Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Luciano R. Vilela"'
Autor:
Isabel Vieira de Assis Lima, Hyorrana Priscila Pereira Pinto, Paula Maria Quaglio Bellozi, Maria Carolina Machado da Silva, Luciano R. Vilela, Fabrício A. Moreira, Márcio Flávio Dutra Moraes, Antônio Carlos Pinheiro de Oliveira
Publikováno v:
Pharmacological Reports. 74:1099-1106
The phytocannabinoid cannabidiol (CBD) has previously shown to have anticonvulsant effects in preclinical and clinical studies. Recently, CBD has been approved to treat certain types of drug-resistant epileptic syndromes. However, the underlying mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9692c126dab4b1e23418151b36d4ba70
https://doi.org/10.1007/s43440-022-00391-y
https://doi.org/10.1007/s43440-022-00391-y
Autor:
Isabel Vieira de Assis Lima, Edleusa M. L. Batista, Fabrício A. Moreira, Ivan Lucas Brandão, Luciano R. Vilela, Paula Maria Quaglio Bellozi, Antônio Carlos Pinheiro de Oliveira, Márcio Flávio Dutra Moraes, Fabiola M. Ribeiro
Publikováno v:
Neuropharmacology. 176
The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/Akt)/mechanistic target of rapamycin (mTOR) signaling pathway has been associated with several pathologies in the central nervous system (CNS), including epilepsy. There is evidence suppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::452ffe566dae655d5f487e054c49410f
https://pubmed.ncbi.nlm.nih.gov/32574650
https://pubmed.ncbi.nlm.nih.gov/32574650
Autor:
Érica B. Kunsch, Márcio Flávio Dutra Moraes, Aline Silva de Miranda, Antônio Lúcio Teixeira, Hyorrana Priscila Pereira Pinto, Antônio Carlos Pinheiro de Oliveira, Fabrício A. Moreira, Érica Leandro Marciano Vieira, Luciano R. Vilela, Isabel Vieira de Assis Lima
Publikováno v:
Epilepsybehavior : EB. 75
Cannabidiol (CBD), the main nonpsychotomimetic compound from Cannabis sativa, inhibits experimental seizures in animal models and alleviates certain types of intractable epilepsies in patients. Its pharmacological profile, however, is still uncertain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49bec6287fccda61934fdea89043b5f
https://pubmed.ncbi.nlm.nih.gov/28821005
https://pubmed.ncbi.nlm.nih.gov/28821005
It has been suggested for centuries that Cannabis sativa may be effective in treating epilepsy. The scientific evidence, however, has remained surprisingly scant. Δ9-Tetrahydrocannabinol, the main active compound from this plant, and other phytocann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a33726412465de6dd1d765984d3d501d
https://doi.org/10.1016/b978-0-12-800756-3.00073-9
https://doi.org/10.1016/b978-0-12-800756-3.00073-9
Autor:
Ana Flávia Almeida, Pedro H. Gobira, Luciano R. Vilela, Thércia G. Viana, Fabrício A. Moreira
Publikováno v:
Brasília Médica. 48:277-283
Method. The text is based on the main articles on the discovery of the mechanisms through which cannabis exerts its effects, as well as on contemporary research trying to develop new medicines based on the endocannabinoid system. Results. Despite the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebe59f00bb0b609b0360858ffd1b1bf0
https://doi.org/10.14242/2236-5117.2013v48n3a206p277
https://doi.org/10.14242/2236-5117.2013v48n3a206p277
Autor:
Ariane Barros Diniz, Bruna Araújo David, Gustavo B. Menezes, Fabrício A. Moreira, Maísa Mota Antunes, Lindisley Ferreira Gomides, Luciano R. Vilela
Publikováno v:
Mediators of Inflammation
Mediators of Inflammation, Vol 2015 (2015)
Mediators of Inflammation, Vol 2015 (2015)
Cocaine is a commonly abused illicit drug that causes significant morbidity and mortality. The most severe and common complications are seizures, ischemic strokes, myocardial infarction, and acute liver injury. Here, we demonstrated that acute cocain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bfd6d0e2b298161ba81ff1efaaac0da
Autor:
Pedro H. Gobira, Luciano R. Vilela, Fabrício A. Moreira, Antonio C. de Oliveira, José Alexandre de Souza Crippa, Rebeca P. M. Santos, Luciene B. Vieira, Bruno D. C. Goncalves, Daniele C. Aguiar
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Cannabidiol (CBD), a major non-psychotomimetic constituent of Cannabis sativa, has therapeutic potential for certain psychiatric and neurological disorders. Studies in laboratory animals and limited human trials indicate that CBD has anticonvulsant a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c46c30aa77efa970f5b94c234c49aef
Autor:
Márcio Flávio Dutra Moraes, Antônio Carlos Pinheiro de Oliveira, Daniel de Castro Medeiros, Fabrício A. Moreira, Luciano R. Vilela
Publikováno v:
Basicclinical pharmacologytoxicology. 115(4)
Selective blockade of anandamide hydrolysis, through the inhibition of the FAAH enzyme, has anticonvulsant effects, which are mediated by CB1 receptors. Anandamide, however, also activates TRPV1 channels, generally with an opposite outcome on neurona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9cf30f0b48218cfb4986b408e941d06
https://pubmed.ncbi.nlm.nih.gov/24674273
https://pubmed.ncbi.nlm.nih.gov/24674273
Autor:
Márcio Flávio Dutra Moraes, Luciano R. Vilela, Antônio Carlos Pinheiro de Oliveira, Gustavo Henrique de Souza e Rezende, Daniel de Castro Medeiros, Fabrício A. Moreira
Publikováno v:
Epilepsy research. 104(3)
Summary Cannabinoids and drugs that increase endocannabinoid levels inhibit neuronal excitability and restrain epileptic seizures through CB1 receptor activation. Nevertheless, the results have not been entirely consistent, since pro-convulsant effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e742bcb816a112332850aa5425d44fe6
https://pubmed.ncbi.nlm.nih.gov/23352737
https://pubmed.ncbi.nlm.nih.gov/23352737