Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Luciano H. Apponi"'
Autor:
Prashant Monian, Chikdu Shivalila, Genliang Lu, Mamoru Shimizu, David Boulay, Karley Bussow, Michael Byrne, Adam Bezigian, Arindom Chatterjee, David Chew, Jigar Desai, Frank Favaloro, Jack Godfrey, Andrew Hoss, Naoki Iwamoto, Tomomi Kawamoto, Jayakanthan Kumarasamy, Anthony Lamattina, Amber Lindsey, Fangjun Liu, Richard Looby, Subramanian Marappan, Jake Metterville, Ronelle Murphy, Jeff Rossi, Tom Pu, Bijay Bhattarai, Stephany Standley, Snehlata Tripathi, Hailin Yang, Yuan Yin, Hui Yu, Cong Zhou, Luciano H. Apponi, Pachamuthu Kandasamy, Chandra Vargeese
Publikováno v:
Nature Biotechnology. 40:1093-1102
Technologies that recruit and direct the activity of endogenous RNA-editing enzymes to specific cellular RNAs have therapeutic potential, but translating them from cell culture into animal models has been challenging. Here we describe short, chemical
Autor:
Juili Dilip Shelke, Michael Byrne, Hailin Yang, Pachamuthu Kandasamy, Keith Bowman, Lauren Norwood, Luciano H. Apponi, Kenneth Longo, Yuan Yin, Lankai Guo, Anee Shah, Chandra Vargeese, Vinod Vathipadiekal, Naoki Iwamoto, Chikdu Shakti Shivalila, Fangjun Liu, Richard Looby
Publikováno v:
Translational Vision Science & Technology. 10:23
Purpose Antisense oligonucleotides have been under investigation as potential therapeutics for many diseases, including inherited retinal diseases. Chemical modifications, such as chiral phosphorothioate (PS) backbone modification, are often used to
Autor:
Bo Ying, Bob D. Brown, Wendy Cyr, Nazef Naim, Chaitali Dutta, Marc Abrams, Rohan Diwanji, Dongyu Chen, Chengjung Lai, Benjamin Holmes, Natalie Pursell, Marita Larsson Cohen, Utsav Saxena, Henryk T. Dudek, Eduardo Salido, Luciano H. Apponi, Anee Shah, Weimin Wang, Wei Zhou, Nicole Avitahl-Curtis, Xue Shui, Martin Koser
Publikováno v:
Molecular Therapy. 24(4):770-778
Primary hyperoxaluria type 1 (PH1) is an autosomal recessive, metabolic disorder caused by mutations of alanine-glyoxylate aminotransferase (AGT), a key hepatic enzyme in the detoxification of glyoxylate arising from multiple normal metabolic pathway
Autor:
Yanru Wang, Christophe Pichavant, James M. Ervasti, Adriana Simionescu-Bankston, Grace K. Pavlath, Luciano H. Apponi, John T. Olthoff, James P. Canner, Joseph J. Belanto, Craig M Steeds
Publikováno v:
American Journal of Physiology-Cell Physiology. 308:C919-C931
Myoblast fusion is critical for proper muscle growth and regeneration. During myoblast fusion, the localization of some molecules is spatially restricted; however, the exact reason for such localization is unknown. Creatine kinase B (CKB), which repl
Publikováno v:
Journal of Neuromuscular Diseases
Background Oculopharyngeal muscular dystrophy (OPMD), a late onset disorder affecting specific skeletal muscles, is caused by a (GCG)n expansion mutation in the gene encoding the mRNA processing protein, polyadenylate binding protein nuclear 1 (PABPN
Autor:
Luciano H. Apponi, Bin Tian, Anita H. Corbett, Weiting Xu, Katherine E. Vest, Dinghai Zheng, Ayan Banerjee, Eric B. Dammer, Grace K. Pavlath, Brittany L. Phillips, Julia Yu
Publikováno v:
Human molecular genetics. 26(17)
Oculopharyngeal muscular dystrophy (OPMD) is a late onset disease caused by polyalanine expansion in the poly(A) binding protein nuclear 1 (PABPN1). Several mouse models have been generated to study OPMD; however, most of these models have employed t
Autor:
Luciano H. Apponi, Ivan Zlatev, Dinah W.Y. Sah, Stephany Michelle Standley, Nenad Svrzikapa, Gregory L. Verdine, Chandra Vargeese, David Butler, Meena, Genliang Lu, Jason Jingxin Zhang, Naoki Iwamoto, Susovan Mohapatra, Maria Frank-Kamenetsky
Publikováno v:
Nature biotechnology. 35(9)
Whereas stereochemical purity in drugs has become the standard for small molecules, stereoisomeric mixtures containing as many as a half million components persist in antisense oligonucleotide (ASO) therapeutics because it has been feasible neither t
Autor:
Juliana Rico Pires, Lícia Bezerra Cavalcante, Raquel M. Scarel-Caminaga, Elisa Maria Aparecida Giro, Luciano H. Apponi, Denise Madalena Palomari Spolidorio, Marisa Veiga Capela, Sandro Roberto Valentini, Carlos Rossa, Marcia Hiromi Tanaka
Publikováno v:
Journal of Periodontology. 83:926-935
Individuals with Down syndrome (DS) have a higher prevalence and severity of periodontal disease, which cannot be explained by poor oral hygiene alone and is related to changes in the immune response. The aim of this study is to evaluate whether DS w
Autor:
Anna Babour, Luciano H. Apponi, Thanasis Margaritis, Catherine Dargemont, Adeline Vitaliano-Prunier, Frank C. P. Holstege, Anita H. Corbett, Lucas Hérissant, Carole Gwizdek
Publikováno v:
Molecular Cell
Molecular Cell, Elsevier, 2012, 45 (1), pp.132-9. ⟨10.1016/j.molcel.2011.12.011⟩
Molecular Cell, Elsevier, 2012, 45 (1), pp.132-139. ⟨10.1016/j.molcel.2011.12.011⟩
Molecular Cell, Elsevier, 2012, 45 (1), pp.132-9. ⟨10.1016/j.molcel.2011.12.011⟩
Molecular Cell, Elsevier, 2012, 45 (1), pp.132-139. ⟨10.1016/j.molcel.2011.12.011⟩
International audience; Histone H2B ubiquitylation is a transcription-dependent modification that not only regulates nucleosome dynamics but also controls the trimethylation of histone H3 on lysine 4 by promoting ubiquitylation of Swd2, a component o
Autor:
Farkhondeh Behjati, Seyedeh Sedigheh Abedini, Gary J. Bassell, Subhabrata Sanyal, Hans-Hilger Ropers, Guanglu Liu, Lars Riff Jensen, Brenda Huang, Kenneth H. Moberg, Kathryn R. Williams, Hossein Najmabadi, Andreas W. Kuss, Anita H. Corbett, K. Kahrizi, Hao Hu, Luciano H. Apponi, Sara N Stahley, Seth M. Kelly, Andreas Tzschach, ChangHui Pak, Masoud Garshasbi, Yue Feng, Sara W. Leung, Christina Gross, Marzieh Mohseni, Sharon K. Burdick, John J Noto
Publikováno v:
Proceedings of the National Academy of Sciences. 108:12390-12395
Here we report a human intellectual disability disease locus on chromosome 14q31.3 corresponding to mutation of the ZC3H14 gene that encodes a conserved polyadenosine RNA binding protein. We identify ZC3H14 mRNA transcripts in the human central nervo