Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Luciano Conti"'
Autor:
Dilara Ayyildiz, Guendalina Bergonzoni, Alan Monziani, Takshashila Tripathi, Jessica Döring, Emanuela Kerschbamer, Francesca Di Leva, Elia Pennati, Luisa Donini, Marina Kovalenko, Jacopo Zasso, Luciano Conti, Vanessa C Wheeler, Christoph Dieterich, Silvano Piazza, Erik Dassi, Marta Biagioli
Publikováno v:
PLoS Genetics, Vol 19, Iss 10, p e1010988 (2023)
Alternative splicing (AS) appears to be altered in Huntington's disease (HD), but its significance for early, pre-symptomatic disease stages has not been inspected. Here, taking advantage of Htt CAG knock-in mouse in vitro and in vivo models, we demo
Externí odkaz:
https://doaj.org/article/87731a943eda4263b60cff414dc33cfe
Autor:
Alessandro Umbach, Giulia Maule, Eyemen Kheir, Alessandro Cutarelli, Marika Foglia, Luca Guarrera, Luca L. Fava, Luciano Conti, Enrico Garattini, Mineko Terao, Anna Cereseto
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-13 (2022)
Abstract Background Cornelia de Lange syndrome (CdLS) is a rare multisystem genetic disorder which is caused by genetic defects involving the Nipped-B-like protein (NIPBL) gene in the majority of clinical cases (60–70%). Currently, there are no spe
Externí odkaz:
https://doaj.org/article/a3317733e436485fa7844778aed951b2
Publikováno v:
Frontiers in Neuroanatomy, Vol 17 (2023)
Externí odkaz:
https://doaj.org/article/81365e1816a54f4ba2151a2cb7060516
Autor:
Francesco Antonica, Lucia Santomaso, Davide Pernici, Linda Petrucci, Giuseppe Aiello, Alessandro Cutarelli, Luciano Conti, Alessandro Romanel, Evelina Miele, Toma Tebaldi, Luca Tiberi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract Pediatric and adult high-grade gliomas are the most common primary malignant brain tumors, with poor prognosis due to recurrence and tumor infiltration after therapy. Quiescent cells have been implicated in tumor recurrence and treatment res
Externí odkaz:
https://doaj.org/article/43efb7b47c3b48e68e112be0007905f9
Autor:
Marilyn M. Angulo Salavarria, Claudia Dell’Amico, Armando D’Agostino, Luciano Conti, Marco Onorati
Publikováno v:
Frontiers in Neuroanatomy, Vol 17 (2023)
The human brain is the most complex structure generated during development. Unveiling the ontogenesis and the intrinsic organization of specific neural networks may represent a key to understanding the physio-pathological aspects of different brain a
Externí odkaz:
https://doaj.org/article/cb8a78f4732f4143ae083372a86fd52d
Publikováno v:
Ensaio Pesquisa em Educação em Ciências, Vol 24 (2022)
RESUMO: A investigação desenvolvida objetivou: analisar os conteúdos abordados pelas disciplinas de astronomia em universidades públicas do país, ora separado por esfera federal ou estadual, ora comparativamente, no intuito de se compreender qua
Externí odkaz:
https://doaj.org/article/32d99c4851e2417a90320def3ae398c4
Autor:
Valentina Gilmozzi, Giovanna Gentile, Diana A. Riekschnitz, Michael Von Troyer, Alexandros A. Lavdas, Emanuela Kerschbamer, Christian X. Weichenberger, Marcelo D. Rosato-Siri, Simona Casarosa, Luciano Conti, Peter P. Pramstaller, Andrew A. Hicks, Irene Pichler, Alessandra Zanon
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Human induced pluripotent stem cells (hiPSCs) represent an unlimited cell source for the generation of patient-specific dopaminergic (DA) neurons, overcoming the hurdle of restricted accessibility to disease-affected tissue for mechanistic studies on
Externí odkaz:
https://doaj.org/article/1b46ad349975430cac3e8b75a86ac04d
Autor:
Daniele Pollini, Rosa Loffredo, Marina Cardano, Luciano Conti, Serena Lattante, Angelantonio Notarangelo, Mario Sabatelli, Alessandro Provenzani
Publikováno v:
Stem Cell Research, Vol 33, Iss , Pp 146-150 (2018)
Fibroblasts isolated from an Amyotrophic Lateral Sclerosis (ALS)-patient carrying a mutation in Matrin-3 (p.Q66K -MATR3) gene were reprogrammed to the pluripotency stage by using non-integrating episomal plasmids. We generated the Q66K#44DRM induced
Externí odkaz:
https://doaj.org/article/43ea32276e9c41f0b9f93725601b2c25
Autor:
Daniele Pollini, Rosa Loffredo, Federica Maniscalco, Marina Cardano, Mariachiara Micaelli, Isabelle Bonomo, Nausicaa Valentina Licata, Daniele Peroni, Weronika Tomaszewska, Annalisa Rossi, Valeria Crippa, Erik Dassi, Gabriella Viero, Alessandro Quattrone, Angelo Poletti, Luciano Conti, Alessandro Provenzani
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102197- (2021)
Summary: Matrin3 (MATR3) is a nuclear RNA/DNA-binding protein that plays pleiotropic roles in gene expression regulation by directly stabilizing target RNAs and supporting the activity of transcription factors by modulating chromatin architecture. MA
Externí odkaz:
https://doaj.org/article/9fcad58d9cd74704a77b3694b80e79df
Autor:
Matteo Marcatili, Carlo Sala, Antonios Dakanalis, Fabrizia Colmegna, Armando D’Agostino, Orsola Gambini, Bernardo Dell’Osso, Beatrice Benatti, Luciano Conti, Massimo Clerici
Publikováno v:
Therapeutic Advances in Psychopharmacology, Vol 10 (2020)
Approximately 30% of Major Depressive Disorder (MDD) patients develop treatment-resistant depression (TRD). Among the different causes that make TRD so challenging in both clinical and research contexts, major roles are played by the inadequate under
Externí odkaz:
https://doaj.org/article/5c66001891c54713b1ed607ae3e3e979