Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lucia Kubovcakova"'
Autor:
Margaux Sevin, Lucia Kubovcakova, Nicolas Pernet, Sébastien Causse, Franck Vitte, Jean Luc Villeval, Catherine Lacout, Marine Cordonnier, Fernando Rodrigues-Lima, Gaétan Chanteloup, Matthieu Mosca, Marie-Lorraine Chrétien, Jean Noël Bastie, Sylvain Audia, Paul Sagot, Selim Ramla, Laurent Martin, Martin Gleave, Valérie Mezger, Radek Skoda, Isabelle Plo, Carmen Garrido, François Girodon, Aurélie de Thonel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Myelofibrosis is a chronic degenerative disorder characterized by progressive bone marrow fibrosis. Here, the authors show that the chaperone HSP27 contributes to myelofibrosis via regulation of the JAK2/STAT5 pathway, and that antisense oligonucleot
Externí odkaz:
https://doaj.org/article/7cd28d8985ce47f7a61f528b7a0f931b
Autor:
Jan Stetka, Marc Usart, Lucia Kubovcakova, Shivam Rai, Tata Nageswara Rao, Joshua Sutter, Hui Hao-Shen, Stefan Dirnhofer, Florian Geier, Michael Stephan Bader, Jakob R Passweg, Vania Manolova, Franz Dürrenberger, Nouraiz Ahmed, Timm Schroeder, Tomas Ganz, Elizabeta Nemeth, Laura Silvestri, Antonella Nai, Clara Camaschella, Radek C. Skoda
Publikováno v:
Blood.
JAK2-V617F mutation causes myeloproliferative neoplasms (MPN) that can manifest as polycythemia vera (PV), essential thrombocythemia (ET) or primary myelofibrosis (PMF). PV patients at diagnosis already exhibited iron deficiency, whereas ET patients
Autor:
Jan Stetka, Nouraiz Ahmed, Christian Beisel, Damien Luque Paz, Nils Hansen, Julian Hilfiker, Dominik Wolf, Steffen Koschmieder, Florian Geier, Hui Hao-Shen, Milena Kalmer, Stefan Dirnhofer, Tim H. Brümmendorf, Tata Nageswara Rao, Lucia Kubovcakova, Timm Schroeder, Max Endele, Margareta Rybarikova, Radek C. Skoda
Publikováno v:
Blood
Blood, 137 (16)
Blood, 137 (16)
We studied a subset of hematopoietic stem cells (HSCs) that are defined by elevated expression of CD41 (CD41hi) and showed bias for differentiation toward megakaryocytes (Mks). Mouse models of myeloproliferative neoplasms (MPNs) expressing JAK2-V617F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622010d9de59c7bbdfe5a74c85004689
https://europepmc.org/articles/PMC8103999/
https://europepmc.org/articles/PMC8103999/
Publikováno v:
Blood. 136:8-9
Myeloproliferative neoplasms (MPNs) are clonal hematological malignancies, which are initiated and maintained by a pool of malignant long-term hematopoietic stem cells (LT-HSCs). A recurrent gain-of-function mutation in JAK2-V617F (VF) is present in
Autor:
Isabelle Plo, Marine Cordonnier, Martin E. Gleave, Lucia Kubovcakova, Aurélie de Thonel, Selim Ramla, Jean Noel Bastie, Paul Sagot, François Girodon, Valérie Mezger, Jean-Luc Villeval, Marie-Lorraine Chretien, Franck Vitte, Laurent Martin, Matthieu Mosca, Fernando Rodrigues-Lima, Margaux Sevin, Sylvain Audia, Gaëtan Chanteloup, Nicolas Pernet, Carmen Garrido, Radek C. Skoda, Catherine Lacout, Sebastien Causse
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.1431. ⟨10.1038/s41467-018-03627-9⟩
Nature Communications, 2018, 9 (1), pp.1431. ⟨10.1038/s41467-018-03627-9⟩
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications, Nature Publishing Group, 2018, 9 (1), ⟨10.1038/s41467-018-03627-9⟩
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.1431. ⟨10.1038/s41467-018-03627-9⟩
Nature Communications, 2018, 9 (1), pp.1431. ⟨10.1038/s41467-018-03627-9⟩
