Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Luciana Pelosi-Kilby"'
Autor:
Khanh Bui, James Empfield, Cindy Shen, Luciana Pelosi-Kilby, Yun W. Alelyunas, Dennis J. McCarthy, Russell C. Spreen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7312-7316
We determined the experimental solubility of CNS marketed drugs. Of the 98 drugs measured, greater than 90% had solubility >10 μM in pH 7.4 buffer. Only seven drugs had solubility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d09dd28ced1f27437c6937651057aa
https://doi.org/10.1016/j.bmcl.2010.10.068
https://doi.org/10.1016/j.bmcl.2010.10.068
Publikováno v:
Journal of Chromatography A. 1217:1950-1955
A rapid throughput octanol–water lipophilicity measurement based on 96-well shake-flask and LC/UV/APPI/MS is described. The method utilizes central liquid storage where compounds are stored as 10 mM solutions in dimethyl sulfoxide (DMSO). The DMSO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b489472ca6f8d8da846bc6de80b1e9a3
https://doi.org/10.1016/j.chroma.2010.01.071
https://doi.org/10.1016/j.chroma.2010.01.071
Publikováno v:
European Journal of Pharmaceutical Sciences. 37:172-182
A rapid throughput equilibrium solubility measurement is described. The method utilizes central liquid storage where compounds are stored as 10mM solution in dimethyl sulfoxide (DMSO). The DMSO is subsequently removed to generate solid like material
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200102b85acc93b0ebbeeeab7d0e9048
https://doi.org/10.1016/j.ejps.2009.02.007
https://doi.org/10.1016/j.ejps.2009.02.007
Publikováno v:
Analytical Methods. 3:2392
An automated method for testing the solution stability of drug discovery candidates is described. The method simultaneously tests a compound's stability over 20 h at two temperatures (37 °C and 60 °C) and at as many as six pH values ranging from pH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd6b41548a96d14b787adec8e056a5a3
https://doi.org/10.1039/c0ay00547a
https://doi.org/10.1039/c0ay00547a