Výsledky vyhledávání - "Luciana O Andrade"

Akademický článek

Cardiomyocyte oxidants production may signal to T. cruzi intracellular development.

Autor: Patrícia Pereira Dias, Rhayanne Figueiredo Capila, Natália Fernanda do Couto, Damían Estrada, Fernanda Ramos Gadelha, Rafael Radi, Lucía Piacenza, Luciana O Andrade

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 8, p e0005852 (2017)

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, presents a variable clinical course, varying from asymptomatic to serious debilitating pathologies with cardiac, digestive or cardio-digestive impairment. Previous studies using two

Externí odkaz: https://doaj.org/article/d05dc1e3298945b7ac1c48ac494f92cb

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Akademický článek

LAMP-2 absence interferes with plasma membrane repair and decreases T. cruzi host cell invasion.

Autor: Natália Fernanda Couto, Dina Pedersane, Luisa Rezende, Patrícia P Dias, Tayanne L Corbani, Lívia C Bentini, Anny C S Oliveira, Ludmila F Kelles, Thiago Castro-Gomes, Luciana O Andrade

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 6, p e0005657 (2017)

Trypanosoma cruzi enters host cells by subverting the mechanism of cell membrane repair. In this process, the parasite induces small injuries in the host cell membrane leading to calcium entry and lysosomal exocytosis, which are followed by compensat

Externí odkaz: https://doaj.org/article/80a7b37153394f6ba7927785a6f5f0e0

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Akademický článek

Differential tissue tropism of Trypanosoma cruzi strains: an in vitro study

Autor: Luciana O Andrade, Lúcia MC Galvão, Maria de Nazareth SL Meirelles, Egler Chiari, Sergio DJ Pena, Andrea M Macedo

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 105, Iss 6, Pp 834-837 (2010)

We have previously demonstrated selection favoring the JG strain of Trypanosoma cruziin hearts of BALB/c mice that were chronically infected with an equal mixture of the monoclonal JG strain and a clone of the Colombian strain, Col1.7G2. To evaluate

Externí odkaz: https://doaj.org/article/562c0830760a4d7db2ad42bd057e7f74

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Akademický článek

Oxidative stress and DNA lesions: the role of 8-oxoguanine lesions in Trypanosoma cruzi cell viability.

Autor: Pedro H N Aguiar, Carolina Furtado, Bruno M Repolês, Grazielle A Ribeiro, Isabela C Mendes, Eduardo F Peloso, Fernanda R Gadelha, Andrea M Macedo, Glória R Franco, Sérgio D J Pena, Santuza M R Teixeira, Leda Q Vieira, Alessandra A Guarneri, Luciana O Andrade, Carlos R Machado

Publikováno v: PLoS Neglected Tropical Diseases, Vol 7, Iss 6, p e2279 (2013)

The main consequence of oxidative stress is the formation of DNA lesions, which can result in genomic instability and lead to cell death. Guanine is the base that is most susceptible to oxidation, due to its low redox potential, and 8-oxoguanine (8-o

Externí odkaz: https://doaj.org/article/c3030a2328674338ab1d1c9ce0656a09

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Akademický článek

Membrane cholesterol removal changes mechanical properties of cells and induces secretion of a specific pool of lysosomes.

Autor: Barbara Hissa, Bruno Pontes, Paula Magda S Roma, Ana Paula Alves, Carolina D Rocha, Thalita M Valverde, Pedro Henrique N Aguiar, Fernando P Almeida, Allan J Guimarães, Cristina Guatimosim, Aristóbolo M Silva, Maria C Fernandes, Norma W Andrews, Nathan B Viana, Oscar N Mesquita, Ubirajara Agero, Luciana O Andrade

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e82988 (2013)

In a previous study we had shown that membrane cholesterol removal induced unregulated lysosomal exocytosis events leading to the depletion of lysosomes located at cell periphery. However, the mechanism by which cholesterol triggered these exocytic e

Externí odkaz: https://doaj.org/article/851121caba49450892984c7c7853c6ce

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Akademický článek

Membrane cholesterol regulates lysosome-plasma membrane fusion events and modulates Trypanosoma cruzi invasion of host cells.

Autor: Bárbara Hissa, Jacqueline G Duarte, Ludmila F Kelles, Fabio P Santos, Helen L del Puerto, Pedro H Gazzinelli-Guimarães, Ana M de Paula, Ubirajara Agero, Oscar N Mesquita, Cristina Guatimosim, Egler Chiari, Luciana O Andrade

Publikováno v: PLoS Neglected Tropical Diseases, Vol 6, Iss 3, p e1583 (2012)

BACKGROUND: Trypomastigotes of Trypanosoma cruzi are able to invade several types of non-phagocytic cells through a lysosomal dependent mechanism. It has been shown that, during invasion, parasites trigger host cell lysosome exocytosis, which initial

Externí odkaz: https://doaj.org/article/0111a28f2b214a35af235d80f7835776

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Akademický článek

The MHC gene region of murine hosts influences the differential tissue tropism of infecting Trypanosoma cruzi strains.

Autor: Jorge M Freitas, Luciana O Andrade, Simone F Pires, Ricardo Lima, Egler Chiari, Ricardo R Santos, Milena Soares, Carlos R Machado, Gloria R Franco, Sergio D J Pena, Andrea M Macedo

Publikováno v: PLoS ONE, Vol 4, Iss 4, p e5113 (2009)

We have previously demonstrated that both parasite genetic variability and host genetic background were important in determining the differential tissue distribution of the Col1.7G2 and JG T. cruzi monoclonal strains after artificial infections in mi

Externí odkaz: https://doaj.org/article/f37398b19dfe459a97b4b454a8523fe9

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