Výsledky vyhledávání - "Lucia Gargiulo"

Glycosylphosphatidylinositol-specific T cells, IFN-γ-producing T cells, and pathogenesis of idiopathic aplastic anemia

Autor: Rie Ohumi, Lucia Gargiulo, Rosario Notaro, Yoshitaka Zaimoku, Shinji Nakao, Lucio Luzzatto, Hiroyuki Maruyama, Barbara Scappini

Publikováno v: Blood. 129:388-392

To the editor: In idiopathic aplastic anemia (IAA), bone marrow failure (BMF) is caused by depletion of hematopoietic stem cells (HSCs), thought to result from a T-cell-mediated autoimmune process.[1][1] Paroxysmal nocturnal hemoglobinuria (PNH) is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd77d27cfa7b4b0e2782b28f30b7f1d6
https://doi.org/10.1182/blood-2016-09-740845

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Glycosylphosphatidylinositol-specific, CD1d-restricted T cells in paroxysmal nocturnal hemoglobinuria

Autor: Cristina Nativi, Anastasios Karadimitris, Mark Layton, Maria Papaioannou, Lucia Gargiulo, Josu de la Fuente, Aristeidis Chaidos, Giulia Talini, Lucio Luzzatto, Barbara Richichi, Rosario Notaro, Irene Roberts, Andrei V. Nikolaev, Michela Sica

Publikováno v: Blood. 121:2753-2761

The mechanism of bone marrow failure (BMF) in paroxysmal nocturnal hemoglobinuria (PNH) is not yet known. Because in PNH the biosynthesis of the glycolipid molecule glycosylphosphatidylinositol (GPI) is disrupted in hematopoietic stem and progenitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02f2f937c1ae4348130e45b4ccefcf7
https://doi.org/10.1182/blood-2012-11-469353

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Killer immunoglobulin-like receptors (KIR) and their HLA-ligands in Italian paroxysmal nocturnal haemoglobinuria (PNH) patients

Autor: Fiorella Alfinito, E. Cosentini, Umberto Giani, Lucia Gargiulo, Antonio M. Risitano, Rosario Notaro, P. Bruno, Rosa Camerlingo, V. Luongo, Michela Sica, Sonia Lastraioli, Martina Serra, Giuseppina Ruggiero, Carmine Garzillo, Giuseppe Terrazzano

Publikováno v: Tissue Antigens. 80:322-327

Paroxysmal nocturnal haemoglobinuria (PNH) is a haematopoietic disorder characterized by expansion of phosphatidylinositol glycan-A-defective progenitor(s). Immune-dependent mechanisms, likely involving a deranged T cell-dependent autoimmune response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f69ffcebd0334f09b831dacdceb7c9f
https://doi.org/10.1111/j.1399-0039.2012.01932.x

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Paroxysmal nocturnal hemoglobinuria: Significant association with specific HLA-A, -B, -C, and -DR alleles in an Italian population

Autor: Lucio Luzzatto, E. Cosentini, Daniela Aufiero, Alessandro Poggi, Rosa Camerlingo, Antonio M. Risitano, Giuseppe Pirozzi, Michela Sica, Giuseppina Ruggiero, Bruno Rotoli, M.L. Lombardi, Giuseppe Terrazzano, Fiorella Alfinito, Rosario Notaro, Lucia Gargiulo

Publikováno v: Human Immunology. 69:202-206

Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by the expansion of a P/G-A mutated hematopoietic stem cell. An immune-mediated origin has been suggested for this disease. Because HLA genes represent a susceptibility factor for autoimmunit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa5ab8cbbf222c6e77a3d5185f05eea
https://doi.org/10.1016/j.humimm.2008.02.001

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Highly homologous T-cell receptor beta sequences support a common target for autoreactive T cells in most patients with paroxysmal nocturnal hemoglobinuria

Autor: Martina Serra, Giannamaria Cerruti, Simona Zupo, Fabrizio Loiacono, Lucia Gargiulo, Lucio Luzzatto, Rosario Notaro, Sonia Lastraioli

Publikováno v: Blood. 109:5036-5042

Deficiency of glycosylphosphatidylinositol (GPI)–anchored molecules on blood cells accounts for most features of paroxysmal nocturnal hemoglobinuria (PNH) but not for the expansion of PNH (GPI−) clone(s). A plausible model is that PNH clones expa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a8e4a786c3e098f4a557d277a668dd
https://doi.org/10.1182/blood-2006-10-052381

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A Quantitative Measurement of the Human Somatic Mutation Rate

Autor: Howard T. Thaler, David J. Araten, Lucio Luzzatto, David W. Golde, Lucia Gargiulo, Rosario Notaro, Rong H. Zhang

Publikováno v: Cancer Research. 65:8111-8117

The mutation rate (μ) is a key biological feature of somatic cells that determines risk for malignant transformation, and it has been exceedingly difficult to measure in human cells. For this purpose, a potential sentinel is the X-linked PIG-A gene,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0159e0bf12b85b91c44d7b1b1a484e25
https://doi.org/10.1158/0008-5472.can-04-1198

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Killer immunoglobulin-like receptors (KIR) and their HLA-ligands in Italian paroxysmal nocturnal haemoglobinuria (PNH) patients

