Molecular Diversity by Olefin Cross-Metathesis on Solid Support. Generation of Libraries of Biologically Promising β-Lactam Derivatives

Autor: Luciana Méndez, Andrés A. Poeylaut-Palena, Ernesto G. Mata

Publikováno v: Molecules, Vol 23, Iss 5, p 1193 (2018)

The application of the reagent-based diversification strategy for generation of libraries of biologically promising β-lactam derivatives is described. Key features are the versatility of the linker used and the cross-metathesis functionalization at

Externí odkaz: https://doaj.org/article/a92261711e814fc7a6d24a6a10407ace

Searching for improved mimetic peptides inhibitors preventing conformational transition of amyloid-β 42 monomer

Autor: Zsolt Bozsó, Lívia Fülöp, Ernesto G. Mata, Titanilla Szögi, Ana M. Rodríguez, Luciana Méndez, Federica Cioffi, Kerensa Broersen, János Gera, Gábor Paragi, Carina M. L. Delpiccolo, Exequiel Barrera, Ricardo D. Enriz

Publikováno v: Bioorganic Chemistry, 81, 211-221. Academic Press

A series of novel mimetic peptides were designed, synthesised and biologically evaluated as inhibitors of Aβ 42 aggregation. One of the synthesised peptidic compounds, termed compound 7 modulated Aβ 42 aggregation as demonstrated by thioflavin T fl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9567179e76932f90539aa2c94effaf53
https://www.sciencedirect.com/science/article/pii/S004520681830573X

Solid-Supported Cross-Metathesis and a Formal Alkane Metathesis for the Generation of Biologically Relevant Molecules

Autor: Luciana Méndez, Ernesto G. Mata

Publikováno v: ACS Combinatorial Science. 17:81-86

Solid-phase synthetic strategies towards the generation of libraries of biologically relevant molecules were developed using olefin cross-metathesis as a key step. It is remarkably the formal alkane metathesis based on a one-pot, microwave-assisted,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d14365da194a35a2e3832d596e73560b
https://doi.org/10.1021/co500176b

Unprecedented Multifunctionality of Grubbs and Hoveyda–Grubbs Catalysts: Competitive Isomerization, Hydrogenation, Silylation and Metathesis Occurring in Solution and on Solid Phase

Autor: Luciana Méndez, Ileana Dragutan, Maitena Martinez-Amezaga, Ernesto G. Mata, Valerian Dragutan, Carina M. L. Delpiccolo

Publikováno v: Catalysts, Vol 7, Iss 4, p 111 (2017)
RepHipUNR (UNR)
Universidad Nacional de Rosario
instacron:UNR
Catalysts; Volume 7; Issue 4; Pages: 111
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

This contribution showcases the interplay of several non-metathetic reactions (isomerization, silylation and “hydrogen-free” reduction) with metathesis in systems comprising a functionalized olefin and a soluble or resin-immobilized silane. These

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1a2b4cede25688c63874350063270d
http://www.mdpi.com/2073-4344/7/4/111

Synthesis of Multicyclic β-Lactam Derivatives via Solid-Phase-Generated Ketenes

Autor: Luciana Méndez, Ernesto G. Mata

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

An efficient approach for the solid-phase synthesis of multicyclic â-lactam derivatives is described. The key step is the cycloaddition reaction between an immobilized ketene and different cyclic imines to afford the corresponding benzofused carbace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbcedde679bf9a8514614c22a6c0423f
https://doi.org/10.1021/cc100140r