Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lucie, Oberhauser"'
Autor:
Lucie Oberhauser, Pierre Maechler
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 324 (2021)
Over the last decades, lipotoxicity and glucotoxicity emerged as established mechanisms participating in the pathophysiology of obesity-related type 2 diabetes in general, and in the loss of β-cell function in particular. However, these terms hold v
Externí odkaz:
https://doaj.org/article/f1ea190cbdd040f3b2df34c328ef5e6d
Autor:
Lucie Oberhauser, Cecilia Jiménez-Sánchez, Jesper Grud Skat Madsen, Dominique Duhamel, Susanne Mandrup, Thierry Brun, Pierre Maechler
Publikováno v:
Diabetologia, Vol. 65, No 4 (2022) pp. 705-720
Oberhauser, L, Jiménez-Sánchez, C, Madsen, J G S, Duhamel, D, Mandrup, S, Brun, T & Maechler, P 2022, ' Glucolipotoxicity promotes the capacity of the glycerolipid/NEFA cycle supporting the secretory response of pancreatic beta cells ', Diabetologia, vol. 65, no. 4, pp. 705-720 . https://doi.org/10.1007/s00125-021-05633-x
Oberhauser, L, Jiménez-Sánchez, C, Madsen, J G S, Duhamel, D, Mandrup, S, Brun, T & Maechler, P 2022, ' Glucolipotoxicity promotes the capacity of the glycerolipid/NEFA cycle supporting the secretory response of pancreatic beta cells ', Diabetologia, vol. 65, no. 4, pp. 705-720 . https://doi.org/10.1007/s00125-021-05633-x
Aims/hypothesis: Chronic exposure of pancreatic beta cells to high glucose and fatty acids has been proposed to induce glucolipotoxicity. However, contradictory results suggest adaptations of the beta cells, which might be instrumental for partial pr
Autor:
Arthur Radoux-Mergault, Lucie Oberhauser, Simone Aureli, Francesco Luigi Gervasio, Miriam Stoeber
G protein-coupled receptors in intracellular organelles can be activated in response to membrane permeant ligands, which contributes to the diversity and specificity of agonist action. The opioid receptors (ORs) provide a striking example, where opio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4336de54f9aecbf7b2de465fc5be4f9d
https://doi.org/10.1101/2022.12.12.520050
https://doi.org/10.1101/2022.12.12.520050
Autor:
Thierry Brun, Cecilia Jiménez-Sánchez, Jesper Grud Skat Madsen, Noushin Hadadi, Dominique Duhamel, Clarissa Bartley, Lucie Oberhauser, Mirko Trajkovski, Susanne Mandrup, Pierre Maechler
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 3982 (2020)
Chronic exposure of pancreatic β-cells to elevated nutrient levels impairs their function and potentially induces apoptosis. Like in other cell types, AMPK is activated in β-cells under conditions of nutrient deprivation, while little is known on A
Externí odkaz:
https://doaj.org/article/9493167bf8f04c5db20c0fd4b34b87be
Autor:
Brenda R. Kwak, Filippo Molica, Thierry Brun, Mariagrazia Grimaldi, Clarissa Bartley, Domenico Bosco, Lucie Oberhauser, Pierre Maechler, Marc Chanson
Publikováno v:
American Journal of Physiology. Endocrinology and Metabolism, Vol. 317, No 1 (2019) pp. E25-E41
Fructose is widely used as a sweetener in processed food and is also associated with metabolic disorders, such as obesity. However, the underlying cellular mechanisms remain unclear, in particular, regarding the pancreatic β-cell. Here, we investiga
Autor:
Lucie, Oberhauser, Miriam, Stoeber
Publikováno v:
Handbook of experimental pharmacology. 271
The kappa opioid receptor (KOR) has emerged as a promising therapeutic target for pain and itch treatment. There is growing interest in biased agonists that preferentially activate select signaling pathways downstream of KOR activation on the cellula
Publikováno v:
Handbook of Experimental Pharmacology
The Kappa Opioid Receptor ISBN: 9783030890735
The Kappa Opioid Receptor ISBN: 9783030890735
The kappa opioid receptor (KOR) has emerged as a promising therapeutic target for pain and itch treatment. There is growing interest in biased agonists that preferentially activate select signaling pathways downstream of KOR activation on the cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070d2c974ee759510ab2626c0c957bea
https://archive-ouverte.unige.ch/unige:148101
https://archive-ouverte.unige.ch/unige:148101
Autor:
Vanessa Lavallard, Antoine Goujon, Thierry Brun, Sabrina Granziera, Aurélien Roux, Adai Colom, Lucie Oberhauser, Stefan Matile, Pierre Maechler
Publikováno v:
Biochimica et Biophysica Acta-Molecular Cell Research, Vol. 1867, No 2 (2020) P. 118619
Chronic exposure to elevated levels of glucose and free fatty acids impairs beta-cell function, leading to insulin secretion defects and eventually beta-cell failure. Using a semi-high throughput approach applied to INS-1E beta-cells, we tested multi