Zobrazeno 1 - 10 of 54 pro vyhledávání: '"Luciana, Gavernet"'
1
Akademický článek
In Silico Screening Identification of Fatty Acids and Fatty Acid Derivatives with Antiseizure Activity: In Vitro and In Vivo Validation
Autor: Emilia Mercedes Barrionuevo, Estefanía Peralta, Agustín Manzur De Nardi, Juliana Monat, Maximiliano José Fallico, Manuel Augusto Llanos, Luciana Gavernet, Emilio Román Mustafá, Pedro Martin, Alan Talevi
Publikováno v: Pharmaceutics, Vol 16, Iss 8, p 996 (2024)
High fat diets have been used as complementary treatments for seizure disorders for more than a century. Moreover, many fatty acids and derivatives, including the broad-spectrum antiseizure medication valproic acid, have been explored and used as pha
Externí odkaz: https://doaj.org/article/6fe876637a774c5e95152b973dc0af80
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2
Akademický článek
Garbage in, garbage out: how reliable training data improved a virtual screening approach against SARS-CoV-2 MPro
Autor: Santiago M. Ruatta, Denis N. Prada Gori, Martín Fló Díaz, Franca Lorenzelli, Karen Perelmuter, Lucas N. Alberca, Carolina L. Bellera, Andrea Medeiros, Gloria V. López, Mariana Ingold, Williams Porcal, Estefanía Dibello, Irina Ihnatenko, Conrad Kunick, Marcelo Incerti, Martín Luzardo, Maximiliano Colobbio, Juan Carlos Ramos, Eduardo Manta, Lucía Minini, María Laura Lavaggi, Paola Hernández, Jonas Šarlauskas, César Sebastian Huerta García, Rafael Castillo, Alicia Hernández-Campos, Giovanni Ribaudo, Giuseppe Zagotto, Renzo Carlucci, Noelia S. Medrán, Guillermo R. Labadie, Maitena Martinez-Amezaga, Carina M. L. Delpiccolo, Ernesto G. Mata, Laura Scarone, Laura Posada, Gloria Serra, Theodora Calogeropoulou, Kyriakos Prousis, Anastasia Detsi, Mauricio Cabrera, Guzmán Alvarez, Adrián Aicardo, Verena Araújo, Cecilia Chavarría, Lucija Peterlin Mašič, Melisa E. Gantner, Manuel A. Llanos, Santiago Rodríguez, Luciana Gavernet, Soonju Park, Jinyeong Heo, Honggun Lee, Kyu-Ho Paul Park, Mariela Bollati-Fogolín, Otto Pritsch, David Shum, Alan Talevi, Marcelo A. Comini
Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)
Introduction: The identification of chemical compounds that interfere with SARS-CoV-2 replication continues to be a priority in several academic and pharmaceutical laboratories. Computational tools and approaches have the power to integrate, process
Externí odkaz: https://doaj.org/article/37a7aaacc38c4e40801eaddd5b8743ba
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3
Akademický článek
A structure-based approach towards the identification of novel antichagasic compounds: Trypanosoma cruzi carbonic anhydrase inhibitors
Autor: Manuel A. Llanos, María L. Sbaraglini, María L. Villalba, María D. Ruiz, Carolina Carrillo, Catalina Alba Soto, Alan Talevi, Andrea Angeli, Seppo Parkkila, Claudiu T. Supuran, Luciana Gavernet
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 21-30 (2020)
Trypanosoma cruzi carbonic anhydrase (TcCA) has recently emerged as an interesting target for the design of new compounds to treat Chagas disease. In this study we report the results of a structure-based virtual screening campaign to identify novel a
Externí odkaz: https://doaj.org/article/dee7f4b784564aba8739454d2aa6fa17
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4
Akademický článek
Design, synthesis and biological evaluation of N-substituted α-hydroxyimides and 1,2,3-oxathiazolidine-4-one-2,2-dioxides with anticonvulsant activity
Autor: Laureano L. Sabatier, Pablo H. Palestro, Andrea V. Enrique, Valentina Pastore, María L. Sbaraglini, Pedro Martín, Luciana Gavernet
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1465-1473 (2019)
In this investigation, we studied a family of compounds with an oxathiazolidine-4-one-2,2-dioxide skeleton and their amide synthetic precursors as new anticonvulsant drugs. The cyclic structures were synthesized using a three-step protocol that inclu
Externí odkaz: https://doaj.org/article/3c42b18be86d479aa0e8cad184ce6135
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5
Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid
Autor: Federico M Garofalo, María L Sbaraglini, Emilia M Barrionuevo, Estefanía Peralta, Evelyn L Bonifazi, Alan Talevi, Luciana Gavernet
Publikováno v: Future Medicinal Chemistry. 15:735-743
Background: New hybrid compounds were synthesized by linking the valproic acid (VPA) structure with other anticonvulsant/anti-inflammatory scaffolds. Materials & methods: The chemistry involved the incorporation of the linker oxymethyl ester into VPA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8042179893e7e330ddefc0a2f1bad774
https://doi.org/10.4155/fmc-2022-0222
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6
Akademický článek
Cannabidiol (CBD) Inhibited Rhodamine-123 Efflux in Cultured Vascular Endothelial Cells and Astrocytes Under Hypoxic Conditions
Autor: Jerónimo Auzmendi, Pablo Palestro, Agustín Blachman, Luciana Gavernet, Amalia Merelli, Alan Talevi, Graciela Cristina Calabrese, Alberto Javier Ramos, Alberto Lazarowski
Publikováno v: Frontiers in Behavioral Neuroscience, Vol 14 (2020)
Despite the constant development of new antiepileptic drugs (AEDs), more than 30% of patients develop refractory epilepsy (RE) characterized by a multidrug-resistant (MDR) phenotype. The “transporters hypothesis” indicates that the mechanism of t
Externí odkaz: https://doaj.org/article/ccd53225c4384b8bb0d41b402b457b71
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9
Computational and Synthetic Target-based Approaches to the Discovery of Novel Anticonvulsant Compounds
Autor: Federico Mariano Garofalo, Melisa Edith Gantner, Maria Villalba, Manuel A. Llanos, Luciana Gavernet
Publikováno v: Current Medicinal Chemistry. 28:6866-6894
Background: During the past decades, an important number of anticonvulsant drugs have been incorporated into the collection of drugs to treat epilepsy. However, two main difficulties remain unsolved in therapy: the development of drug-resistant epile
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b0e6633ec3dd8e930fc957175c8462
https://doi.org/10.2174/0929867328666210506161234
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10
Strengths and Weaknesses of Docking Simulations in the SARS-CoV-2 Era: the Main Protease (Mpro) Case Study
Autor: Alan Talevi, Lucas Nicolás Alberca, Carolina Leticia Bellera, Santiago Rodríguez, Luciana Gavernet, Melisa Edith Gantner, Manuel A. Llanos
Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
The scientific community is working against the clock to arrive at therapeutic interventions to treat patients with COVID-19. Among the strategies for drug discovery, virtual screening approaches have the capacity to search potential hits within mill
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636afbde8150d6e1743cf239ee64a1b1
https://doi.org/10.1021/acs.jcim.1c00404
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