Correction to 'Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells'

Autor: Sergio Valente, Diana Borovika, Biagina Marrocco, Clemens Zwergel, Peteris Trapencieris, Ilaria Carnevale, Elisabetta Ferretti, Paolo Mellini, Giulia Stazi, Lucia Polletta, Serena Saladini, Marco Tafani, Antonello Mai

Publikováno v: Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 373(1755)

Novel pyrazole-based EZH2 inhibitors have been prepared through a molecular pruning approach from known inhibitors bearing a bicyclic moiety as a central scaffold. The hit compound 1o (N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-methyl-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc07f92006f21a1b59359e1224816fbc
https://pubmed.ncbi.nlm.nih.gov/29685965

Sirtuins and Resveratrol-Derived Compounds: A Model for Understanding the Beneficial Effects of the Mediterranean Diet

Autor: Matteo Antonio Russo, Enza Vernucci, Marco Tafani, Elena De Santis, Luigi Sansone, Lucia Polletta, Alessandra Runci, Mohammad Mamunur Rashid, Ilaria Carnevale

Publikováno v: Endocrine, Metabolic & Immune Disorders-Drug Targets. 14:300-308

The beneficial effects of the Mediterranean diet (MD) had been first observed about 50 years ago. Consumption of fresh vegetables and fruits, cereals, red wine, nuts, legumes, etc. has been regarded as the primary factor for protection from many huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d6106a31d30489757d1b019a7f85760
https://doi.org/10.2174/1871530314666140709093305

1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells

Autor: Paolo Mellini, Donatella Del Bufalo, Sébastien Moniot, Lucia Polletta, Clemens Steegborn, Marco Tafani, Ilaria Carnevale, Roberta Budriesi, Maria Tardugno, Lucia Altucci, Chiara Gabellini, Sandra Atlante, Daniela Trisciuoglio, Antonello Mai, Vincenzo Carafa, Angela Nebbioso, Serena Saladini, Sergio Valente, Francesco Spallotta, Clemens Zwergel, Chiara Cencioni, Carlo Gaetano

Publikováno v: Journal of medicinal chemistry (2016).
info:cnr-pdr/source/autori:Valente S, Mellini P, Spallotta F, Carafa V, Nebbioso A, Polletta L, Carnevale I, Saladini S, Trisciuoglio D, Gabellini C, Tardugno M, Zwergel C, Cencioni C, Atlante S, Moniot S, Steegborn C, Budriesi R, Tafani M, Del Bufalo D, Altucci L, Gaetano C, Mai A./titolo:1,4-Dihydropyridines Active on the SIRT1%2FAMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells./doi:/rivista:Journal of medicinal chemistry/anno:2016/pagina_da:/pagina_a:/intervallo_pagine:/volume

Modulators of sirtuins are considered promising therapeutic targets for the treatment of cancer, cardiovascular, metabolic, inflammatory, and neurodegenerative diseases. Here we prepared new 1,4-dihydropyridines (DHPs) bearing changes at the C2/C6, C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4bbdf098839e19177d1bd2f68f8889
http://hdl.handle.net/11573/870523

Muscle LIM protein/CSRP3: a mechanosensor with a role in autophagy

Autor: Matteo Antonio Russo, Eleonora Foglio, Emanuela Morgante, Ilaria Carnevale, Marco Tafani, Lucia Polletta, Tania Arcangeli, Mohammad Mamunur Rashid, Luigi Sansone, Alessandra Runci

Publikováno v: Cell Death Discovery

Muscle LIM protein (MLP) is a microtubule-associated protein expressed in cardiac and muscle tissues that belongs to the cysteine-rich protein (CSRP/CRP) family. MLP has a central role during muscle development and for architectural maintenance of mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc26610f34a641443b2113a1519fc79
https://pubmed.ncbi.nlm.nih.gov/27551448

Macrolide antibiotics exert antileukemic effects by modulating the autophagic flux through inhibition of hERG1 potassium channels

Autor: Marika Masselli, Lucia Polletta, Andrea Becchetti, Giuseppe Basso, Marinella Veltroni, Luca Gasparoli, Claudio Favre, Massimo D'Amico, Annarosa Arcangeli, Serena Pillozzi

Publikováno v: Blood Cancer Journal

Macrolide antibiotics exert antileukemic effects by modulating the autophagic flux through inhibition of hERG1 potassium channels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8373911df0b78e203360c294c067c7
https://doi.org/10.1038/bcj.2016.32