Zobrazeno 1 - 10
of 688
pro vyhledávání: '"Lucie, Carrier"'
Autor:
Moritz Meyer-Jens, Kristin Wenzel, Karina Grube, Julia Rüdebusch, Elisabeth Krämer, Martin Bahls, Kilian Müller, Hannah Voß, Hartmut Schlüter, Stephan B. Felix, Lucie Carrier, Stephanie Könemann, Saskia Schlossarek
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 7, Iss , Pp 100059- (2024)
Sacubitril/valsartan (Sac/Val) belongs to the group of angiotensin receptor–neprilysin inhibitors and has been used for the treatment of heart failure (HF) for several years. The mechanisms that mediate the beneficial effects of Sac/Val are not yet
Externí odkaz:
https://doaj.org/article/d2ef4d241de746f5a3ef0a5e68bc9de6
Autor:
Oumaima Laghzali, MSc, Shahriar Shalikar, MSc, Siqin Liu, MSc, Joao dos Santos Periquito, PhD, Andreas Pohlmann, PhD, Frank Kober, PhD, Lucie Carrier, PhD, Thoralf Niendorf, Sonia Waiczies, PhD, Min-Chi Ku, PhD
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 26, Iss , Pp 100969- (2024)
Externí odkaz:
https://doaj.org/article/21d2b1937c2b4ecd8688bd52e88c2c2e
Autor:
Edgar E. Nollet, Sila Algül, Max Goebel, Saskia Schlossarek, Nicole N. van der Wel, Judith J.M. Jans, Mark A. van de Wiel, Jaco C. Knol, Thang V. Pham, Sander R. Piersma, Richard de Goeij-de Haas, Jill Hermans, Jan Bert van Klinken, Michel van Weeghel, Riekelt H. Houtkooper, Lucie Carrier, Connie R. Jimenez, Diederik W.D. Kuster, Jolanda van der Velden
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 6, Iss , Pp 100050- (2023)
Background and aim: Phenotypic expression of hypertrophic cardiomyopathy (HCM) and disease course are associated with unfavorable metabolic health. We investigated if Western diet (WD) feeding is sufficient to trigger cardiac hypertrophy and dysfunct
Externí odkaz:
https://doaj.org/article/a35423357cb242d7a31ba3d7bed60292
Autor:
Niels Pietsch, Jiancheng Cheng, Antonietta Fazio, Leonie Ewald, Erda Alizoti, Elisabeth Krämer, Ellen Orthey, Lucie Carrier, Sonia R Singh
Publikováno v:
Stem Cell Research, Vol 71, Iss , Pp 103188- (2023)
Variants in CRYAB can lead to desmin-related (cardio-)myopathy (DRM), a genetic muscle disorder with no curative treatment available. We introduced a homozygous CRYAB c.358G > A (p.Arg120Gly) mutation, which is established for the study of DRM in mic
Externí odkaz:
https://doaj.org/article/690b5a4cbefd4b42b1db8d1852a43c94
Disease modeling of a mutation in α‐actinin 2 guides clinical therapy in hypertrophic cardiomyopathy
Autor:
Maksymilian Prondzynski, Marc D Lemoine, Antonia TL Zech, András Horváth, Vittoria Di Mauro, Jussi T Koivumäki, Nico Kresin, Josefine Busch, Tobias Krause, Elisabeth Krämer, Saskia Schlossarek, Michael Spohn, Felix W Friedrich, Julia Münch, Sandra D Laufer, Charles Redwood, Alexander E Volk, Arne Hansen, Giulia Mearini, Daniele Catalucci, Christian Meyer, Torsten Christ, Monica Patten, Thomas Eschenhagen, Lucie Carrier
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 8, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/20088ae3e8874325a43b88d720c8d7fd
Autor:
Min-Chi Ku, Frank Kober, Yi-Ching Lai, Andreas Pohlmann, Fatimunnisa Qadri, Michael Bader, Lucie Carrier, Thoralf Niendorf
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 23, Iss 1, Pp 1-13 (2021)
