Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Lucia Sergi Sergi"'
Autor:
Claudia Asperti, Daniele Canarutto, Simona Porcellini, Francesca Sanvito, Francesca Cecere, Valentina Vavassori, Samuele Ferrari, Elisabetta Rovelli, Luisa Albano, Aurelien Jacob, Lucia Sergi Sergi, Elisa Montaldo, Francesca Ferrua, Luis Ignacio González-Granado, Vassilios Lougaris, Raffaele Badolato, Andrea Finocchi, Anna Villa, Marina Radrizzani, Luigi Naldini
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 546-557 (2023)
Hyper-IgM1 is a rare X-linked combined immunodeficiency caused by mutations in the CD40 ligand (CD40LG) gene with a median survival of 25 years, potentially treatable with in situ CD4+ T cell gene editing with Cas9 and a one-size-fits-most corrective
Externí odkaz:
https://doaj.org/article/95bf4664548f487685bff24201e74568
Autor:
Daniele Canarutto, Claudia Asperti, Valentina Vavassori, Simona Porcellini, Elisabetta Rovelli, Marianna Paulis, Samuele Ferrari, Tiziana Plati, Lucia Sergi Sergi, Anna Villa, Marina Radrizzani, Luigi Naldini
Publikováno v:
HemaSphere, Vol 7, p e6715437 (2023)
Externí odkaz:
https://doaj.org/article/bc9d4c9418754b6698f01cbb046d797d
Autor:
Monica Soldi, Lucia Sergi Sergi, Giulia Unali, Thomas Kerzel, Ivan Cuccovillo, Paola Capasso, Andrea Annoni, Mauro Biffi, Paola Maria Vittoria Rancoita, Alessio Cantore, Angelo Lombardo, Luigi Naldini, Mario Leonardo Squadrito, Anna Kajaste-Rudnitski
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 411-425 (2020)
Lentiviral vectors (LVs) are increasingly employed in gene and cell therapy. Standard laboratory production of LVs is not easily scalable, and research-grade LVs often contain contaminants that can interfere with downstream applications. Moreover, pu
Externí odkaz:
https://doaj.org/article/e9a98b4f0c0f4908aaf5513efa10181b
Autor:
Marianna Paulis, Lucia Susani, Alessandra Castelli, Teruhiko Suzuki, Takahiko Hara, Letizia Straniero, Stefano Duga, Dario Strina, Stefano Mantero, Elena Caldana, Lucia Sergi Sergi, Anna Villa, Paolo Vezzoni
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 369-377 (2020)
Many human genetic diseases are associated with gross mutations such as aneuploidies, deletions, duplications, or inversions. For these “structural” disorders, conventional gene therapy, based on viral vectors and/or on programmable nuclease-medi
Externí odkaz:
https://doaj.org/article/cafafd205a104ab4b7eb5032e65b38ea
Autor:
Ileana Bortolomai, Monica Sandri, Elena Draghici, Elena Fontana, Elisabetta Campodoni, Genni Enza Marcovecchio, Francesca Ferrua, Laura Perani, Antonello Spinelli, Tamara Canu, Marco Catucci, Tiziano Di Tomaso, Lucia Sergi Sergi, Antonio Esposito, Angelo Lombardo, Luigi Naldini, Anna Tampieri, Georg A. Hollander, Anna Villa, Marita Bosticardo
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 10, Pp 1107-1122 (2019)
Abstract Defective functionality of thymic epithelial cells (TECs), due to genetic mutations or injuring causes, results in altered T‐cell development, leading to immunodeficiency or autoimmunity. These defects cannot be corrected by hematopoietic
Externí odkaz:
https://doaj.org/article/84a5cdcf9f7d4b5e98536d3398bf01f3
Autor:
Valentina Capo, Sara Penna, Ivan Merelli, Matteo Barcella, Serena Scala, Luca Basso-Ricci, Elena Draghici, Eleonora Palagano, Erika Zonari, Giacomo Desantis, Paolo Uva, Roberto Cusano, Lucia Sergi Sergi, Laura Crisafulli, Despina Moshous, Polina Stepensky, Katarzyna Drabko, Zühre Kaya, Ekrem Unal, Alper Gezdirici, Giuseppe Menna, Marta Serafini, Alessandro Aiuti, Silvia Laura Locatelli, Carmelo Carlo-Stella, Ansgar S. Schulz, Francesca Ficara, Cristina Sobacchi, Bernhard Gentner, Anna Villa
