Výsledky vyhledávání - "Lucie Couture"

The ATP-Binding Cassette Transporters and Their Implication in Drug Disposition: A Special Look at the Heart

Autor: Jacques Turgeon, John A. Nash, Lucie Couture

Publikováno v: Pharmacological Reviews. 58:244-258

The passage of drugs across cell membranes dictates their absorption, distribution, metabolism, and excretion. This process is determined by several factors including the molecular weight of the compounds, their shape, degree of ionization, and bindi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d982f177f9c9ea8031cbc0767263216
https://doi.org/10.1124/pr.58.2.7

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Abstract B058: Development of AVID200, a novel and highly potent TGF-beta neutralizing immunotherapy

Autor: Jason Baardsnes, Maureen D. O'Connor-McCourt, John C. Zwaagstra, Christiane Cantin, Anne E.G. Lenferink, Traian Sulea, Renu Singh, Yves Durocher, James Koropatnick, Limei Tao, Catherine Collins, Lucie Couture

Publikováno v: Cancer Immunology Research. 4:B058-B058

Introduction: Elevated TGF-beta ligand markedly augments cancer progression primarily by suppressing the immune system in the tumor microenvironment, in particular by suppressing T-cell recruitment and/or activation. We developed AVID200, a novel dec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7dac55c61f555a5b89d2a5a7db1d93c6
https://doi.org/10.1158/2326-6066.imm2016-b058

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Abstract B024: Single-chain traps targeting transforming growth factor-beta (TGF-beta) home to tumors and reduce tumor growth and metastasis by counteracting TGF-beta-mediated immunosuppression

Autor: Christiane Cantin, Jason Baardsnes, Limei Tao, Yves Durocher, Traian Sulea, Anne E.G. Lenferink, Catherine Collins, Maureen D. O'Connor-McCourt, John C. Zwaagstra, Lucie Couture

Publikováno v: Cancer Immunology Research. 4:B024-B024

The TGF-beta superfamily includes a large number of ligands with physiological and pathological significance. In particular, elevated TGF-beta in the tumor microenvironment markedly augments cancer progression by inducing metastasis and angiogenesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86b024d930130c737b83cc9b7d31f2a2
https://doi.org/10.1158/2326-6074.cricimteatiaacr15-b024

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Temperature during cardiopulmonary bypass for coronary artery operations does not influence postoperative cognitive function: A prospective, randomized trial

Autor: Ross Robbins, Annie Sapin Leduc, Benoit DeVarennes, James F. Symes, Gilles Plourde, Jean E. Morin, Alain Ptito, Nadine Fosset, Lucie Couture, David A. Latter

Publikováno v: The Journal of Thoracic and Cardiovascular Surgery. 114(1):123-128

Objective: The objective was to examine the effect of temperature (28° vs 36° C) during cardiopulmonary bypass on postoperative cognitive functions in a prospective, double-blind, and randomized manner.Methods: Sixty-two patients scheduled for coro

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Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling: model structure and parameters determination

Autor: Lucie Couture, Veronique Michaud, Frédérique Fenneteau, Jacques Turgeon, Fahima Nekka, Jun Li

Publikováno v: Theoretical Biology and Medical Modelling, Vol 6, Iss 1, p 2 (2009)
Theoretical Biology & Medical Modelling

Background The expression and activity of P-glycoproteins due to genetic or environmental factors may have a significant impact on drug disposition, drug effectiveness or drug toxicity. Hence, characterization of drug disposition over a wide range of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8662077a9043fdfa0d6487189c555e0f
http://www.tbiomed.com/content/6/1/2

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Prediction of the disposition of a P-gp substrate in wild-type and knockout mice tissues: Development of a physiologically based pharmacokinetic (PBPK) model and its global sensitivity analysis

Autor: Frédérique Fenneteau, Fahima Nekka, Jacques Turgeon, Jun Li, Lucie Couture

Publikováno v: PAMM. 7:1121905-1121906

In order to improve understanding and prediction of drug disposition prior to in vivo experiments, we aimed to develop a PBPK model that accounts for the involvement of P-glycoprotein activity and expression in mouse brain, liver, kidney and heart ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41946fb754d6bb6e7e85d547733bda2e
https://doi.org/10.1002/pamm.200700608

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