Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lucie Laurien"'
Autor:
Lucie Laurien, Masahiro Nagata, Hannah Schünke, Tom Delanghe, Janica L. Wiederstein, Snehlata Kumari, Robin Schwarzer, Teresa Corona, Marcus Krüger, Mathieu J. M. Bertrand, Vangelis Kondylis, Manolis Pasparakis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Receptor interacting protein kinase 1 (RIPK1) regulates cell death and inflammatory responses. Here the authors show that autophosphorylation at Ser166 is required for RIPK1-mediated cell death and inflammation in mouse models of inflammatory patholo
Externí odkaz:
https://doaj.org/article/2d82135048944fbfa5ea87adae76d9b0
Autor:
Alessandro Torgovnick, Jan Michel Heger, Vasiliki Liaki, Jörg Isensee, Anna Schmitt, Gero Knittel, Arina Riabinska, Filippo Beleggia, Lucie Laurien, Uschi Leeser, Christian Jüngst, Florian Siedek, Wenzel Vogel, Niklas Klümper, Hendrik Nolte, Maike Wittersheim, Lars Tharun, Roberta Castiglione, Marcus Krüger, Astrid Schauss, Sven Perner, Manolis Pasparakis, Reinhard Büttner, Thorsten Persigehl, Tim Hucho, Grit Sophie Herter-Sprie, Björn Schumacher, Hans Christian Reinhardt
Publikováno v:
Cell Reports, Vol 25, Iss 4, Pp 1027-1039.e6 (2018)
Summary: Cdkn1a, which encodes p21, functions as a major route for p53-mediated cell-cycle arrest. However, the consequence of Cdkn1a gene dosage on tumor suppression has not been systematically investigated. Here, we employed BAC transgenesis to gen
Externí odkaz:
https://doaj.org/article/662c648938254acfa54677dfa23bd2fb
Publikováno v:
Current Opinion in Cell Biology
Necroptosis and pyroptosis are inflammatory forms of regulated necrotic cell death as opposed to apoptosis that is generally considered immunologically silent. Recent studies revealed unexpected links in the pathways regulating and executing cell dea
Autor:
Filippo Beleggia, Hendrik Nolte, Niklas Klümper, Vasiliki Liaki, Hans Christian Reinhardt, Lars Tharun, Alessandro Torgovnick, Florian Siedek, Sven Perner, Jörg Isensee, Jan Michel Heger, Lucie Laurien, Gero Knittel, Maike Wittersheim, Reinhard Büttner, Anna Schmitt, Manolis Pasparakis, Arina Riabinska, Uschi Leeser, Wenzel Vogel, Christian Jüngst, Roberta Castiglione, Thorsten Persigehl, Grit Herter-Sprie, Tim Hucho, Astrid Schauss, Björn Schumacher, Marcus Krüger
Publikováno v:
Cell Reports, Vol 25, Iss 4, Pp 1027-1039.e6 (2018)
Summary: Cdkn1a, which encodes p21, functions as a major route for p53-mediated cell-cycle arrest. However, the consequence of Cdkn1a gene dosage on tumor suppression has not been systematically investigated. Here, we employed BAC transgenesis to gen
Autor:
Mathieu J.M. Bertrand, Lucie Laurien, Snehlata Kumari, Teresa Corona, Masahiro Nagata, Robin Schwarzer, Vangelis Kondylis, Manolis Pasparakis, Janica L Wiederstein, Tom Delanghe, Hannah Schünke, Marcus Krüger
Publikováno v:
Nature Communications
NATURE COMMUNICATIONS
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
NATURE COMMUNICATIONS
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Receptor interacting protein kinase 1 (RIPK1) regulates cell death and inflammatory responses downstream of TNFR1 and other receptors, and has been implicated in the pathogenesis of inflammatory and degenerative diseases. RIPK1 kinase activity induce
Autor:
Alessandro, Torgovnick, Jan Michel, Heger, Vasiliki, Liaki, Jörg, Isensee, Anna, Schmitt, Gero, Knittel, Arina, Riabinska, Filippo, Beleggia, Lucie, Laurien, Uschi, Leeser, Christian, Jüngst, Florian, Siedek, Wenzel, Vogel, Niklas, Klümper, Hendrik, Nolte, Maike, Wittersheim, Lars, Tharun, Roberta, Castiglione, Marcus, Krüger, Astrid, Schauss, Sven, Perner, Manolis, Pasparakis, Reinhard, Büttner, Thorsten, Persigehl, Tim, Hucho, Grit Sophie, Herter-Sprie, Björn, Schumacher, Hans Christian, Reinhardt
Publikováno v:
Cell reports. 25(4)
Cdkn1a, which encodes p21, functions as a major route for p53-mediated cell-cycle arrest. However, the consequence of Cdkn1a gene dosage on tumor suppression has not been systematically investigated. Here, we employed BAC transgenesis to generate a C
Autor:
Isabel, Jaco, Alessandro, Annibaldi, Najoua, Lalaoui, Rebecca, Wilson, Tencho, Tenev, Lucie, Laurien, Chun, Kim, Kunzah, Jamal, Sidonie, Wicky John, Gianmaria, Liccardi, Diep, Chau, James M, Murphy, Gabriela, Brumatti, Rebecca, Feltham, Manolis, Pasparakis, John, Silke, Pascal, Meier
Publikováno v:
Molecular Cell
Summary TNF is an inflammatory cytokine that upon binding to its receptor, TNFR1, can drive cytokine production, cell survival, or cell death. TNFR1 stimulation causes activation of NF-κB, p38α, and its downstream effector kinase MK2, thereby promo