Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Lucie, Delemotte"'
Autor:
Johanna KS Tiemann, Magdalena Szczuka, Lisa Bouarroudj, Mohamed Oussaren, Steven Garcia, Rebecca J Howard, Lucie Delemotte, Erik Lindahl, Marc Baaden, Kresten Lindorff-Larsen, Matthieu Chavent, Pierre Poulain
Publikováno v:
eLife, Vol 12 (2024)
The rise of open science and the absence of a global dedicated data repository for molecular dynamics (MD) simulations has led to the accumulation of MD files in generalist data repositories, constituting the dark matter of MD — data that is techni
Externí odkaz:
https://doaj.org/article/c3061f03d4e2413684cd2f2b1b6d8754
Autor:
Darko Mitrovic, Sarah E McComas, Claudia Alleva, Marta Bonaccorsi, David Drew, Lucie Delemotte
Publikováno v:
eLife, Vol 12 (2023)
Sugar porters (SPs) represent the largest group of secondary-active transporters. Some members, such as the glucose transporters (GLUTs), are well known for their role in maintaining blood glucose homeostasis in mammals, with their expression upregul
Externí odkaz:
https://doaj.org/article/7c2c94be14214a15ba67eb14274de96a
Autor:
Sarah E McComas, Tom Reichenbach, Darko Mitrovic, Claudia Alleva, Marta Bonaccorsi, Lucie Delemotte, David Drew
Publikováno v:
eLife, Vol 12 (2023)
In mammals, glucose transporters (GLUT) control organism-wide blood-glucose homeostasis. In human, this is accomplished by 14 different GLUT isoforms, that transport glucose and other monosaccharides with varying substrate preferences and kinetics. N
Externí odkaz:
https://doaj.org/article/5930635316fc49f8a92f558bb78c0106
Autor:
Ahmad Elbahnsi, John Cowgill, Verena Burtscher, Linda Wedemann, Luise Zeckey, Baron Chanda, Lucie Delemotte
Publikováno v:
eLife, Vol 12 (2023)
Hyperpolarized-activated and cyclic nucleotide-gated (HCN) channels are the only members of the voltage-gated ion channel superfamily in mammals that open upon hyperpolarization, conferring them pacemaker properties that are instrumental for rhythmic
Externí odkaz:
https://doaj.org/article/a778ab82133345d6a0097b0f26ea1a96
Autor:
Gamma Chi, Qiansheng Liang, Akshay Sridhar, John B. Cowgill, Kasim Sader, Mazdak Radjainia, Pu Qian, Pablo Castro-Hartmann, Shayla Venkaya, Nanki Kaur Singh, Gavin McKinley, Alejandra Fernandez-Cid, Shubhashish M. M. Mukhopadhyay, Nicola A. Burgess-Brown, Lucie Delemotte, Manuel Covarrubias, Katharina L. Dürr
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, Chi et al. report cryo-EM structures of the human Kv3.1a channel, revealing a unique arrangement of the cytoplasmic T1 domain, which allows the interactions with the C-terminal axonal targeting motif and key components of the gating machinery.
Externí odkaz:
https://doaj.org/article/3b1f137234894981ba29f62e3c7d792a
Autor:
Annie M Westerlund, Akshay Sridhar, Leo Dahl, Alma Andersson, Anna-Yaroslava Bodnar, Lucie Delemotte
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 10, p e1010583 (2022)
Calmodulin (CaM) is a calcium sensor which binds and regulates a wide range of target-proteins. This implicitly enables the concentration of calcium to influence many downstream physiological responses, including muscle contraction, learning and depr
Externí odkaz:
https://doaj.org/article/de1f3494b1c14b96a419a69eeb53a105
Publikováno v:
eLife, Vol 11 (2022)
The KV7.4 and KV7.5 subtypes of voltage-gated potassium channels play a role in important physiological processes such as sound amplification in the cochlea and adjusting vascular smooth muscle tone. Therefore, the mechanisms that regulate KV7.4 and
Externí odkaz:
https://doaj.org/article/4a1c3bae62fd41169e4fabd9e94adbda
Publikováno v:
eLife, Vol 11 (2022)
The plasma membrane of a biological cell is a complex assembly of lipids and membrane proteins, which tightly regulate transmembrane transport. When a cell is exposed to strong electric field, the membrane integrity becomes transiently disrupted by f
Externí odkaz:
https://doaj.org/article/1c6f6542559348d0b373e294bd31f3e4
Publikováno v:
eLife, Vol 10 (2021)
Ligand binding stabilizes different G protein-coupled receptor states via a complex allosteric process that is not completely understood. Here, we have derived free energy landscapes describing activation of the β2 adrenergic receptor bound to ligan
Externí odkaz:
https://doaj.org/article/7376f2d61a57476ba3098836f6f979af
Autor:
Marina A Kasimova, Debanjan Tewari, John B Cowgill, Willy Carrasquel Ursuleaz, Jenna L Lin, Lucie Delemotte, Baron Chanda
Publikováno v:
eLife, Vol 8 (2019)
In contrast to most voltage-gated ion channels, hyperpolarization- and cAMP gated (HCN) ion channels open on hyperpolarization. Structure-function studies show that the voltage-sensor of HCN channels are unique but the mechanisms that determine gatin
Externí odkaz:
https://doaj.org/article/ec37f2fe477a4a0880de9334fca6afd9