Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Lucia Kuhn-Nentwig"'
Complex precursor structures of cytolytic cupiennins identified in spider venom gland transcriptomes
Autor:
Lucia Kuhn-Nentwig
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Analysis of spider venom gland transcriptomes focuses on the identification of possible neurotoxins, proteins and enzymes. Here, the first comprehensive transcriptome analysis of cupiennins, small linear cationic peptides, also known as cyto
Externí odkaz:
https://doaj.org/article/ff4889b0b2a346b69b04099546cded41
Autor:
Lucia Kuhn-Nentwig, Heidi E. L. Lischer, Stano Pekár, Nicolas Langenegger, Maria J. Albo, Marco Isaia, Wolfgang Nentwig
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
In the venom of spiders, linear peptides (LPs), also called cytolytical or antimicrobial peptides, represent a largely neglected group of mostly membrane active substances that contribute in some spider species considerably to the killing power of sp
Externí odkaz:
https://doaj.org/article/05050bdbd0f849b3aa9775f095672ae2
Autor:
Benjamin Clémençon, Lucia Kuhn-Nentwig, Nicolas Langenegger, Lukas Kopp, Steve Peigneur, Jan Tytgat, Wolfgang Nentwig, Benjamin P. Lüscher
Publikováno v:
Toxins, Vol 12, Iss 4, p 250 (2020)
The venom of Cupiennius salei is composed of dozens of neurotoxins, with most of them supposed to act on ion channels. Some insecticidal monomeric neurotoxins contain an α-helical part besides their inhibitor cystine knot (ICK) motif (type 1). Other
Externí odkaz:
https://doaj.org/article/8b544fd096b843edbd3c5c4d255d34d8
Autor:
Vera Oldrati, Dominique Koua, Pierre-Marie Allard, Nicolas Hulo, Miriam Arrell, Wolfgang Nentwig, Frédérique Lisacek, Jean-Luc Wolfender, Lucia Kuhn-Nentwig, Reto Stöcklin
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172966 (2017)
Venom based research is exploited to find novel candidates for the development of innovative pharmacological tools, drug candidates and new ingredients for cosmetic and agrochemical industries. Moreover, venomics, as a well-established approach in sy
Externí odkaz:
https://doaj.org/article/5c4cd6e3b33c4a27b1089d3841696fe9
Publikováno v:
Toxins, Vol 11, Iss 10, p 611 (2019)
This review gives an overview on the development of research on spider venoms with a focus on structure and function of venom components and techniques of analysis. Major venom component groups are small molecular mass compounds, antimicrobial (also
Externí odkaz:
https://doaj.org/article/a5b648127fc244079918dc400b3252c7
Publikováno v:
Toxins, Vol 11, Iss 3, p 167 (2019)
Most knowledge of spider venom concerns neurotoxins acting on ion channels, whereas proteins and their significance for the envenomation process are neglected. The here presented comprehensive analysis of the venom gland transcriptome and proteome of
Externí odkaz:
https://doaj.org/article/3c7f9029b8ee49d1a71b6de7a5052ecc
Autor:
Olivier Biner, Christian Trachsel, Aline Moser, Lukas Kopp, Nicolas Langenegger, Urs Kämpfer, Christoph von Ballmoos, Wolfgang Nentwig, Stefan Schürch, Johann Schaller, Lucia Kuhn-Nentwig
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143963 (2015)
Hyaluronidases are important venom components acting as spreading factor of toxic compounds. In several studies this spreading effect was tested on vertebrate tissue. However, data about the spreading activity on invertebrates, the main prey organism
Externí odkaz:
https://doaj.org/article/c066687fe40c40b78f45fe856624e9e9
Autor:
Dominique Koua, Lucia Kuhn-Nentwig
Publikováno v:
Toxins, Vol 9, Iss 8, p 245 (2017)
Spider venoms are rich cocktails of bioactive peptides, proteins, and enzymes that are being intensively investigated over the years. In order to provide a better comprehension of that richness, we propose a three-level family classification system f
Externí odkaz:
https://doaj.org/article/1c12d640e347420c8d05988a055fb1b9
Publikováno v:
CHIMIA, Vol 61, Iss 9 (2007)
Externí odkaz:
https://doaj.org/article/33b464e262134d3d8fa05e7209e64e8b
Autor:
Johann Schaller, Lucia Kuhn-Nentwig, Stefan Schürch, Urs Kämpfer, Jürg Mülier, Wolfgang Nentwig
Publikováno v:
CHIMIA, Vol 55, Iss 12 (2001)
Beside other components, spider venom contains neurotoxically acting peptides which predominantly target a variety of different ion channels within the spider's prey. From the multicomponent venom of Cupiennius salei 13 toxic peptides (CSTX-1 – CST
Externí odkaz:
https://doaj.org/article/aa4605652e39422dbc3ca54221a5deb6