Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Luciana Marinelli"'
Autor:
Elisa Facen, Giulia Assoni, Greta Donati, Dalila Paladino, Agata Carreira, Isabelle Bonomo, Valeria La Pietra, Roberta Lotti, Josef Houser, Luca L. Fava, Pierfausto Seneci, Luciana Marinelli, Daniela Arosio, Alessandro Provenzani
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract The RNA binding protein Human Antigen R (HuR) has been identified as a main regulator of the innate immune response and its inhibition can lead to beneficial anti-inflammatory effects. To this aim, we previously synthesized a novel class of
Externí odkaz:
https://doaj.org/article/bdf3a13a957a4cdb8e0be0dcf65c60d7
Autor:
Antonella Damiana Recchia, Alessandra Dominicis, Vincenzo Maria D'Amore, Tommaso Fabiano, Aland Ibrahim Ahmed Al Jaf, Simone Peria, Francesco Basoli, Alberto Rainer, Luciana Marinelli, Francesco Saverio Di Leva, Antonella Ragnini-Wilson
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
BackgroundThe myelin sheath ensures efficient nerve impulse transmission along the axons. Remyelination is a spontaneous process that restores axonal insulation, promoting neuroprotection and recovery after myelin damage. There is an urgent need for
Externí odkaz:
https://doaj.org/article/45fa46653945400e9c244adbeffd261c
Autor:
Stefano Cinti, Stefano Tomassi, Chiara Ciardiello, Rossella Migliorino, Marinella Pirozzi, Alessandra Leone, Elena Di Gennaro, Virginia Campani, Giuseppe De Rosa, Vincenzo Maria D’Amore, Salvatore Di Maro, Greta Donati, Sima Singh, Ada Raucci, Francesco Saverio Di Leva, Horst Kessler, Alfredo Budillon, Luciana Marinelli
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Despite progress in the prevention and diagnosis of cancer, current technologies for tumor detection present several limitations including invasiveness, toxicity, inaccuracy, lengthy testing duration and high cost. Therefore, innovative diag
Externí odkaz:
https://doaj.org/article/252fb9bb04114559aa178aea6715169a
Autor:
Greta Donati, Vincenzo Maria D’Amore, Pasquale Russomanno, Linda Cerofolini, Jussara Amato, Simona Marzano, Maria Salobehaj, Domenico Rizzo, Giulia Assoni, Alfonso Carotenuto, Valeria La Pietra, Daniela Arosio, Pierfausto Seneci, Marco Fragai, Diego Brancaccio, Francesco Saverio Di Leva, Luciana Marinelli
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3355-3368 (2023)
Today it is widely recognized that the PD-1/PD-L1 axis plays a fundamental role in escaping the immune system in cancers, so that anti-PD-1/PD-L1 antibodies have been evaluated for their antitumor properties in more than 1000 clinical trials. As a re
Externí odkaz:
https://doaj.org/article/3bd14ba4f0aa401ca2a63ca4a266835e
Autor:
Isabelle Bonomo, Giulia Assoni, Valeria La Pietra, Giulia Canarutto, Elisa Facen, Greta Donati, Chiara Zucal, Silvia Genovese, Mariachiara Micaelli, Anna Pérez-Ràfols, Sergio Robbiati, Dimitris L. Kontoyannis, Marilenia De Matteo, Marco Fragai, Pierfausto Seneci, Luciana Marinelli, Daniela Arosio, Silvano Piazza, Alessandro Provenzani
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 3 (2023)
Externí odkaz:
https://doaj.org/article/f46f5530b8b347c99a98e099c85d727f
Autor:
Luca Muzio, Riccardo Sirtori, Davide Gornati, Simona Eleuteri, Andrea Fossaghi, Diego Brancaccio, Leonardo Manzoni, Linda Ottoboni, Luca De Feo, Angelo Quattrini, Eloise Mastrangelo, Luca Sorrentino, Emanuele Scalone, Giancarlo Comi, Luciana Marinelli, Nilo Riva, Mario Milani, Pierfausto Seneci, Gianvito Martino
