Výsledky vyhledávání - "Lucia Rohrer"

Akademický článek

Altered Distribution of Unesterified Cholesterol among Lipoprotein Subfractions of Patients with Diabetes Mellitus Type 2

Autor: Livia Noemi Kolb, Alaa Othman, Lucia Rohrer, Jan Krützfeldt, Arnold von Eckardstein

Publikováno v: Biomolecules, Vol 13, Iss 3, p 497 (2023)

Biomarkers are important tools to improve the early detection of patients at high risk for developing diabetes as well as the stratification of diabetic patients towards risks of complications. In addition to clinical variables, we analyzed 155 metab

Externí odkaz: https://doaj.org/article/e88f6f016c5745759c62f271d1ddb3fc

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Akademický článek

HDL inhibits endoplasmic reticulum stress-induced apoptosis of pancreatic β-cells in vitro by activation of Smoothened[S]

Autor: Mustafa Yalcinkaya, Anja Kerksiek, Katrin Gebert, Wijtske Annema, Rahel Sibler, Silvija Radosavljevic, Dieter Lütjohann, Lucia Rohrer, Arnold von Eckardstein

Publikováno v: Journal of Lipid Research, Vol 61, Iss 4, Pp 492-504 (2020)

Loss of pancreatic β-cell mass and function as a result of sustained ER stress is a core step in the pathogenesis of diabetes mellitus type 2. The complex control of β-cells and insulin production involves hedgehog (Hh) signaling pathways as well a

Externí odkaz: https://doaj.org/article/5d1ba45ad54d475ca39156b754feed59

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Akademický článek

Scavenger receptor BI promotes cytoplasmic accumulation of lipoproteins in clear-cell renal cell carcinoma

Autor: Srividya Velagapudi, Peter Schraml, Mustafa Yalcinkaya, Hella A. Bolck, Lucia Rohrer, Holger Moch, Arnold von Eckardstein

Publikováno v: Journal of Lipid Research, Vol 59, Iss 11, Pp 2188-2201 (2018)

Clear-cell renal cell carcinomas (ccRCCs) are characterized by inactivation of the von Hippel-Lindau (VHL) gene and intracellular lipid accumulation by unknown pathomechanisms. The immunochemical analysis of 356 RCCs revealed high abundance of apoA-I

Externí odkaz: https://doaj.org/article/3c8ca98bf1194103a64c23f781da89b0

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Akademický článek

Cholesterol Efflux Capacity Associates with the Ankle-Brachial Index but Not All-Cause Mortality in Patients with Peripheral Artery Disease

Autor: Robert K. Clemens, Monika Hunjadi, Andreas Ritsch, Lucia Rohrer, Thomas O. Meier, Beatrice Amann-Vesti, Arnold von Eckardstein, Wijtske Annema

Publikováno v: Diagnostics, Vol 11, Iss 8, p 1407 (2021)

Background: Cholesterol efflux is an important mechanism by which high-density lipoproteins (HDLs) protect against cardiovascular disease. As peripheral artery disease (PAD) is associated with high mortality rates, mainly due to cardiovascular causes

Externí odkaz: https://doaj.org/article/5f1217a249e441b695d1c7f8c7e65419

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Akademický článek

Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration

Publikováno v: eLife, Vol 8 (2019)

Age-related macular degeneration (AMD) is a progressive disease of the retinal pigment epithelium (RPE) and the retina leading to loss of central vision. Polymorphisms in genes involved in lipid metabolism, including the ATP-binding cassette transpor

Externí odkaz: https://doaj.org/article/992b60ec1c9e471eb4c01c575ad91eb9

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Akademický článek

Inhibition of Vascular c‐Jun N‐Terminal Kinase 2 Improves Obesity‐Induced Endothelial Dysfunction After Roux‐en‐Y Gastric Bypass

Autor: Petia Doytcheva, Thomas Bächler, Erika Tarasco, Vincenzo Marzolla, Michael Engeli, Giovanni Pellegrini, Simona Stivala, Lucia Rohrer, Francesco Tona, Giovanni G. Camici, Paul M. Vanhoutte, Christian M. Matter, Thomas A. Lutz, Thomas F. Lüscher, Elena Osto

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 11 (2017)

BackgroundRoux‐en‐Y gastric bypass (RYGB) reduces obesity‐associated comorbidities and cardiovascular mortality. RYGB improves endothelial dysfunction, reducing c‐Jun N‐terminal kinase (JNK) vascular phosphorylation. JNK activation links ob

Externí odkaz: https://doaj.org/article/875b36b285cb445db7c4f362ac80ac18

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Akademický článek

Apolipoprotein M modulates erythrocyte efflux and tubular reabsorption of sphingosine-1-phosphate

Autor: Iryna Sutter, Rebekka Park, Alaa Othman, Lucia Rohrer, Thorsten Hornemann, Markus Stoffel, Olivier Devuyst, Arnold von Eckardstein

Publikováno v: Journal of Lipid Research, Vol 55, Iss 8, Pp 1730-1737 (2014)

Sphingosine-1-phosphate (S1P) mediates several cytoprotective functions of HDL. apoM acts as a S1P binding protein in HDL. Erythrocytes are the major source of S1P in plasma. After glomerular filtration, apoM is endocytosed in the proximal renal tubu

Externí odkaz: https://doaj.org/article/a0ed11efaa4a4229bd744ddc8bd98519

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Akademický článek

A three-dimensional engineered artery model for in vitro atherosclerosis research.

Autor: Jérôme Robert, Benedikt Weber, Laura Frese, Maximilian Y Emmert, Dörthe Schmidt, Arnold von Eckardstein, Lucia Rohrer, Simon P Hoerstrup

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e79821 (2013)

The pathogenesis of atherosclerosis involves dysfunctions of vascular endothelial cells and smooth muscle cells as well as blood borne inflammatory cells such as monocyte-derived macrophages. In vitro experiments towards a better understanding of the

Externí odkaz: https://doaj.org/article/532beecce7fe400fba125ef0b2a2aa49

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