Development of an LC-MS multivariate nontargeted methodology for differential analysis of the peptide profile of Asian hornet venom (Vespa velutina nigrithorax): application to the investigation of the impact of collection period variation

Autor: Benoît Maunit, Patrick Baril, Cyril Colas, David Da Silva, Eric Darrouzet, Thao Nhi Le, Lucie Leseurre

Publikováno v: Analytical and Bioanalytical Chemistry
Analytical and Bioanalytical Chemistry, Springer Verlag, 2020, 412 (6), pp.1419-1430. ⟨10.1007/s00216-019-02372-2⟩
Analytical and Bioanalytical Chemistry, 2020, 412 (6), pp.1419-1430. ⟨10.1007/s00216-019-02372-2⟩

International audience; Insect venom is a highly complex mixture of bioactive compounds, containing proteins, peptides, and small molecules. Environmental factors can alter the venom composition and lead to intraspecific variation in its bioactivity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc555f0141fed249d21edd01e6b4431
https://hal-univ-tours.archives-ouvertes.fr/hal-02794337

Synthesis of atropisomeric chiral MeOBIPHEP analogues via Pd-catalyzed P–C coupling — applications to asymmetric Rh-catalyzed C–C bond formations in water

Autor: Anthony Millet, Jean‐Pierre Genet, Florent Le Boucher d’Herouville, Véronique Michelet, Michelangelo Scalone, Lucie Leseurre

Publikováno v: Catalysis Communications. 69:129-132

The preparation and catalytic applications of water-soluble MeOBIPHEP-based atropisomeric chiral congener ligands are described. The optimization of the catalytic system to promote the key P–C coupling revealed the superiority of palladium catalyst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8e83438f9db84421fc8d95bc25f8f51
https://doi.org/10.1016/j.catcom.2015.06.005

Synthesis of New Water-Soluble Atropisomeric Ligands Derived from the MeOBIPHEP Skeleton: Applications for Asymmetric CH Bond Formation and Mechanistic Studies

Autor: Kurt Püntener, Lucie Leseurre, Michelangelo Scalone, Véronique Michelet, Jean-Pierre Genêt

Publikováno v: Advanced Synthesis & Catalysis. 353:3269-3277

We have extended the methodology developed for the preparation of atropisomeric chiral ligands derived from the MeOBIPHEP ligand to water-soluble ones. The hydrophilic ligands bearing sodium carboxylate and methylammonium chloride moieties were easil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a9db8807b8ab1894c97aebe0a26199c
https://doi.org/10.1002/adsc.201100535

Efficient Route to Atropisomeric Ligands – Application to the Synthesis of MeOBIPHEP Analogues

Autor: Kurt Püntener, Jean-Pierre Genêt, Michelangelo Scalone, Véronique Michelet, Florent Le Boucher d'Herouville, Lucie Leseurre

Publikováno v: Organic Letters. 13:3250-3253

A highly efficient Pd-catalyzed P-C coupling reaction of easily accessible atropisomeric bisphosphane is described in the presence of various electron-poor aromatic iodides. The reactions are conducted in the presence of a Pd(II)/dppf catalyst in ace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed40a33a5ab0a8b643d1f376aaabd208
https://doi.org/10.1021/ol2011874

Gold-Catalyzed Hydroxy- and Alkoxycyclization of Functionalized Enynes

Autor: Jean-Pierre Genêt, Véronique Michelet, Emilie Genin, Lucie Leseurre, Patrick Y. Toullec

Publikováno v: Synlett. 2007:1780-1784

A general Au III catalytic system is described for the efficient hydroxy- and alkoxycyclization reactions of 1,6-enynes. The reactions lead to carbo- and heterocyclic alcohols or ethers in good to excellent yields. The cyclizations are conducted in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6ab1295bcfba48ecaaff331559d5e0
https://doi.org/10.1055/s-2007-982570