Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Lucian Ghitescu"'
Publikováno v:
Journal of Histochemistry & Cytochemistry. 56:605-614
SUMMARY Aging and diabetes are associated with exacerbated expression of adhesion molecules. Given their importance in endothelial dysfunction and their possible involvement in the alteration of glomerular permeability occurring in diabetes, we have
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1762(1):94-102
The participation of glucose and two intermediates of glucose metabolism: glucose-6-phosphate (G6P) and glyceraldehyde-3-phosphate (Gald3P) to the formation of early glycation products was comparatively evaluated in the endothelial plasma membrane of
Autor:
Graeme K. Hunter, Dorin-Lucian Ghitescu, Micheline Fortin, Rima Wazen, Harvey A. Goldberg, Antonio Nanci, S. Zalzal
Publikováno v:
Journal of Histochemistry & Cytochemistry. 52:1591-1600
Osteopontin (OPN), a major non-collagenous matrix protein of bone, is also found in tissue fluids and in the circulation. It is still not clear whether circulating OPN contributes to bone formation. To elucidate this question, rat OPN was tagged with
Publikováno v:
Journal of Histochemistry & Cytochemistry. 52:65-76
We investigated the mechanism by which diabetes renders the capillary endothelium more permeable to macromolecules in the lungs of short-term diabetic rats. We used quantitative immunocytochemistry (ICC) to comparatively assess the permeability of al
Publikováno v:
Diabetologia. 45:1017-1025
Aims/hypothesis. We undertook the characterization of the capillary bed of the rat frontal cortex and their permeability properties in short-term and long-term diabetic rats. Methods. Diabetes was induced by strepozotocin injection. Rats were maintai
Publikováno v:
Laboratory Investigation. 80:1171-1184
The alteration induced by diabetes on vascular permeability to serum albumin was investigated in the mesentery of streptozotocin-induced hyperglycemic rats. Double-tagged ((125)I and dinitrophenol-haptenated) heterologous albumin was intravenously ad
Publikováno v:
The Journal of Cell Biology
By using an immunoisolation procedure (Stan, R.-V., W.G. Roberts, K. Ihida, D. Predescu, L. Saucan, L. Ghitescu, and G.E. Palade. 1997. Mol. Biol. Cell. 8:595–605) developed in our laboratory, we have isolated a caveolar subfraction from rat lung e
Publikováno v:
Endothelium. 6:241-250
A monoclonal antibody raised against purified rat lung endothelial plasma membranes was found to recognize an apparently novel, 85 kD, integral endothelial plasma membrane glycoprotein. By immunofluorescence and electron microscope immunocytochemistr
Publikováno v:
Biochemical Journal. 326:539-544
Luminal membranes of the vascular endothelium were isolated from brain, heart and lungs by modification of their density. The presence of P-glycoprotein (P-gp) was detected by Western blotting in luminal membranes from the endothelium of the three ti
Publikováno v:
Microscopy Research and Technique. 31:118-127
The internalization and degradation of glomerular filtered serum proteins by the proximal tubular epithelium has been extensively studied by microperfusion methods. By using a cationic probe that easily traverses the glomerular wall into the urinary