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications, Nature Publishing Group, 2018, 9 (1), ⟨10.1038/s41467-018-03627-9⟩
Heat shock protein 27 (HSP27/HSPB1) is a stress-inducible chaperone that facilitates cancer development by its proliferative and anti-apoptotic functions. The OGX-427 antisense oligonucleotide against HSP27 has been reported to be beneficial against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b995f8e0680aca1f2604f10d8e27a48
https://hal.archives-ouvertes.fr/hal-02929931
https://hal.archives-ouvertes.fr/hal-02929931
Autor:
Ronny Nienhold, Florian Geier, Jakub Zmajkovic, Sara C. Meyer, Paola Guglielmelli, Radek C. Skoda, Stuart H. Orkin, Stephan Dirnhofer, Jelena D. Milosevic Feenstra, Hui Hao-Shen, Robert Kralovics, Takafumi Shimizu, Lucia Kubovcakova, Alessandro M. Vannucchi
Publikováno v:
The Journal of Experimental Medicine
The Journal of experimental medicine
The Journal of experimental medicine
Skoda et al. provide new insights into the collaboration between epigenetic regulator Ezh2 and a key hematopoietic tyrosine kinase in disease initiation and progression.
Myeloproliferative neoplasm (MPN) patients frequently show co-occurrence of
Myeloproliferative neoplasm (MPN) patients frequently show co-occurrence of
Autor:
Martin Kirschner, Josef T. Prchal, Bac Viet Le, Tomasz Skorski, Katherine J. Sullivan, Mariusz A. Wasik, Martyna Solecka, Elizaveta A. Belyaeva, Steffen Koschmieder, Lucia Kubovcakova, Yashodhara Dasgupta, Alison R. Moliterno, Radek C. Skoda, Sylwia Flis, Morgan Nawrocki, Margaret Nieborowska-Skorska, Katarzyna Piwocka, Tony Green, Huaqing Zhao, Silvia Maifrede
Publikováno v:
Blood
Myeloproliferative neoplasms (MPNs) often carry JAK2(V617F), MPL(W515L), or CALR(del52) mutations. Current treatment options for MPNs include cytoreduction by hydroxyurea and JAK1/2 inhibition by ruxolitinib, both of which are not curative. We show h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a1b2a2ee9375f7340cda1477ef02e5
https://www.repository.cam.ac.uk/handle/1810/276411
https://www.repository.cam.ac.uk/handle/1810/276411
Autor:
Catherine Ravanat, Cécile V. Denis, Catherine Strassel, François Lanza, Pierre Mangin, Monique Freund, Lucia Kubovcakova, Arnaud Dupuis, Christian Gachet, Radek C. Skoda, Raoul Herbrecht
Publikováno v:
Thrombosis and Haemostasis. 113:414-425
SummaryWe studied haemostasis in two mouse models with thrombocytosis caused by different pathogenic mechanisms. In one strain (Yall;Mpl-/-) thrombocytosis is driven by a misbalance between thrombopoietin and its receptor, whereas in the other strain
Autor:
Takafumi Shimizu, Lucia Kubovcakova, Adrian Duek, Jean Grisouard, Radek C. Skoda, Stephan Dirnhofer, Hui Hao-Shen
Publikováno v:
Blood
The acquired somatic JAK2-V617F mutation is present in >80% of patients with myeloproliferative neoplasms (MPNs). Stat3 plays a role in hematopoietic homeostasis and might influence the JAK2-V617F-driven MPN phenotype. We crossed our transgenic SclCr
Autor:
Stephan Dirnhofer, Lucia Kubovcakova, Hui Hao-Shen, Takafumi Shimizu, Jean Grisouard, Axel Karow, Pontus Lundberg, Adrian Duek, Radek C. Skoda
Publikováno v:
Blood
The interferon-γ (IFNγ)/signal transducer and activator of transcription 1 (Stat1) pathway shows higher activity in patients with essential thrombocythemia (ET) than in polycythemia vera (PV) and was proposed to be promoting the ET phenotype. We ex