Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Lucia Roa"'
Autor:
Lyanne Delgado-Coka, Michael Horowitz, Mariana Torrente-Goncalves, Lucia Roa-Peña, Cindy V. Leiton, Mahmudul Hasan, Sruthi Babu, Danielle Fassler, Jaymie Oentoro, Ji-Dong K Bai, Emanuel F. Petricoin, Lynn M. Matrisian, Edik Matthew Blais, Natalia Marchenko, Felicia D. Allard, Wei Jiang, Brent Larson, Andrew Hendifar, Chao Chen, Shahira Abousamra, Dimitris Samaras, Tahsin Kurc, Joel Saltz, Luisa F. Escobar-Hoyos, Kenneth R. Shroyer
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background The immune microenvironment impacts tumor growth, invasion, metastasis, and patient survival and may provide opportunities for therapeutic intervention in pancreatic ductal adenocarcinoma (PDAC). Although never studied as a potent
Externí odkaz:
https://doaj.org/article/d0bfc3b841b643c9bb6db994b3bb87d5
Publikováno v:
Journal of Pathology Informatics, Vol 15, Iss , Pp 100390- (2024)
Cytomorphology evaluation of bone marrow cell is the initial step to diagnose different hematological diseases. This assessment is still manually performed by trained specialists, who may be a bottleneck within the clinical process. Deep learning alg
Externí odkaz:
https://doaj.org/article/38685f3df52a4fb2a64f035d77c7d936
Autor:
Lucia Roa-Peña
Publikováno v:
Revista de la Facultad de Medicina, Vol 42, Iss 4, Pp 215-219 (1994)
Apoptosis es una forma de muerte celular programada, la cual juega un papel importante en el desarrollo y mantenimiento de los tejidos. Sus características morfológicas y bioquímicas son distintas a las de la necrosis. Estas diferencias incluyen a
Externí odkaz:
https://doaj.org/article/2d0e10b4b0244c3aa88f7601023b3520
Autor:
Kenneth R. Shroyer, David Talmage, Ali Akalin, Ramsey Al-Khalil, Erik Nielsen, Anna Banach, Nilofar Najafian, Elizabeth A. Vanner, Lucia Roa-Peña, Ruchi Shah, Luisa F. Escobar-Hoyos
Endogenous expression of K17 in cervical cancer cell lines and knockdown efficiency by siRNAs and shRNAs against K17 in SiHa and CaSki cells (S1); K17 knockdown induces cell-cycle arrest at G1 (S2); K17 knockdown induces p27KIP1 nuclear accumulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a7e7be53d376976695d75c95fc84e3
https://doi.org/10.1158/0008-5472.22407542.v1
https://doi.org/10.1158/0008-5472.22407542.v1
Autor:
Kenneth R. Shroyer, David Talmage, Ali Akalin, Ramsey Al-Khalil, Erik Nielsen, Anna Banach, Nilofar Najafian, Elizabeth A. Vanner, Lucia Roa-Peña, Ruchi Shah, Luisa F. Escobar-Hoyos
Comparison between discovery- and validation-datasets (S1); Comparison between the hazard ratio and survival probability estimated for the discovery, validation and combined datasets on K17 as a prognostic marker in squamous cell carcinomas of the ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e7f6148188330da817c5ce38a04da3
https://doi.org/10.1158/0008-5472.22407539
https://doi.org/10.1158/0008-5472.22407539
Autor:
Kenneth R. Shroyer, David Talmage, Ali Akalin, Ramsey Al-Khalil, Erik Nielsen, Anna Banach, Nilofar Najafian, Elizabeth A. Vanner, Lucia Roa-Peña, Ruchi Shah, Luisa F. Escobar-Hoyos
Video showing the proposed model: K17 promotes nuclear export and subsequent degradation of tumor-suppressor p27KIP1, promoting sustained proliferation and tumor growth.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bce88e9188f9ffb76f56521b1638a6a
https://doi.org/10.1158/0008-5472.22407536
https://doi.org/10.1158/0008-5472.22407536
Autor:
Ryan R. Kawalerski, Mariana Torrente Gonçalves, Chun-Hao Pan, Robert Tseng, Lucia Roa-Peña, Cindy V. Leiton, Luke A. Torre-Healy, Taryn Boyle, Sumedha Chowdhury, Natasha T. Snider, Kenneth R. Shroyer, Luisa F. Escobar-Hoyos
Keratin 17 (K17), an oncofetal intermediate filament protein, is one of the most abundantly expressed proteins in pancreatic ductal adenocarcinomas (PDACs) of the most aggressive molecular subtype. The mechanistic roles of this protein in malignancy,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcd6aacf53feda75660210be9a217c9b
https://doi.org/10.1101/2022.08.27.504988
https://doi.org/10.1101/2022.08.27.504988
Autor:
Chun-Hao Pan, Nina V. Chaika, Robert Tseng, Md Afjalus Siraj, Bo Chen, Katie L. Donnelly, Michael Horowitz, Cindy V. Leiton, Sumedha Chowdhury, Lucia Roa-Peña, Lyanne Oblein, Natalia Marchenko, Pankaj K. Singh, Kenneth R. Shroyer, Luisa F. Escobar-Hoyos
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer death. We previously reported keratin 17 (K17) as a novel negative prognostic and predictive biomarker, whose overexpression confers the resistance to chemotherapies. Here, we inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d002d9a6fbec605b5feca82f797c244
https://doi.org/10.1101/2022.08.24.504873
https://doi.org/10.1101/2022.08.24.504873
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::472fd910bb96d320d6cccb13d1b27570
https://doi.org/10.1096/fasebj.2022.36.s1.r2935
https://doi.org/10.1096/fasebj.2022.36.s1.r2935
Autor:
Lucia Roa-Peña, Kenneth R. Shroyer, Ji Dong K. Bai, Wei Hou, Sruthi Babu, Ali Akalin, Luisa F. Escobar-Hoyos
Publikováno v:
Human Pathology. 94:40-50
Summary Keratin 17 (K17) has been established as a negative prognostic biomarker in cervical and ovarian cancers but has not previously been evaluated as a prognostic biomarker in endometrial adenocarcinoma. The association of K17 with decreased pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df3328887150cef0c0853f518ef65dae
https://doi.org/10.1016/j.humpath.2019.09.005
https://doi.org/10.1016/j.humpath.2019.09.005