Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Lucie Brulíková"'
Publikováno v:
ACS Omega, Vol 9, Iss 32, Pp 34808-34828 (2024)
Externí odkaz:
https://doaj.org/article/6cc7d4f7c0814da186471771f9e8114f
Publikováno v:
ACS Omega, Vol 4, Iss 21, Pp 19314-19323 (2019)
Externí odkaz:
https://doaj.org/article/b19ce4f660c44c41b85f0879627aca33
Autor:
Jan Chasák, Lucie Brulíková
Publikováno v:
Molecules, Vol 26, Iss 6, p 1603 (2021)
In this report, we employed the solid-phase synthetic approach to prepare variously substituted dihydropteridinones, tetrahydropyrrolopteridinones, and pyrimidodiazepinones, using a versatile building block-4,6-dichloro-5-nitropyrimidine. All these c
Externí odkaz:
https://doaj.org/article/a6dcc7816a794021883f38cc4ff36854
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 1949-1980 (2016)
The hetero-Diels–Alder reaction between a nitroso dienophile and a conjugated diene to give the 3,6-dihydro-2H-1,2-oxazine scaffold is useful for the synthesis of many biologically interesting molecules due to the diverse opportunities created by s
Externí odkaz:
https://doaj.org/article/659132afd5d84690b0013c022d101ea2
Publikováno v:
ACS Omega, Vol 5, Iss 16, Pp 9324-9333 (2020)
ACS Omega
ACS Omega
In this report, fluorescent systems consisting of two Rhodamine B moieties were designed and synthesized employing the solid-phase synthetic approach. The compounds were tested for their chemosensing behavior upon the addition of various metal ions o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a44235484e432768d52efa0e04fe42
https://doaj.org/article/9159e41a13ae43689792f511a58c1ffe
https://doaj.org/article/9159e41a13ae43689792f511a58c1ffe
Autor:
Milan Dak, Veronika Šlachtová, Marek Šebela, Václav Bazgier, Karel Berka, Natalia Smiejkowska, Lauren Oorts, Davie Cappoen, Lucie Brulíková
Publikováno v:
European journal of medicinal chemistry
Mycobacterial zinc metalloprotease-1 (Zmp1) is an essential enzyme for intracellular survival and pathogenicity of Mycobacterium tuberculosis. However, the exact mechanism of function of this enzyme remains unclear. This paper examines the effect of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5f7be30b205b68d20a51732368c315
https://doi.org/10.1016/j.ejmech.2022.114831
https://doi.org/10.1016/j.ejmech.2022.114831
Publikováno v:
Journal of Molecular Structure. 1183:182-189
The polymer-supported synthetic protocol for preparation of thiazolidinedione-pyrimidine hybrids was developed and applied for rapid and effective synthesis of a library of variously substituted conjugates. Reported synthetic methodology is based on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d4bb46e268aa222ff8896acc9073fd0
https://doi.org/10.1016/j.molstruc.2019.01.073
https://doi.org/10.1016/j.molstruc.2019.01.073
Publikováno v:
European journal of medicinal chemistry. 209
In this review, we summarize the published data on squaric acid analogues with a special focus on their use in medicinal chemistry and as potential drugs. Squaric acid is an interesting small molecule with an almost perfectly square shape, and its an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047255ccb8417f48eba3cef172528963
https://pubmed.ncbi.nlm.nih.gov/33035923
https://pubmed.ncbi.nlm.nih.gov/33035923
Publikováno v:
European journal of medicinal chemistry. 212
Causing approximately 10 million incident cases and 1.3–1.5 million deaths every year, Mycobacterium tuberculosis remains a global health problem. The risk is further exacerbated with latent tuberculosis (TB) infection, the HIV pandemic, and increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711230fda49b69509b1050d32efbfc40
https://pubmed.ncbi.nlm.nih.gov/33422979
https://pubmed.ncbi.nlm.nih.gov/33422979
Autor:
Václav Bazgier, Marek Šebela, Lucie Brulíková, Davie Cappoen, Eveline Torfs, Karel Berka, Veronika Šlachtová, Lauren Oorts
Publikováno v:
European journal of medicinal chemistry
Zinc metalloprotease 1 (Zmp1) is an extracellular enzyme, which has been found essential for the intracellular survival and pathogenesis of Mycobacterium tuberculosis. In this work, we designed and synthesized a series of novel thiazolidinedione-hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b7d97c48894c678d42bc10d7b46527
https://hdl.handle.net/10067/1657140151162165141
https://hdl.handle.net/10067/1657140151162165141