Výsledky vyhledávání - "Luciana Bertholim"

Akademický článek

Characterization of pharmacogenomic variants in a Brazilian admixed cohort of elderly individuals based on whole-genome sequencing data

Autor: Luciana Bertholim-Nasciben, Marilia O. Scliar, Guilherme Debortoli, Bhooma Thiruvahindrapuram, Stephen W. Scherer, Yeda A. O. Duarte, Mayana Zatz, Guilherme Suarez-Kurtz, Esteban J. Parra, Michel S. Naslavsky

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Introduction: Research in the field of pharmacogenomics (PGx) aims to identify genetic variants that modulate response to drugs, through alterations in their pharmacokinetics (PK) or pharmacodynamics (PD). The distribution of PGx variants differs con

Externí odkaz: https://doaj.org/article/7ee46adbea8548ae8d92fc8f483239aa

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Akademický článek

Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases

Autor: Amanda F. Asega, Milene C. Menezes, Dilza Trevisan-Silva, Daniela Cajado-Carvalho, Luciana Bertholim, Ana K. Oliveira, André Zelanis, Solange M. T. Serrano

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)

Abstract Envenoming by viperid snakes results in a complex pattern of tissue damage, including hemorrhage, which in severe cases may lead to permanent sequelae. Snake venom metalloproteinases (SVMPs) are main players in this pathogenesis, acting syne

Externí odkaz: https://doaj.org/article/bc9c2fbbe69d4ad8ab8d829248f79dbe

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Akademický článek

Systemic Effects of Hemorrhagic Snake Venom Metalloproteinases: Untargeted Peptidomics to Explore the Pathodegradome of Plasma Proteins

Autor: Luciana Bertholim, Alison F. A. Chaves, Ana K. Oliveira, Milene C. Menezes, Amanda F. Asega, Alexandre K. Tashima, Andre Zelanis, Solange M. T. Serrano

Publikováno v: Toxins, Vol 13, Iss 11, p 764 (2021)

Hemorrhage induced by snake venom metalloproteinases (SVMPs) is a complex phenomenon that involves capillary disruption and blood extravasation. HF3 (hemorrhagic factor 3) is an extremely hemorrhagic SVMP of Bothrops jararaca venom. Studies using pro

Externí odkaz: https://doaj.org/article/32f8cf74497f4036b23d6d4e2bae528f

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Dissertation/ Thesis

Análise proteômica da atividade proteolítica do HF3, uma metaloproteinase do veneno da Bothrops jararaca, no plasma humano e de serpente

Autor: Luciana Bertholim Nasciben

Publikováno v: Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.

A hemorragia gerada por metaloproteinases de venenos de serpentes é um fenômeno complexo que resulta na ruptura de capilares e extravasamento de sangue. O HF3 (fator hemorrágico 3) é uma metaloproteinase da classe P-IIIa, extremamente hemorrágic

Externí odkaz: http://www.teses.usp.br/teses/disponiveis/46/46131/tde-20012015-083705/

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Akademický článek

Vaccines are different: A systematic review of budget impact analyses of vaccines

Autor: Loze, Priscilla Magalhaes, Nasciben, Luciana Bertholim, Sartori, Ana Marli Christovam, Itria, Alexander, Novaes, Hillegonda Maria Dutilh, de Soárez, Patrícia Coelho

Publikováno v: In Vaccine 15 May 2017 35(21):2781-2793

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Pharmacogenetic markers based on genomic data from a cohort of elderly individuals from the city of São Paulo and the landscape of pharmacogenomics research in Brazil

Autor: Luciana Bertholim Nasciben

Publikováno v: Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP

A medicina de precisão trata-se de uma área tem avançado rapidamente nos últimos anos, juntamente com o desenvolvimento de novas tecnologias de diagnóstico e tratamento, levando à minimização de efeitos colaterais relacionados ao tratamento m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8181133859fef269dab727892320d32

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Systemic Effects of Hemorrhagic Snake Venom Metalloproteinases: Untargeted Peptidomics to Explore the Pathodegradome of Plasma Proteins

Autor: Alexandre Keiji Tashima, André Zelanis, Solange M.T. Serrano, Amanda F. Asega, Alison F A Chaves, Milene C. Menezes, Ana Oliveira, Luciana Bertholim

Publikováno v: Toxins, Vol 13, Iss 764, p 764 (2021)
Toxins
Volume 13
Issue 11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2123a757704e48e17865859bd5c85981
https://www.mdpi.com/2072-6651/13/11/764

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Dissertation/ Thesis

Análise proteômica da atividade proteolítica do HF3, uma metaloproteinase do veneno da Bothrops jararaca, no plasma humano e de serpente

Autor: Nasciben, Luciana Bertholim

Externí odkaz: http://www.teses.usp.br/teses/disponiveis/46/46131/tde-20012015-083705/

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Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases

Autor: Dilza Trevisan-Silva, Daniela Cajado-Carvalho, Ana Oliveira, Milene C. Menezes, Luciana Bertholim, André Zelanis, Amanda F. Asega, Solange M.T. Serrano

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)

Envenoming by viperid snakes results in a complex pattern of tissue damage, including hemorrhage, which in severe cases may lead to permanent sequelae. Snake venom metalloproteinases (SVMPs) are main players in this pathogenesis, acting synergistical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b15fc381527b3f45efb3cea9f2cffc
https://doi.org/10.1038/s41598-020-69396-y

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Vaccines are different: A systematic review of budget impact analyses of vaccines

Autor: Patrícia Coelho de Soárez, Hillegonda Maria Dutilh Novaes, Luciana Bertholim Nasciben, Alexander Itria, Priscilla Magalhães Loze, Ana Marli Christovam Sartori

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Introduction Several countries require manufacturers to present a budget impact analysis (BIA), together with a cost-effectiveness analysis, to support national funding requests. However, guidelines for conducting BIA of vaccines are scarce. Objectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3a1f89375061a1163e3861c16df306

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