Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Lucia Pastorino"'
Autor:
Martin Balastik, Xiao Zhen Zhou, Meritxell Alberich-Jorda, Romana Weissova, Jakub Žiak, Maria F. Pazyra-Murphy, Katharina E. Cosker, Olga Machonova, Iryna Kozmikova, Chun-Hau Chen, Lucia Pastorino, John M. Asara, Adam Cole, Calum Sutherland, Rosalind A. Segal, Kun Ping Lu
Publikováno v:
Cell Reports, Vol 13, Iss 4, Pp 812-828 (2015)
Axon guidance relies on precise translation of extracellular signal gradients into local changes in cytoskeletal dynamics, but the molecular mechanisms regulating dose-dependent responses of growth cones are still poorly understood. Here, we show tha
Externí odkaz:
https://doaj.org/article/59143a7db6614643bea7b694861dcc5e
Autor:
Lucia Pastorino, Kun Ping Lu, Cindy W. C. Tam, Jane A. Driver, Suk Ling Ma, Victor W. C. Lui, Helen F.K. Chiu, Nelson L.S. Tang, Linda C. W. Lam
Publikováno v:
Neurobiology of Aging. 33:804-813
Alzheimer's disease (AD), the most common form of dementia, is characterized by the presence of neurofibrillary tangles composed of tau and senile plaques of amyloid-beta peptides (Aβ) derived from amyloid precursor protein (APP). Pin1 is a unique p
Publikováno v:
Journal of Biological Chemistry. 287:6969-6973
Alzheimer disease (AD) is characterized by the presence of senile plaques of amyloid-β (Aβ) peptides derived from amyloid precursor protein (APP) and neurofibrillary tangles made of hyperphosphorylated Tau. Increasing APP gene dosage or expression
Autor:
Christina Y. Soohoo, Tae Ho Lee, Martin Balastik, Lucia Pastorino, Greg Finn, Gerburg M. Wulf, Xiao Zhen Zhou, Kun Ping Lu, Adrian Tun-Kyi, Jormay Lim, Rong Shi
Publikováno v:
Nature Cell Biology. 11:97-105
The prolyl isomerase Pin1 acts in various cellular processes. It has now been implicated in telomere maintenance by regulating the stability of the telomere binding protein TRF1. Telomeres are essential for maintaining cellular proliferative capacity
Autor:
Kun Ping Lu, Lucia Pastorino
Publikováno v:
European Journal of Pharmacology. 545:29-38
Alzheimer's disease is a progressive neurodegenerative disorder associated with aging and characterized by neurofibrillary tangles and amyloid plaques that deposit in the brain, triggering the neurodegenerative phenomena and leading to neuronal death
Autor:
Kun Ping Lu, Lucia Pastorino
Publikováno v:
Neuroscience Research Communications. 35:213-231
This review discusses the phosphorylation of the Amyloid Precursor Protein (APP) and the possible role of this phosphorylation in Alzheimer's disease (AD). AD is a neurodegenerative disorder characterized by the deposition of β-amyloid plaques in th
Autor:
Michael A. N. Edgar, Lucia Pastorino, Linda A. Dokas, Pierre N. E. De Graan, Piera Pasinelli, Flaminio Cattabeni, Monica DiLuca, Willem Hendrik Gispen, Brian P. Anton, M. DeWit
Publikováno v:
Scopus-Elsevier
Journal of neurochemistry, 69, 2206. Raven Press
Journal of neurochemistry, 69, 2206. Raven Press
Growth-associated phosphoprotein B-50 is a neural protein kinase C (PKC) substrate enriched in nerve growth cones that has been implicated in growth cone plasticity. Here we investigated whether B-50 is a physiological substrate for casein kinase II
Autor:
Lucia Pastorino, Paola Corsini, Alessandro Padovani, Francesca Colciaghi, Barbara Borroni, Flaminio Cattabeni, Silvana Archetti, Monica Di Luca
Publikováno v:
European Neuropsychopharmacology. 12:195-200
Three major amyloid precursor protein (APP) forms with apparent molecular weight ranging from 106 to 130 kDa are present in human platelets. Alzheimer disease (AD) is associated with a decreased APP forms ratio (APPr) between the three major forms. A
Publikováno v:
Molecular and Cellular Neuroscience. 19:175-185
BACE (beta-site APP cleaving enzyme) has been recently proposed as the major aspartyl protease displaying β secretase activity in neurons. The C-terminal domain of BACE contains a dileucine motif (LL499/500) that can potentially regulate its traffic
Autor:
Francesca Colciaghi, F. Cattabeni, Serenella Albani-Torregrossa, Domenico E. Pellegrini-Giampietro, P.N.E. de Graan, M. Di Luca, Fabrizio Gardoni, Lucia Pastorino, Flavio Moroni
Publikováno v:
European Journal of Neuroscience. 12:1310-1318
We have tested whether different agonists of metabotropic glutamate receptors could induce translocation of selective protein kinase C isozymes in nerve terminals. In rat cortical synaptosomes 1S, 3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-A