Publikováno v:
Haematologica, Vol 106, Iss 1 (2020)
Allogeneic hematopoietic stem cell transplantation is the treatment of choice for autosomal recessive osteopetrosis caused by defects in the TCIRG1 gene. Despite recent progress in conditioning, a relevant number of patients are not eligible for allo
Externí odkaz:
https://doaj.org/article/41f41f3cd71f426da4e55083438ac158
Autor:
Rossella Galli, Pietro Luigi Poliani, Gian Giacomo Consalez, Ferdinando Rossi, Paola Rossi, Alessandro Bulfone, Lorenzo Piemonti, Letterio Salvatore Politi, Lucia Sergi Sergi, Alessandra Di Gregorio, Raffaella Melzi, Federico Brandalise, Valeria Barili, Laura Croci, Ketty Leto, Barbara Cipelletti, Manuela Cominelli, Mauro Pala, Daniela Corno
PDF file - 213K, Gene signatures distinguishing the different MB CSC populations segregate distinct human MB molecular subgroups, with MB1_EXCLUSIVE gene signature distinguishing the WNT molecular subgroup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c651599119a1de4b188924183738de36
https://doi.org/10.1158/2159-8290.22528866
https://doi.org/10.1158/2159-8290.22528866
Autor:
Rossella Galli, Pietro Luigi Poliani, Gian Giacomo Consalez, Ferdinando Rossi, Paola Rossi, Alessandro Bulfone, Lorenzo Piemonti, Letterio Salvatore Politi, Lucia Sergi Sergi, Alessandra Di Gregorio, Raffaella Melzi, Federico Brandalise, Valeria Barili, Laura Croci, Ketty Leto, Barbara Cipelletti, Manuela Cominelli, Mauro Pala, Daniela Corno
PDF file - 183K, Long term-cultured hindbrain- and forebrain-derived NSCs are Sonic Hedgehog (Shh) pathway-independent, as cyclopamine treatment negatively affects the survival/proliferation of short-term cultured but not of long term-cultured NSCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f12b716039b9cf432307922795ac91d
https://doi.org/10.1158/2159-8290.22528872.v1
https://doi.org/10.1158/2159-8290.22528872.v1
Autor:
Rossella Galli, Pietro Luigi Poliani, Gian Giacomo Consalez, Ferdinando Rossi, Paola Rossi, Alessandro Bulfone, Lorenzo Piemonti, Letterio Salvatore Politi, Lucia Sergi Sergi, Alessandra Di Gregorio, Raffaella Melzi, Federico Brandalise, Valeria Barili, Laura Croci, Ketty Leto, Barbara Cipelletti, Manuela Cominelli, Mauro Pala, Daniela Corno
PDF file - 155K, Enforced expression of Ebf3 in CB WM and SVZ NSCs results in premature neuronal differentiation, under proliferative and differentiative conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb2de0cf55dbfe24ac2822debbc93ac
https://doi.org/10.1158/2159-8290.22528857.v1
https://doi.org/10.1158/2159-8290.22528857.v1
Autor:
Rossella Galli, Pietro Luigi Poliani, Gian Giacomo Consalez, Ferdinando Rossi, Paola Rossi, Alessandro Bulfone, Lorenzo Piemonti, Letterio Salvatore Politi, Lucia Sergi Sergi, Alessandra Di Gregorio, Raffaella Melzi, Federico Brandalise, Valeria Barili, Laura Croci, Ketty Leto, Barbara Cipelletti, Manuela Cominelli, Mauro Pala, Daniela Corno
PDF file - 157K, MB CSC lines are Sonic Hedgehog (Shh) pathway-independent, as their survival/proliferation is not affected by cyclopamine treatment and Smo silencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6683790a40704fca8ae5ea3155ca85d1
https://doi.org/10.1158/2159-8290.22528869.v1
https://doi.org/10.1158/2159-8290.22528869.v1