Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Luciane T. Kagohara"'
Autor:
Inês Godet, Harsh H. Oza, Yi Shi, Natalie S. Joe, Alyssa G. Weinstein, Jeanette Johnson, Michael Considine, Swathi Talluri, Jingyuan Zhang, Reid Xu, Steven Doctorman, Delma Mbulaiteye, Genevieve Stein-O’Brien, Luciane T. Kagohara, Cesar A. Santa-Maria, Elana J. Fertig, Daniele M. Gilkes
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Hypoxia occurs in 90% of solid tumors and is associated with metastasis and mortality. Breast cancer cells that experience intratumoral hypoxia are 5x more likely to develop lung metastasis in animal models. Using spatial transcriptomics, we
Externí odkaz:
https://doaj.org/article/426e0d8a44dd43e7bc5d581380aed53f
Autor:
Shuming Zhang, Long Yuan, Ludmila Danilova, Guanglan Mo, Qingfeng Zhu, Atul Deshpande, Alexander T. F. Bell, Jennifer Elisseeff, Aleksander S. Popel, Robert A. Anders, Elizabeth M. Jaffee, Mark Yarchoan, Elana J. Fertig, Luciane T. Kagohara
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background Novel immunotherapy combination therapies have improved outcomes for patients with hepatocellular carcinoma (HCC), but responses are limited to a subset of patients. Little is known about the inter- and intra-tumor heterogeneity i
Externí odkaz:
https://doaj.org/article/098a7d924d184c9b829632f226e3bd36
Autor:
George J. Xu, Matthew A. Loberg, Jean-Nicolas Gallant, Quanhu Sheng, Sheau-Chiann Chen, Brian D. Lehmann, Sophia M. Shaddy, Megan L. Tigue, Courtney J. Phifer, Li Wang, Mario W. Saab-Chalhoub, Lauren M. Dehan, Qiang Wei, Rui Chen, Bingshan Li, Christine Y. Kim, Donna C. Ferguson, James L. Netterville, Sarah L. Rohde, Carmen C. Solórzano, Lindsay A. Bischoff, Naira Baregamian, Aaron C. Shaver, Mitra Mehrad, Kim A. Ely, Daniel W. Byrne, Thomas P. Stricker, Barbara A. Murphy, Jennifer H. Choe, Luciane T. Kagohara, Elizabeth M. Jaffee, Eric C. Huang, Fei Ye, Ethan Lee, Vivian L. Weiss
Publikováno v:
Cell Genomics, Vol 3, Iss 10, Pp 100409- (2023)
Summary: Genomic and transcriptomic analysis has furthered our understanding of many tumors. Yet, thyroid cancer management is largely guided by staging and histology, with few molecular prognostic and treatment biomarkers. Here, we utilize a large c
Externí odkaz:
https://doaj.org/article/fc1b6ef5686b46cf86fe3857f3b602c5
Autor:
Daniel Delitto, Daniel J. Zabransky, Fangluo Chen, Elizabeth D. Thompson, Jacquelyn W. Zimmerman, Todd D. Armstrong, James M. Leatherman, Reecha Suri, Tamara Y. Lopez-Vidal, Amanda L. Huff, Melissa R. Lyman, Samantha R. Guinn, Marina Baretti, Luciane T. Kagohara, Won Jin Ho, Nilofer S. Azad, William R. Burns, Jin He, Christopher L. Wolfgang, Richard A. Burkhart, Lei Zheng, Mark Yarchoan, Neeha Zaidi, Elizabeth M. Jaffee
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Tumor involvement of major vascular structures limits surgical options in pancreatic adenocarcinoma (PDAC), which in turn limits opportunities for cure. Despite advances in locoregional approaches, there is currently no role for incomplete resection.
