Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Lucian MOLDOVAN"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Replication stress compromises genomic integrity. Fork blocking lesions such as those induced by cisplatin and other chemotherapeutic agents arrest replication forks. Repriming downstream of these lesions represents an important mechanism of
Externí odkaz:
https://doaj.org/article/91581a74d5184f80833b47a45c7b283a
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Accumulation of single stranded DNA (ssDNA) gaps in the nascent strand during DNA replication has been associated with cytotoxicity and hypersensitivity to genotoxic stress, particularly upon inactivation of the BRCA tumor suppressor pathway
Externí odkaz:
https://doaj.org/article/fd6a77a2b70d4ad48b428ac71575a32e
Autor:
Wendy Leung, Ryan M. Baxley, Emma Traband, Ya-Chu Chang, Colette B. Rogers, Liangjun Wang, Wesley Durrett, Kendall S. Bromley, Lidia Fiedorowicz, Tanay Thakar, Anika Tella, Alexandra Sobeck, Eric A. Hendrickson, George-Lucian Moldovan, Naoko Shima, Anja-Katrin Bielinsky
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113523- (2023)
Summary: Ubiquitination of proliferating cell nuclear antigen (PCNA) at lysine 164 (K164) activates DNA damage tolerance pathways. Currently, we lack a comprehensive understanding of how PCNA K164 ubiquitination promotes genome stability. To evaluate
Externí odkaz:
https://doaj.org/article/0ee3d1a6203142ac8d65a9bb37a15e23
Autor:
Tanay Thakar, Ashna Dhoonmoon, Joshua Straka, Emily M. Schleicher, Claudia M. Nicolae, George-Lucian Moldovan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Efficient DNA replication is crucial for genome stability. Here, Thakar et al. report that accumulation of lagging strand ssDNA gaps during replication interferes with nucleosome assembly and drives replication fork degradation in BRCA-deficient cell
Externí odkaz:
https://doaj.org/article/2dd4e50ca1d340f4ae9cf8bf31f43a9d
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Protection of replication forks against nucleolytic degradation is crucial for genome stability. Here, Dhoonmoon et al identify PARP14 and the KU complex as essential regulators of fork degradation by MRE11 and EXO1 nucleases in BRCA-deficient cells.
Externí odkaz:
https://doaj.org/article/fcffd21913bc45bdb2ca47c3e609a412
Autor:
Yi-Chang Wang, Andrew A. Kelso, Adak Karamafrooz, Yi-Hsuan Chen, Wei-Kai Chen, Chun-Ting Cheng, Yue Qi, Long Gu, Linda Malkas, Angelo Taglialatela, Hsing-Jien Kung, George-Lucian Moldovan, Alberto Ciccia, Jeremy M. Stark, David K. Ann
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112296- (2023)
Summary: The arginine dependency of cancer cells creates metabolic vulnerability. In this study, we examine the impact of arginine availability on DNA replication and genotoxicity resistance. Using DNA combing assays, we find that limiting extracellu
Externí odkaz:
https://doaj.org/article/02cf18b55c154e37b1ee31164012f9d4
Autor:
Emily M. Schleicher, Ashna Dhoonmoon, Lindsey M. Jackson, Jude B. Khatib, Claudia M. Nicolae, George-Lucian Moldovan
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-12 (2022)
Abstract Maintenance of replication fork stability is essential for genome preservation. Stalled replication forks can be reversed by translocases such as SMARCAL1, and unless protected through the activity of the BRCA pathway, are subsequently subje
Externí odkaz:
https://doaj.org/article/62ab80586c0647d183275c406a41f42c
Autor:
Iwona Hirschler-Laszkiewicz, Fernanda Festa, Suming Huang, George-Lucian Moldovan, Claudia Nicolae, Ashna Dhoonmoon, Lei Bao, Kerry Keefer, Shu-jen Chen, Hong-Gang Wang, Joseph Y. Cheung, Barbara A. Miller
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Transient receptor potential channel melastatin 2 (TRPM2) is highly expressed in cancer and has an essential function in preserving viability through maintenance of mitochondrial function and antioxidant response. Here, the role of TRPM2 in
Externí odkaz:
https://doaj.org/article/4fbf757ed7af457bbd255a2db843529c
Autor:
Arindam Datta, Kajal Biswas, Joshua A. Sommers, Haley Thompson, Sanket Awate, Claudia M. Nicolae, Tanay Thakar, George-Lucian Moldovan, Robert H. Shoemaker, Shyam K. Sharan, Robert M. Brosh
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
The tumor suppressor BRCA2 protects stalled DNA replication forks from unrestrained degradation; however the mechanism whereby unprotected stalled forks are preserved and restarted has remained elusive. Here the authors show that the WRN helicase pro
Externí odkaz:
https://doaj.org/article/dd9a83371d84474f8a570030b092cfce
Autor:
Kristen E. Clements, Emily M. Schleicher, Tanay Thakar, Anastasia Hale, Ashna Dhoonmoon, Nathanial J. Tolman, Anchal Sharma, Xinwen Liang, Yuka Imamura Kawasawa, Claudia M. Nicolae, Hong-Gang Wang, Subhajyoti De, George-Lucian Moldovan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Mutations in the homologous recombination proteins BRCA1 and BRCA2 can sensitize cells to treatment with inhibitors of poly-ADP-ribose polymerase 1 (PARPi), but resistance to the treatment can occur. Here the authors by genome-wide CRISPR knockout an
Externí odkaz:
https://doaj.org/article/bbee1b004cdc4bdebae2ddc9b6d5a3f3