Coordinated signals from PARP-1 and PARP-2 are required to establish a proper T cell immune response to breast tumors in mice

Autor: Juan Martín-Caballero, María Vernet-Tomas, José Yélamos, Carlos Martinez, Jaime Jimeno, Ivonne Vazquez, Miguel Galindo-Campos, Miguel Quintela-Fandino, Coral Ampurdanés, Nura Lutfi, Syed O. Ali, Lucia Moreno-Lama, Laura Comerma, Françoise Dantzer

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2020, 39 (13), pp.2835-2843. ⟨10.1038/s41388-020-1175-x⟩

Poly(ADP-ribose)-polymerase (PARP)-1 and PARP-2 play an essential role in the DNA damage response. Based on this effect of PARP in the tumor cell itself, PARP inhibitors have emerged as new therapeutic tools both approved and in clinical trials. Howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c624bfdc694c8d05c218d59fc74ddfc4
https://hal.archives-ouvertes.fr/hal-03005259

Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function

Autor: Jordi Farrés, Andrea Cerutti, Coral Ampurdanés, Chloé Lescale, Carlos Martinez, Lucia Moreno-Lama, Ludovic Deriano, Juan Martín-Caballero, Marie Bedora-Faure, José Yélamos, Pedro Aparicio, Françoise Dantzer, Miguel Galindo-Campos

Publikováno v: Cell Death and Differentiation
Cell Death and Differentiation, Nature Publishing Group, 2019, 26 (12), pp.2667-2681. ⟨10.1038/s41418-019-0326-5⟩
Cell death and differentiation
Cell Death and Differentiation, 2019, 26 (12), pp.2667-2681. ⟨10.1038/s41418-019-0326-5⟩

International audience; Poly (ADP-ribose) polymerase (PARP)-1 and PARP-2 regulate the function of various DNA-interacting proteins by transferring ADP-ribose emerging from catalytic cleavage of cellular β-NAD+. Hence, mice lacking PARP-1 or PARP-2 s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9654da0bf412459dff7a64223b28e580
https://hal.archives-ouvertes.fr/hal-03040994