Screening of a Library of Oligosaccharides Targeting Lectin LecB of Pseudomonas Aeruginosa and Synthesis of High Affinity Oligoglycoclusters

Autor: Lucie Dupin, Mathieu Noël, Silvère Bonnet, Albert Meyer, Thomas Géhin, Ludovic Bastide, Mialy Randriantsoa, Eliane Souteyrand, Claire Cottin, Gérard Vergoten, Jean-Jacques Vasseur, François Morvan, Yann Chevolot, Benoît Darblade

Publikováno v: Molecules, Vol 23, Iss 12, p 3073 (2018)

The Gram negative bacterium Pseudomonas aeruginosa (PA) is an opportunistic bacterium that causes severe and chronic infection of immune-depressed patients. It has the ability to form a biofilm that gives a selective advantage to the bacteria with re

Externí odkaz: https://doaj.org/article/b52e645cabb248778999716fa2cf23d4

Glycoclusters with Additional Functionalities for Binding to the LecA Lectin from Pseudomonas aeruginosa

Autor: Gérard Vergoten, Albert Meyer, Sébastien Vidal, François Morvan, Thomas Gehin, Mimouna Madaoui, Muchen Li, Jean-Jacques Vasseur, Shuai Wang, Lucie Dupin, Anthony Angeli, Yann Chevolot

Publikováno v: ChemistrySelect
ChemistrySelect, Wiley, 2017, 2 (32), pp.10420-10427. ⟨10.1002/slct.201702131⟩
ChemistrySelect, 2017, 2 (32), pp.10420-10427. ⟨10.1002/slct.201702131⟩

International audience; Due to the ability of Pseudomonas aeruginosa (PA) to develop antibiotic resistances, alternative therapeutic strategies have been proposed. Among others, carbohydrate multivalent molecules targeting lectin‐based virulent fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94de7f6d920eb16ead15d924b3636615
https://doi.org/10.1002/slct.201702131

Design and synthesis of galactosylated bifurcated ligands with nanomolar affinity for lectin lecA from pseudomonas aeruginosa

Autor: Lucie Dupin, Albert Meyer, Mimouna Madaoui, François Morvan, Gérard Vergoten, Mathieu Noël, Shuai Wang, Sébastien Vidal, Muchen Li, Yann Chevolot, Jean-Jacques Vasseur, Anthony Angeli, Thomas Gehin

Publikováno v: ChemBioChem
ChemBioChem, Wiley-VCH Verlag, 2017, 18 (11), pp.1036-1047. ⟨10.1002/cbic.201700154⟩
ChemBioChem, 2017, 18 (11), pp.1036-1047. ⟨10.1002/cbic.201700154⟩

International audience; Lectin A (LecA) from Pseudomonas aeruginosa is an established virulence factor. Glycoclusters that target LecA and are able to compete with human glycoconjugates present on epithelial cells are promising candidates to treat P.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b492dcb72ad259c51c25f3414e909f17
https://hal.archives-ouvertes.fr/hal-01533208

The influence of the aromatic aglycon of galactoclusters on the binding of LecA: a case study with O-phenyl, S-phenyl, O-benzyl, S-benzyl, O-biphenyl and O-naphthyl aglycons

Autor: Caroline Ligeour, Gérard Vergoten, Lucie Dupin, Olivier Vidal, Eliane Souteyrand, Thomas Gehin, François Morvan, F. Casoni, Albert Meyer, Jean-Jacques Vasseur, Yann Chevolot

Publikováno v: Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2014, 12 (45), pp.9166-9179. ⟨10.1039/c4ob01599a⟩
Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2014, 12 (45), pp.9166-9179. ⟨10.1039/c4ob01599a⟩

International audience; A library of 24 new mannose-centered tetragalactoclusters with four different linkers (di- and triethyleneglycol with phosphodiester or phosphorothioate linkages) and six different aromatic aglycons (O-phenyl, S-phenyl, O-benz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc1709193dfd1a9d85681cd4d1cfe0b
https://doi.org/10.1039/c4ob01599a

Importance of topology for glycocluster binding to Pseudomonas aeruginosa and Burkholderia ambifaria bacterial lectins

Autor: Lucie Dupin, Eliane Souteyrand, Albert Meyer, Sébastien Vidal, Anthony Angeli, Caroline Ligeour, Gérard Vergoten, Jean-Jacques Vasseur, Yann Chevolot, François Morvan

Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2015, 13, pp.11244-11254. ⟨10.1039/c5ob01445j⟩
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2015, 13, pp.11244-11254. ⟨10.1039/c5ob01445j⟩

International audience; Pseudomonas aeruginosa (PA) and Burkholderia ambifaria (BA) are two opportunistic Gram negative bacteria and major infectious agents involved in lung infection of cystic fibrosis patients. Both bacteria can develop resistance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207b35d0ed80daabcf203f7e2f1b551c
https://hal.archives-ouvertes.fr/hal-01318130