D. Kuns, Benjamin Cao, Kylie A. Alexander, Charis E Teh, Katie E. Lineburg, Jemma Nicholls, Laetitia Le Texier, Michele Teng, Bianca E. Teal, Bruce R. Blazar, Kelli P. A. MacDonald, Geoffrey R. Hill, Steven W. Lane, Stephen J. Blake, Michelle Melino, Susan K. Nilsson, Andrew D. Clouston, Lucie Leveque-El Mouttie, Fernando Souza-Fonseca-Guimaraes, Christian R. Engwerda, Cameron McDonald-Hyman, Daniel H.D. Gray, Blessy C. Nalkurthi
Publikováno v:
JCI insight. 1(15)
Regulatory T cells (Tregs) play a crucial role in the maintenance of peripheral tolerance. Quantitative and/or qualitative defects in Tregs result in diseases such as autoimmunity, allergy, malignancy, and graft-versus-host disease (GVHD), a serious
Autor:
Claudia Bruedigam, Geoffrey R. Hill, Steven W. Lane, Kelli P. A. MacDonald, Lucie Leveque-El Mouttie, Glen M. Boyle, Mary Lor, Justine D. Mintern, Rachel D. Kuns, Katie E. Lineburg, Therese Vu, Frederik Otzen Bagger, Bianca E. Teal
Publikováno v:
Blood. 125(19)
Granulocyte colony-stimulating factor (G-CSF) is widely used clinically to prevent neutropenia after cytotoxic chemotherapy and to mobilize hematopoietic stem cells (HSCs) for transplantation. Autophagy, a process of cytoplasmic component recycling,
Autor:
Geoffrey R. Hill, Laetitia Le Texier, Lucie Leveque-El Mouttie, Kelli P. A. MacDonald, Rachel D. Kuns, Bianca E. Teal, Katie E. Lineburg
Publikováno v:
Blood. 126:34-34
Stem cell transplantation (SCT) is the only curative therapy for the majority of hematological malignancies and relies on successful engraftment of donor hematopoietic stem cells (HSC) to reconstitute the patient's hematopoiesis and immunity. Graft-v
Autor:
Melody Cheong, Kate Gartlan, Siok-Keen Tey, Rachel Kuns, Mary Lor, Katie Lineburg, Bianca Teal, Wei Shi, Jyothy Raju, Ping Zhang, Antiopi Varelias, Lucie Leveque-El Mouttie, Stuart Olver, Mark Bunting, Steven Lane, Glen Boyle, Jenny Ting, Kate Schroder, Christian Engwerda, Kum Kum Khanna, Mark Smyth, Kelli MacDonald, Motoko Koyama, Geoffrey Hill
Publikováno v:
The Journal of Immunology. 194:140.33-140.33
The adaptor protein ASC is known to facilitate caspase-1 activation essential for innate host immunity via the formation of the inflammasome complex - a multi-protein structure responsible for processing IL-1b and IL-18 to their active moieties. Here