Autor: COSENTINI, ELENA, RISITANO, ANTONIO MARIA, GARZILLO, CARMINE, GIANI, UMBERTO, ALFINITO, FIORELLA, RUGGIERO, GIUSEPPINA, Lucia Gargiulo, Paolo Bruno, Sonia Lastraioli, Rosalba Camerlingo, Vincenza Luongo, Martina Serrab, Michela Sica, Rosario Notaro, Giuseppe Terrazzano

Publikováno v: Tissue antigens. 80(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f7d3ca15f81a065cfeaa6b3bc50bdbcc
https://pubmed.ncbi.nlm.nih.gov/22803950

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Complement Activation in Paroxysmal Nocturnal Hemoglobinuria (PNH) Causes Oxidative Damage Which May Affect Response to Eculizumab

Autor: Maria De Angioletti, Lucia Gargiulo, Giovanni Caocci, Annamaria Pellecchia, Tolulase A Olutogun, Rosario Notaro, Margherita Berardi, Giorgio La Nasa, Lucio Luzzatto, Michela Sica

Publikováno v: Blood 124 (2014).
info:cnr-pdr/source/autori:Sica, Michela; Pellecchia, Annamaria; Berardi, Margherita; Gargiulo, Lucia; Olutogun, Tolulase A.; Caocci, Giovanni; La Nasa, Giorgio; De Angioletti, Maria; Luzzatto, Lucio; Notaro, Rosario/titolo:Complement Activation in Paroxysmal Nocturnal Hemoglobinuria (PNH) Causes Oxidative Damage Which May Affect Response to Eculizumab/doi:/rivista:Blood/anno:2014/pagina_da:/pagina_a:/intervallo_pagine:/volume:124

PNH is a rare acquired clonal disorder of the hematopoietic stem cell, characterized by a somatic mutation that inactivates the X-linked PIGA gene: this in turn results in deficiency on the cell surface of all proteins anchored by the glycosylphospha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09723b610fb8f30d145c31653a8101c7
http://www.cnr.it/prodotto/i/428374

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Auto-Reactive Glycosyl-Phosphatidyl-Inositol (GPI) Specific T Cells Are Present in Most Patients with Idiopathic Aplastic Anemia (IAA)

Autor: Lucio Luzzatto, Yoshitaka Zaimoku, Hiroyuki Maruyama, Lucia Gargiulo, Rie Ohumi, Barbara Scappini, Rosario Notaro, Shinji Nakao

Publikováno v: Blood. 126:2409-2409

Idiopathic aplastic anemia (IAA) is an acquired bone marrow disease probably caused by an auto-immune attack against hematopoietic stem cells (HSCs), which leads to bone marrow failure. Many abnormalities have been observed in the T cell compartment,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab31ff50cfb0c0837289422e90e25116
https://doi.org/10.1182/blood.v126.23.2409.2409

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An urokinase receptor antagonist that inhibits cell migration by blocking the formyl peptide receptor

Autor: Katia Bifulco, Mario De Rosa, Lucia Gargiulo, Maria Patrizia Stoppelli, Maria Vincenza Carriero, Immacolata Longanesi-Cattani, Ornella Maglio, Vincenzo Pavone, Mauro Cataldi

Publikováno v: FEBS letters
582 (2008): 1141–1146. doi:10.1016/j.febslet.2008.03.001
info:cnr-pdr/source/autori:Katia Bifulco; Immacolata Longanesi-Cattani; Lucia Gargiulo; Ornella Maglio; Mauro Cataldi; Mario De Rosa; Maria Patrizia Stoppelli; Vincenzo Pavone; Maria Vincenza Carriero/titolo:An urokinase receptor antagonist that inhibits cell migration by blocking the formyl peptide receptor/doi:10.1016%2Fj.febslet.2008.03.001/rivista:FEBS letters (Print)/anno:2008/pagina_da:1141/pagina_a:1146/intervallo_pagine:1141–1146/volume:582
582(7 (2008): 1141–1146.
info:cnr-pdr/source/autori:Bifulco K, Longanesi-Cattani I, Gargiulo L, Maglio O, Cataldi M, De Rosa M, Stoppelli MP, Pavone V, Carriero MV/titolo:An urokinase receptor antagonist that inhibits cell migration by blocking the formyl peptide receptor/doi:/rivista:FEBS letters (Print)/anno:2008/pagina_da:1141/pagina_a:1146/intervallo_pagine:1141–1146/volume:582(7
info:cnr-pdr/source/autori:Bifulco K.; Longanesi-Cattani I.; Gargiulo L.; Maglio O.; De Rosa M.; Stoppelli M.P.; Pavone V.; Carriero M.V./titolo:An Urokinase Receptor Antagonist That Inhibits Cell Migration By Blocking The Formyl Peptide Receptor/doi:10.1016%2Fj.febslet.2008.03.001/rivista:FEBS letters (Print)/anno:2008/pagina_da:1141/pagina_a:1146/intervallo_pagine:1141–1146/volume:582

Urokinase receptor (uPAR) plays a key role in physiological and pathological processes sustained by an altered cell migration. We have developed peptides carrying amino acid substitutions along the Ser 88 -Arg-Ser-Arg-Tyr 92 (SRSRY) uPAR chemotactic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6064e80d2a0ac256c159505a1e8a9648
http://www.cnr.it/prodotto/i/178677

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