Zobrazeno 1 - 10
of 236
pro vyhledávání: '"Lucia R, Languino"'
Autor:
Katarzyna Bialkowska, Lamyae El Khalki, Priyanka S. Rana, Wei Wang, Daniel J. Lindner, Yvonne Parker, Lucia R. Languino, Dario C. Altieri, Elzbieta Pluskota, Khalid Sossey-Alaoui, Edward F. Plow
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Kindlin-2 is a cytoskeletal adapter protein that is present in many different cell types. By virtue of its interaction with multiple binding partners, Kindlin-2 intercalates into numerous signaling pathways and cytoskeletal nodes. A specific
Externí odkaz:
https://doaj.org/article/5573cad98044439ab462d68666ca541d
Autor:
Nicole M. Naranjo, Anne Kennedy, Anna Testa, Cecilia E. Verrillo, Adrian D. Altieri, Rhonda Kean, D. Craig Hooper, Jindan Yu, Jonathan Zhao, Oliver Abinader, Maxwell W. Pickles, Adam Hawkins, William K. Kelly, Ramkrishna Mitra, Lucia R. Languino
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
Prostate cancer has heterogeneous growth patterns, and its prognosis is the poorest when it progresses to a neuroendocrine phenotype. Using bioinformatic analysis, we evaluated RNA expression of neuroendocrine genes in a panel of five different cance
Externí odkaz:
https://doaj.org/article/cc3eebc16b874208b219a26ee873f2eb
Autor:
Cecilia E. Verrillo, Fabio Quaglia, Christopher D. Shields, Stephen Lin, Andrew V. Kossenkov, Hsin‐Yao Tang, David Speicher, Nicole M. Naranjo, Anna Testa, William K. Kelly, Qin Liu, Benjamin Leiby, Luca Musante, Khalid Sossey‐Alaoui, Navneet Dogra, Tzu‐Yi Chen, Dario C. Altieri, Lucia R. Languino
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 8, Pp n/a-n/a (2024)
Abstract It is known that small extracellular vesicles (sEVs) are released from cancer cells and contribute to cancer progression via crosstalk with recipient cells. We have previously reported that sEVs expressing the αVβ3 integrin, a protein upre
Externí odkaz:
https://doaj.org/article/04359d9772ad413f94e97e0367c5aad3
Autor:
Shiv Ram Krishn, Vaughn Garcia, Nicole M. Naranjo, Fabio Quaglia, Christopher D. Shields, Maisha A. Harris, Andrew V. Kossenkov, Qin Liu, Eva Corey, Dario C. Altieri, Lucia R. Languino
Publikováno v:
Cancer Biology & Therapy, Vol 23, Iss 1, Pp 173-185 (2022)
The αVβ6 integrin, an epithelial-specific cell surface receptor absent in normal prostate and expressed during prostate cancer (PrCa) progression, is a therapeutic target in many cancers. Here, we report that transcript levels of ITGB6 (encoding th
Externí odkaz:
https://doaj.org/article/72b471d60c604bb597ae18142f20f9e6
Autor:
Fabio Quaglia, Shiv Ram Krishn, Khalid Sossey-Alaoui, Priyanka Shailendra Rana, Elzbieta Pluskota, Pyung Hun Park, Christopher D. Shields, Stephen Lin, Peter McCue, Andrew V. Kossenkov, Yanqing Wang, David W. Goodrich, Sheng-Yu Ku, Himisha Beltran, William K. Kelly, Eva Corey, Maja Klose, Christine Bandtlow, Qin Liu, Dario C. Altieri, Edward F. Plow, Lucia R. Languino
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Androgen deprivation therapies aimed to target prostate cancer (PrCa) are only partially successful given the occurrence of neuroendocrine PrCa (NEPrCa), a highly aggressive and highly metastatic form of PrCa, for which there is no effective
Externí odkaz:
https://doaj.org/article/3eeb18d3b89f4f6090553922e8d4285e
Autor:
Rachel M. DeRita, Aejaz Sayeed, Vaughn Garcia, Shiv Ram Krishn, Christopher D. Shields, Srawasti Sarker, Andrea Friedman, Peter McCue, Sudheer Kumar Molugu, Ulrich Rodeck, Adam P. Dicker, Lucia R. Languino
Publikováno v:
iScience, Vol 14, Iss , Pp 199-209 (2019)
Summary: The β1 integrins, known to promote cancer progression, are abundant in extracellular vesicles (EVs). We investigated whether prostate cancer (PrCa) EVs affect anchorage-independent growth and whether β1 integrins are required for this effe
Externí odkaz:
https://doaj.org/article/0e57f5266b1746bdbc2f8cb9cf5a38f7
Autor:
Fabio Quaglia, Shiv Ram Krishn, Yanqing Wang, David W Goodrich, Peter McCue, Andrew V Kossenkov, Amy C Mandigo, Karen E Knudsen, Paul H Weinreb, Eva Corey, William K Kelly, Lucia R Languino
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0244985 (2021)
Neuroendocrine prostate cancer (NEPrCa) arises de novo or after accumulation of genomic alterations in pre-existing adenocarcinoma tumors in response to androgen deprivation therapies. We have provided evidence that small extracellular vesicles relea
Externí odkaz:
https://doaj.org/article/976a661517ad44058853982bade5a864
Autor:
Shiv Ram Krishn, Israa Salem, Fabio Quaglia, Nicole M. Naranjo, Ekta Agarwal, Qin Liu, Srawasti Sarker, Jessica Kopenhaver, Peter A. McCue, Paul H. Weinreb, Shelia M. Violette, Dario C. Altieri, Lucia R. Languino
Publikováno v:
Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)
Prostate cancer (PrCa) cells crosstalk with the tumour microenvironment by releasing small extracellular vesicles (sEVs). sEVs, as well as large extracellular vesicles (LEVs), isolated via iodixanol density gradients from PrCa cell culture media, exp
Externí odkaz:
https://doaj.org/article/bd1b27636456482fba3d34cdb9721249
Autor:
Fabio Quaglia, Shiv Ram Krishn, George G. Daaboul, Srawasti Sarker, Raffaella Pippa, Josep Domingo-Domenech, Gaurav Kumar, Paolo Fortina, Peter McCue, William K. Kelly, Himisha Beltran, Qin Liu, Lucia R. Languino
Publikováno v:
Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)
The ability of small extracellular vesicles (sEVs) to reprogram cancer cells is well established. However, the specific sEV components able to mediate aberrant effects in cancer cells have not been characterized. Integrins are major players in mediat
Externí odkaz:
https://doaj.org/article/a987d4b64c7241bcbd7735801cedadae
Autor:
Kristopher S. Raghavan, Ralph Francescone, Janusz Franco-Barraza, Jaye C. Gardiner, Débora B. Vendramini-Costa, Tiffany Luong, Narges Pourmandi, Anthony Andren, Alison Kurimchak, Charline Ogier, Paul M. Campbell, James S. Duncan, Costas A. Lyssiotis, Lucia R. Languino, Edna Cukierman
Publikováno v:
Cancer Research Communications. 2:1017-1036
It is projected that in 5 years, pancreatic cancer will become the second deadliest cancer in the United States. A unique aspect of pancreatic ductal adenocarcinoma (PDAC) is its stroma; rich in cancer-associated fibroblasts (CAFs) and a dense CAF-ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::508217e8450118bc2997da90ee3e5389
https://doi.org/10.1158/2767-9764.crc-21-0147
https://doi.org/10.1158/2767-9764.crc-21-0147