Výsledky vyhledávání - "Lucia Janicova"

1046 Targeting novel pathways in chronically activated T Cells prevents functional exhaustion

Autor: Justyna Rzepecka, Andrew Hall, Mark Barbour, Emma Mallon, Marija Bedaj, Lucia Janicova, Xabier Cortes-Lavaud, Frances Acklam, Joanne Hay, Hayley Gooding, Darryl Turner, Preeti Singh, Aaron Crawford

Publikováno v: Regular and Young Investigator Award Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adf80eb2e5284626d32c18fe0103212b
https://doi.org/10.1136/jitc-2022-sitc2022.1046

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Abstract 3877: MPL-5821, a macrophage targeted ESMTM p38 MAPK inhibitor, inhibits the production of TLR agonist induced IL-10 whilst sparing T-cell functionality

Autor: Doris Clare Louise, Stephen M. Anderton, Tanja D. de Gruijl, Justyna Rzepecka, A. Marijne Heeren, Darryl G. Turner, Gary Newton, Lucia Janicova, Kathryn Chapman, David Festus Charles Moffat, Anastasia Nika, Claire Tebbutt, Martin J. Perry

Publikováno v: Cancer Research. 78:3877-3877

Compensatory release of immunosuppressive cytokines, such as IL-10, by macrophages present in the tumor microenvironment has been implicated as a mechanism for adaptive resistance to a number of immunotherapies. Our drug discovery effort utilises Est

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8be6d99158a8a71fa63eaef4e856ae46
https://doi.org/10.1158/1538-7445.am2018-3877

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Abstract 3808: Interrogation and modulation of the immunosuppressive activity of human TAM-like macrophages using in vitro cultures

Autor: Stephen M. Anderton, Lauren A. Patience, Andrew M. Hall, Laura E. Gallagher, Lucia Janicova

Publikováno v: Cancer Research. 78:3808-3808

Tumor Associated Macrophages (TAMs), characteristic of an M2-like immune-suppressive phenotype, can induce proliferation and survival of tumor cells, facilitate angiogenesis, and suppress anti-tumor immune responses via expression of co-inhibitory mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a91065d0b0d6ab2da0c521e713eae7f7
https://doi.org/10.1158/1538-7445.am2018-3808

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Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

Autor: Abedawn I. Khalaf, Judith K. Huggan, Colin J. Suckling, Ivonne Siebeke, Margaret M. Harnett, Lamyaa Al-Riyami, Michelle L. Coates, Moninder Saggar, Hwee Kee Tay, Justyna Rzepecka, William Harnett, Lucia Janicova, Jennifer C. Coltherd

Publikováno v: International Journal for Parasitology

Highlights • Small molecule analogues of the helminth immunomodulator ES-62 have been produced. • Two analogues inhibit mast cell functions and prevent airway hypersensitivity. • The analogues are drug-like and could be considered for treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298fdaf52a88fb4a1d3ede3e825b0104
https://eprints.gla.ac.uk/96825/1/96825.pdf

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