Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Lucie, Karayan"'
Autor:
Cathy Pichol-Thievend, Oceane Anezo, Aafrin M. Pettiwala, Guillaume Bourmeau, Remi Montagne, Anne-Marie Lyne, Pierre-Olivier Guichet, Pauline Deshors, Alberto Ballestín, Benjamin Blanchard, Juliette Reveilles, Vidhya M. Ravi, Kevin Joseph, Dieter H. Heiland, Boris Julien, Sophie Leboucher, Laetitia Besse, Patricia Legoix, Florent Dingli, Stephane Liva, Damarys Loew, Elisa Giani, Valentino Ribecco, Charita Furumaya, Laura Marcos-Kovandzic, Konstantin Masliantsev, Thomas Daubon, Lin Wang, Aaron A. Diaz, Oliver Schnell, Jürgen Beck, Nicolas Servant, Lucie Karayan-Tapon, Florence M. G. Cavalli, Giorgio Seano
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-27 (2024)
Abstract Glioblastoma (GBM) is a highly lethal type of cancer. GBM recurrence following chemoradiation is typically attributed to the regrowth of invasive and resistant cells. Therefore, there is a pressing need to gain a deeper understanding of the
Externí odkaz:
https://doaj.org/article/3b619e0cc25442dda280674d2cd28cb1
Autor:
Aurélie Joussaume, Chryso Kanthou, Olivier E. Pardo, Lucie Karayan-Tapon, Omar Benzakour, Fatima Dkhissi
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 4, Pp 3278-3293 (2024)
Protein S (PROS1) is a vitamin K-dependent anticoagulant factor, which also acts as an agonist for the TYRO3, AXL, and MERTK (TAM) tyrosine kinase receptors. PROS1 is produced by the endothelium which also expresses TAM receptors, but little is known
Externí odkaz:
https://doaj.org/article/7eb8813ce6a24d078a0b98f358bbfe47
Autor:
Amandine Desette, Pierre-Olivier Guichet, Sheik Emambux, Konstantin Masliantsev, Ulrich Cortes, Birama Ndiaye, Serge Milin, Simon George, Mathieu Faigner, Julie Tisserand, Afsaneh Gaillard, Sébastien Brot, Michel Wager, David Tougeron, Lucie Karayan-Tapon
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 5, Pp 757-782 (2023)
Background & Aims: Brain metastases (BMs) from colorectal cancer (CRC) are associated with significant morbidity and mortality, with chemoresistance and short overall survival. Migrating cancer stem cells with the ability to initiate BM have been des
Externí odkaz:
https://doaj.org/article/f4d7a3a6534f4480b9f86856d74f1e35
Autor:
Elisa Le Boiteux, Franck Court, Pierre‐Olivier Guichet, Catherine Vaurs‐Barrière, Isabelle Vaillant, Emmanuel Chautard, Pierre Verrelle, Bruno M. Costa, Lucie Karayan‐Tapon, Anne Fogli, Philippe Arnaud
Publikováno v:
Molecular Oncology, Vol 15, Iss 8, Pp 1995-2010 (2021)
In human, the 39 coding HOX genes and 18 referenced noncoding antisense transcripts are arranged in four genomic clusters named HOXA, B, C, and D. This highly conserved family belongs to the homeobox class of genes that encode transcription factors r
Externí odkaz:
https://doaj.org/article/fed95548f2564556b60979aca372b0ee
Publikováno v:
Cancer Medicine, Vol 9, Iss 17, Pp 6344-6353 (2020)
Abstract Background Epigenetic inactivation of O6‐methylguanine‐methyltransferase (MGMT) gene by methylation of its promoter is predictive of Temozolomid (TMZ) response in glioblastoma (GBM). MGMT is located on chromosome 10q26 and the loss of ch
Externí odkaz:
https://doaj.org/article/379d796c9efa44ef9e38e62e58184717
Autor:
Gaelle Tachon, Arnaud Chong-Si-Tsaon, Thierry Lecomte, Audelaure Junca, Éric Frouin, Elodie Miquelestorena-Standley, Julie Godet, Camille Evrard, Violaine Randrian, Romain Chautard, Marie-Luce Auriault, Valérie Moulin, Serge Guyetant, Gaelle Fromont, Lucie Karayan-Tapon, David Tougeron
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
Determination of microsatellite instability (MSI) using molecular test and deficient mismatch repair (dMMR) using immunohistochemistry (IHC) has major implications on colorectal cancer (CRC) management. The HSP110 T17 microsatellite has been reported
Externí odkaz:
https://doaj.org/article/ee7c9693b6df4e839393f10ca1698223
Autor:
Gaëlle Tachon, Ulrich Cortes, Sophie Richard, Sébastien Martin, Serge Milin, Camille Evrard, Corinne Lamour, Lucie Karayan‐Tapon
Publikováno v:
Cancer Medicine, Vol 8, Iss 18, Pp 7556-7566 (2019)
Abstract Introduction ALK and ROS1 rearrangements are molecular targets of several tyrosine kinase inhibitors. RNA‐sequencing approaches are regarded as the new standard for fusion gene detection, representing an alternative to standard immunohisto
Externí odkaz:
https://doaj.org/article/cd5db8b4c49e4ba0a0b2cd5c7144f997
Autor:
Violaine Randrian, Amandine Desette, Sheik Emambux, Valentin Derangere, Pauline Roussille, Eric Frouin, Julie Godet, Lucie Karayan-Tapon, François Ghiringhelli, David Tougeron
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Incidence of brain metastases has increased in patients with colorectal cancer (CRC) as their survival has improved. CD3 T-cells and, lately, DGMate (DiGital tuMor pArameTErs) score, have been identified as prognostic factors in locally advanced CRC.
Externí odkaz:
https://doaj.org/article/e7310c5e2ab348bfbedccdf3f9f9c303
Autor:
Camille Evrard, Stéphane Messina, David Sefrioui, Éric Frouin, Marie-Luce Auriault, Romain Chautard, Aziz Zaanan, Marion Jaffrelot, Christelle De La Fouchardière, Thomas Aparicio, Romain Coriat, Julie Godet, Christine Silvain, Violaine Randrian, Jean-Christophe Sabourin, Rosine Guimbaud, Elodie Miquelestorena-Standley, Thierry Lecomte, Valérie Moulin, Lucie Karayan-Tapon, Gaëlle Tachon, David Tougeron
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 8, p 4427 (2022)
Deficient mismatch repair system (dMMR)/microsatellite instability (MSI) is found in about 5% of metastatic colorectal cancers (mCRCs) with a major therapeutic impact for immune checkpoint inhibitor (ICI) use. We conducted a multicentre study includi
Externí odkaz:
https://doaj.org/article/0026cfb6268f42bcba3d36cf3204f151
Autor:
Elisa Le Boiteux, Pierre-Olivier Guichet, Konstantin Masliantsev, Bertille Montibus, Catherine Vaurs-Barriere, Céline Gonthier-Gueret, Emmanuel Chautard, Pierre Verrelle, Lucie Karayan-Tapon, Anne Fogli, Franck Court, Philippe Arnaud
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4743 (2022)
Glioblastomas represent approximatively half of all gliomas and are the most deadly and aggressive form. Their therapeutic resistance and tumor relapse rely on a subpopulation of cells that are called Glioma Stem Cells (GSCs). Here, we investigated t
Externí odkaz:
https://doaj.org/article/eaa16bcefe1a4cf78d9d79e9ad983d0e