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
ALS is a neurodegenerative disease characterized by loss of motor neurons. Here, the authors showed that reduced levels of the VSP35 subunit in the retromer complex is a conserved ALS feature and identified a new lead compound increasing retromer sta
Externí odkaz:
https://doaj.org/article/2a79c2c4685b4d2598d773092d995d7b
Autor:
Elisa Nuti, Valeria La Pietra, Simona Daniele, Doretta Cuffaro, Lidia Ciccone, Chiara Giacomelli, Carolina Cason, Alfonso Carotenuto, Vincenzo Maria D’Amore, Eleonora Da Pozzo, Barbara Costa, Riccardo Di Leo, Manola Comar, Luciana Marinelli, Claudia Martini, Armando Rossello
Publikováno v:
Pharmaceuticals, Vol 15, Iss 11, p 1318 (2022)
Intracellular pathogens, such as Chlamydia trachomatis, have been recently shown to induce degradation of p53 during infection, thus impairing the protective response of the host cells. Therefore, p53 reactivation by disruption of the p53–MDM2 comp
Externí odkaz:
https://doaj.org/article/6617491cc612473bbc9d99a6af5636a2
Autor:
Ivana Barravecchia, Elisabetta Barresi, Camilla Russo, Francesca Scebba, Chiara De Cesari, Valerio Mignucci, Davide De Luca, Silvia Salerno, Valeria La Pietra, Mariateresa Giustiniano, Sveva Pelliccia, Diego Brancaccio, Greta Donati, Federico Da Settimo, Sabrina Taliani, Debora Angeloni, Luciana Marinelli
Publikováno v:
Molecules, Vol 26, Iss 24, p 7519 (2021)
Molecule interacting with CasL 2 (MICAL2), a cytoskeleton dynamics regulator, are strongly expressed in several human cancer types, especially at the invasive front, in metastasizing cancer cells and in the neo-angiogenic vasculature. Although a plet
Externí odkaz:
https://doaj.org/article/8dae666ae0a641799df6e215c072523e
Autor:
Isabelle Bonomo, Giulia Assoni, Valeria La Pietra, Giulia Canarutto, Elisa Facen, Greta Donati, Chiara Zucal, Silvia Genovese, Mariachiara Micaelli, Anna Pérez-Ràfols, Sergio Robbiati, Dimitris L. Kontoyannis, Marilenia De Matteo, Marco Fragai, Pierfausto Seneci, Luciana Marinelli, Daniela Arosio, Silvano Piazza, Alessandro Provenzani
Lipopolysaccharide exposure to macrophages induces an inflammatory response that is heavily regulated at the transcriptional and post-transcriptional levels. HuR (ELAVL1) is an RNA binding protein that binds and regulates the maturation and half-life
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41301d83518b6abcd82afc44a44b97b0
https://doi.org/10.1101/2023.01.16.524289
https://doi.org/10.1101/2023.01.16.524289
Autor:
Stefano Tomassi, Francesco Saverio Di Leva, Giovanna Musco, Salvatore Di Maro, Horst Kessler, Michael Weinmüller, Tatiana Gianni, Barbara Romano, Jussara Amato, Giacomo Quilici, Ettore Novellino, Angelo A. Izzo, Andrea Vannini, Florian Reichart, Vincenzo Maria D'Amore, Luciana Marinelli
Publikováno v:
Journal of Medicinal Chemistry
Over recent years, αvβ6 and αvβ8 Arg-Gly-Asp (RGD) integrins have risen to prominence as interchangeable co-receptors for the cellular entry of herpes simplex virus-1 (HSV-1). In fact, the employment of subtype-specific integrin-neutralizing anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42f6cb9eb13e7fb7a87091815b81a6fb
https://doi.org/10.1021/acs.jmedchem.1c00533
https://doi.org/10.1021/acs.jmedchem.1c00533