Externí odkaz:
https://doaj.org/article/97094383247048c2ade5ce77d37edcab
Autor:
Tatiana Lopatina, Enrica Favaro, Ludmila Danilova, Elana J. Fertig, Alexander V. Favorov, Luciane T. Kagohara, Tiziana Martone, Benedetta Bussolati, Renato Romagnoli, Roberto Albera, Giancarlo Pecorari, Maria Felice Brizzi, Giovanni Camussi, Daria A. Gaykalova
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Head and neck squamous cell carcinoma (HNSCC) has a high recurrence and metastatic rate with an unknown mechanism of cancer spread. Tumor inflammation is the most critical processes of cancer onset, growth, and metastasis. We hypothesize that the rel
Externí odkaz:
https://doaj.org/article/3f57d57f6592444bb1d03d52e863e046
Autor:
Genevieve Stein-O’Brien, Luciane T. Kagohara, Sijia Li, Manjusha Thakar, Ruchira Ranaweera, Hiroyuki Ozawa, Haixia Cheng, Michael Considine, Sandra Schmitz, Alexander V. Favorov, Ludmila V. Danilova, Joseph A. Califano, Evgeny Izumchenko, Daria A. Gaykalova, Christine H. Chung, Elana J. Fertig
Publikováno v:
Genome Medicine, Vol 10, Iss 1, Pp 1-22 (2018)
Abstract Background Targeted therapies specifically act by blocking the activity of proteins that are encoded by genes critical for tumorigenesis. However, most cancers acquire resistance and long-term disease remission is rarely observed. Understand
Externí odkaz:
https://doaj.org/article/840ecdadd96d4faa9799065ff37c62d1
Autor:
Daniel J. Zabransky, Ludmila Danilova, James M. Leatherman, Tamara Y. Lopez‐Vidal, Jessica Sanchez, Soren Charmsaz, Nicole E. Gross, Sarah Shin, Xuan Yuan, Alexei Hernandez, Hongqui Yang, Stephanie Xavier, Daniel Shu, Ali Saeed, Kabeer Munjal, Zeal Kamdar, Luciane T. Kagohara, Elizabeth M. Jaffee, Mark Yarchoan, Won Jin Ho
Publikováno v:
Hepatology
BACKGROUND AND AIMS: The treatment of hepatocellular carcinoma (HCC) has been transformed by the use of immune checkpoint inhibitors. However, most patients with HCC do not benefit from treatment with immunotherapy. There is an urgent need to underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8d8e5bded14d7bc88afdbe64239061
https://europepmc.org/articles/PMC9905363/
https://europepmc.org/articles/PMC9905363/
Autor:
Evanthia T. Roussos Torres, Elana J. Fertig, Elizabeth M. Jaffee, Luciane T. Kagohara, Daria A. Gaykalova, Roisin M. Connolly, Vered Stearns, Srinivasan Yegnasubramanian, Min Yu, Sathish Kumar Ganesan, Sarah J. Wheelan, Michael Considine, Alyza Skaist, Anuj Gupta, Ajay Vaghasia, Emma Bigelow, Gaurav Sharma, Emily F. Davis-Marcisak, Valerie H. Narumi, Brian J. Christmas, Edgar Gonzalez, Aaron G. Baugh, Sofi Castanon, Julie K. Jang, Christine I. Rafie, Dimitrios N. Sidiropoulos
Supplementary Data from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2+ Breast Tumor Microenvironment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e28169c16cf94af543790c359b314a
https://doi.org/10.1158/2326-6066.22544265.v1
https://doi.org/10.1158/2326-6066.22544265.v1
Autor:
Alexander T.F. Bell, Jacob T. Mitchell, Ashley L. Kiemen, Kohei Fujikura, Helen Fedor, Bonnie Gambichler, Atul Deshpande, Pei-Hsun Wu, Dimitri N. Sidiropoulos, Rossin Erbe, Jacob Stern, Rena Chan, Stephen Williams, James M. Chell, Jacquelyn W. Zimmerman, Denis Wirtz, Elizabeth M. Jaffee, Laura D. Wood, Elana J. Fertig, Luciane T. Kagohara
Spatial transcriptomics (ST) is a powerful new approach to characterize the cellular and molecular architecture of the tumor microenvironment. Previous single-cell RNA-sequencing (scRNA-seq) studies of pancreatic ductal adenocarcinoma (PDAC) have rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9085ef0d7de016515fa044b23f9cb161
https://doi.org/10.1101/2022.07.16.500312
https://doi.org/10.1101/2022.07.16.500312
Autor:
Benedict Kinny-Köster, Samantha Guinn, Joseph A. Tandurella, Jacob T. Mitchell, Dimitrios N. Sidiropoulos, Melanie Loth, Melissa R. Lyman, Alexandra B. Pucsek, Toni T. Seppälä, Christopher Cherry, Reecha Suri, Haley Zlomke, Jin He, Christopher L. Wolfgang, Jun Yu, Lei Zheng, David P. Ryan, David T. Ting, Alec Kimmelman, Anuj Gupta, Ludmila Danilova, Jennifer H. Elisseeff, Laura D. Wood, Genevieve Stein-O’Brien, Luciane T. Kagohara, Elizabeth M. Jaffee, Richard A. Burkhart, Elana J. Fertig, Jacquelyn W. Zimmerman
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by a heterogeneous tumor microenvironment (TME) that is enriched with cancer associated fibroblasts (CAFs)1. Cell-cell interactions involving these CAFs promote an immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cc5107abd96598f6c594da5251e9ad2
https://doi.org/10.1101/2022.07.14.500096
https://doi.org/10.1101/2022.07.14.500096