Abstract Background Hypertrophic cardiomyopathy (HCM) related myocardial vascular remodelling may lead to the reduction of myocardial blood supply and a subsequent progressive loss of cardiac function. This process has been difficult to observe and t
Externí odkaz:
https://doaj.org/article/e03c11be46e0404b8684de5964ee7cdb
Autor:
Nele Warnecke, Bärbel M. Ulmer, Sandra D. Laufer, Aya Shibamiya, Elisabeth Krämer, Christiane Neuber, Sophia Hanke, Charlotta Behrens, Malte Loos, Julia Münch, Jirko Kühnisch, Sabine Klaassen, Thomas Eschenhagen, Monica Patten-Hamel, Lucie Carrier, Giulia Mearini
Publikováno v:
Stem Cell Research, Vol 55, Iss , Pp 102489- (2021)
MYBPC3 is the most frequently affected gene in hypertrophic cardiomyopathy (HCM), which is an autosomal-dominant cardiac disease caused by mutations in sarcomeric proteins. Bi-allelic truncating MYBPC3 mutations are associated with severe forms of ne
Externí odkaz:
https://doaj.org/article/823c7120cb5b4e818f122df69c905bed
Disease modeling of a mutation in α‐actinin 2 guides clinical therapy in hypertrophic cardiomyopathy
Autor:
Maksymilian Prondzynski, Marc D Lemoine, Antonia TL Zech, András Horváth, Vittoria Di Mauro, Jussi T Koivumäki, Nico Kresin, Josefine Busch, Tobias Krause, Elisabeth Krämer, Saskia Schlossarek, Michael Spohn, Felix W Friedrich, Julia Münch, Sandra D Laufer, Charles Redwood, Alexander E Volk, Arne Hansen, Giulia Mearini, Daniele Catalucci, Christian Meyer, Torsten Christ, Monica Patten, Thomas Eschenhagen, Lucie Carrier
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 12, Pp 1-18 (2019)
Abstract Hypertrophic cardiomyopathy (HCM) is a cardiac genetic disease accompanied by structural and contractile alterations. We identified a rare c.740C>T (p.T247M) mutation in ACTN2, encoding α‐actinin 2 in a HCM patient, who presented with lef
Externí odkaz:
https://doaj.org/article/3dc134090e7a4e27beee5c5b257be092
Autor:
Antonia T. L. Zech, Maksymilian Prondzynski, Sonia R. Singh, Niels Pietsch, Ellen Orthey, Erda Alizoti, Josefine Busch, Alexandra Madsen, Charlotta S. Behrens, Moritz Meyer-Jens, Giulia Mearini, Marc D. Lemoine, Elisabeth Krämer, Diogo Mosqueira, Sanamjeet Virdi, Daniela Indenbirken, Maren Depke, Manuela Gesell Salazar, Uwe Völker, Ingke Braren, William T. Pu, Thomas Eschenhagen, Elke Hammer, Saskia Schlossarek, Lucie Carrier
Publikováno v:
Cells, Vol 11, Iss 17, p 2745 (2022)
Genetic variants in α-actinin-2 (ACTN2) are associated with several forms of (cardio)myopathy. We previously reported a heterozygous missense (c.740C>T) ACTN2 gene variant, associated with hypertrophic cardiomyopathy, and characterized by an electro
Externí odkaz:
https://doaj.org/article/109fa3ab16674cf981367758f4aa3eb1
Autor:
Kristin Wenzel, Elisabeth Krämer, Birgit Geertz, Lucie Carrier, Stephan B. Felix, Stephanie Könemann, Saskia Schlossarek
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
The ubiquitin-proteasome system (UPS) and the autophagy-lysosomal pathway (ALP) are the main proteolytic systems involved in cellular homeostasis. Since cardiomyocytes, as terminally differentiated cells, lack the ability to share damaged proteins wi
Externí odkaz:
https://doaj.org/article/2cd2198e0a0f4f1688a627357ad2f042