Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Luciana Morais Canavieira"'
Autor:
Paul V. Bernhardt, Rosivaldo S. Borges, José Rogério A. Silva, Jerônimo Lameira, Thiago de Melo e Silva, Craig M. Williams, Edikarlos Brasil, Luciana Morais Canavieira, Cláudio Nahum Alves
Publikováno v:
Molecular Simulation. 47:762-770
Tyrosinase (TYR) is a key enzyme that catalyzes the synthesis of melanin in plants, microorganisms and mammalian cells. Kojic acid (KA) is a well-known TYR inhibitor widely used as a popular cosmetic skin-lightening ingredient. However, KA is reporte
Autor:
Edikarlos Brasil, José Rogério A. Silva, José Luiz Martins do Nascimento, Cláudio Nahum Alves, Barbarella de Matos Macchi, Paul V. Bernhardt, Erica de Tássia Carvalho Cardoso, Craig M. Williams, Luciana Morais Canavieira, Vera Lucia Eifler-Lima, Edilene O. Silva, Dharmarajan Sriram, Jerônimo Lameira
Publikováno v:
Chemical biologydrug design. 90(5)
Inhibition of mushroom tyrosinase was observed with synthetic dihydropyrano[3,2-b]chromenediones. Among them, DHPC04 displayed the most potent tyrosinase inhibitory activity with a Ki value of 4μM, comparable to the reference standard inhibitor koji