Sexually dimorphic effects of prenatal alcohol exposure on the murine skeleton

Autor: Lucie E. Bourne, Soher N. Jayash, Lysanne V. Michels, Mark Hopkinson, Fergus M. Guppy, Claire E. Clarkin, Paul Gard, Nigel Brissett, Katherine A. Staines

Publikováno v: Biology of Sex Differences, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract Background Prenatal alcohol exposure (PAE) can result in lifelong disabilities known as foetal alcohol spectrum disorder (FASD) and is associated with childhood growth deficiencies and increased bone fracture risk. However, the effects of PA

Externí odkaz: https://doaj.org/article/160685aea95f4b1e9f696616945c2466

Modulation of osteoblast differentiation and function by the P2X4 receptor

Autor: Isabel R. Orriss, Bethan K. Davies, Lucie E. Bourne, Timothy R. Arnett

Publikováno v: Purinergic Signalling.

Bone cells are known to express multiple P2 receptor subtypes, and the functional effects of receptor activation have been described for many of these. One exception is the P2X4 receptor, which despite strong expression in osteoblasts and osteoclasts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ddabb841ccf153b0688b09c0674c8e4
https://doi.org/10.1007/s11302-022-09887-x

2-Oxothiazolidine-4-carboxylic acid inhibits vascular calcification via induction of glutathione synthesis

Autor: Shori Thakur, Anwar R. Baydoun, Lucie E Bourne, Ken Farrington, Diana A. Gorog, Isabel R. Orriss, Jessal J Patel

open access article Arterial medial calcification (AMC), the deposition of hydroxyapatite in the medial layer of the arteries, is a known risk factor for cardiovascular events. Oxidative stress is a known inducer of AMC and endogenous antioxidants, s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc941c707f92750938965afebd0a551
https://dora.dmu.ac.uk/handle/2086/20389

Isolation and Generation of Osteoblasts

Autor: Inês P, Perpétuo, Lucie E, Bourne, Isabel R, Orriss

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1914

This chapter describes the isolation, culture, and staining of osteoblasts. The key advantages of this assay are that it allows direct measurement of bone matrix deposition and mineralization, as well as yielding good quantities of osteoblasts at def

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b7a22b0ebc13d4bd3344fb8ff2db3dc2
https://pubmed.ncbi.nlm.nih.gov/30729458

Inhibition of arterial medial calcification and bone mineralization by extracellular nucleotides: The same functional effect mediated by different cellular mechanisms

Autor: Dongxing Zhu, Britt Opdebeeck, Isabel R. Orriss, José Luis Millán, Caroline P.D. Wheeler-Jones, Vicky E MacRae, Patrick C. D'Haese, Lucie E Bourne, Timothy R. Arnett, Jessal J Patel

Publikováno v: Patel, J J, Zhu, D, Opdebeeck, B, D'Haese, P, Millán, J L, Bourne, L E, Wheeler-Jones, C P D, Arnett, T R, MacRae, V E & Orriss, I R 2018, ' Inhibition of arterial medial calcification and bone mineralization by extracellular nucleotides : The same functional effect mediated by different cellular mechanisms ', Journal of Cellular Physiology, vol. 233, no. 4, pp. 3230-3243 . https://doi.org/10.1002/jcp.26166
Journal of cellular physiology

Arterial medial calcification (AMC) is thought to share some outward similarities to skeletal mineralisation and has been associated with the transdifferentiation of vascular smooth muscle cells (VSMCs) to an osteoblast-like phenotype. ATP and UTP ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e465d519f358999e0f9481ac3cf88fe
https://pubmed.ncbi.nlm.nih.gov/28976001