Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

Autor: Laetitia Baud, Mark Anderson, Bernard L. Schneider, Elodie Rey, Galyna Pidpruzhnykova, Selin Anil, Quentin Barraud, Stéphane Pagès, Polina Shkorbatova, Julie Kreider, Cristina Martinez-Gonzalez, Grégoire Courtine, Janine Beauparlant, Lucia Friedli, Laura Batti, Leonie Asboth

Publikováno v: Nature Neuroscience

Severe spinal cord contusions interrupt nearly all brain projections to lumbar circuits producing leg movement. Failure of these projections to reorganize leads to permanent paralysis. Here we modeled these injuries in rodents. A severe contusion abo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206a317ada2fa604980a9897091ed528

Engagement of the rat hindlimb motor cortex across natural locomotor behaviors

Autor: Rubia van den Brand, Simone Duis, Marco Schieppati, Grégoire Courtine, Janine Beauparlant, Lucia Friedli, Nadia Dominici, Silvestro Micera, Jacopo Rigosa, Jack DiGiovanna, Julie Kreider

Publikováno v: The Journal of Neuroscience, 36(40), 10440-10455. Society for Neuroscience
DiGiovanna, J, Dominici, N, Friedli, L, Rigosa, J, Duis, S, Kreider, J, Beauparlant, J, van den Brand, R, Schieppati, M, Micera, S & Courtine, G 2016, ' Engagement of the Rat Hindlimb Motor Cortex across Natural Locomotor Behaviors ', The Journal of Neuroscience, vol. 36, no. 40, pp. 10440-10455 . https://doi.org/10.1523/JNEUROSCI.4343-15.2016
Europe PubMed Central

Contrary to cats and primates, cortical contribution to hindlimb locomotor movements is not critical in rats. However, the importance of the motor cortex to regain locomotion after neurological disorders in rats suggests that cortical engagement in h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b09b25064b57ebd8c7e7b99db4b364
http://hdl.handle.net/11382/515207

Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates

Autor: Armin Curt, Yvette S. Nout-Lomas, Leif A. Havton, Jocelyne Bloch, Sarah C. Strand, Mark H. Tuszynski, Michael S. Beattie, Roland R. Roy, V. Reggie Edgerton, Sharon Zdunowski, Ephron S. Rosenzweig, Jacqueline C. Bresnahan, Hui Zhong, Martin Schubert, Adam R. Ferguson, Erwan Bezard, Rubia van den Brand, Nadia Dominici, Lea Awai, Pavel Musienko, Quentin Barraud, Jessica L. Nielson, Lucia Friedli, Grégoire Courtine

Publikováno v: Science translational medicine, vol 7, iss 302
Science Translational Medicine, 26(7):302. American Association for the Advancement of Science
Friedli, L, Rosenzweig, E, Barraud, Q, Schubert, M, Dominici, N, Awai, L, L. Nielson, J, Musienko, P, Nout-Lomas, Y, Zhong, H, Zdunowski, S, Roy, R, Strand, S, van den Brand, R, Havton, L, Beattie, M, Bresnahan, J, Bézard, E, Bloch, J, Edgerton, R, Ferguson, A, Curt, A, Tuszynski, M & Courtine, G 2015, ' Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates ', Science Translational Medicine, vol. 26, no. 7, 302, pp. 302ra134 . https://doi.org/10.1126/scitranslmed.aac5811
Science Translational Medicine

Experimental and clinical studies suggest that primate species exhibit greater recovery after lateralized compared to symmetrical spinal cord injuries. Although this observation has major implications for designing clinical trials and translational t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0de4521c7c203143ae0326f7c4e1370
https://doi.org/10.1126/scitranslmed.aac5811

Restoring voluntary control of locomotion after paralyzing spinal cord injury

Autor: Kay Bartholdi, Eduardo Martin Moraud, Silvestro Micera, Pavel Musienko, Janine Heutschi, Lucia Friedli, Isabel Vollenweider, Jack DiGiovanna, Grégoire Courtine, Nadia Dominici, Simone Duis, Quentin Barraud, Michèle Huerlimann, Rubia van den Brand

Publikováno v: van den Brand, R, Heutschi, J, Barraud, Q, DiGiovanna, J, Bartholdi, K, Huerlimann, M, Friedli, L, Vollenweider, I, Moraud, E M, Duis, S, Dominici, N, Micera, S, Musienko, P & Courtine, G 2012, ' Restoring voluntary control of locomotion after paralyzing spinal cord injury ', Science, vol. 336, no. 6085, pp. 1182-5 . https://doi.org/10.1126/science.1217416
Science, 336(6085), 1182-5. American Association for the Advancement of Science

Regaining Limb Movement Despite many years of intensive research, there is still an urgent need for novel treatments to help patients restore motor function after spinal cord injuries. van den Brand et al. (p. 1182 ) produced left and right hemisecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d8d529088e50dd5d426a3ff7f4d3d6
https://pubmed.ncbi.nlm.nih.gov/23087231

Decoding bipedal locomotion from the rat sensorimotor cortex

Autor: Grégoire Courtine, Nadia Dominici, R. van den Brand, Jack DiGiovanna, Lucia Friedli, Jacopo Rigosa, Silvestro Micera, Jacopo Carpaneto, Alessandro Panarese

Publikováno v: Rigosa, J, Panarese, A, Dominici, N, Friedli, L, van den Brand, R, Carpaneto, J, DiGiovanna, J, Courtine, G & Micera, S 2015, ' Decoding bipedal locomotion from the rat sensorimotor cortex ', Journal of Neural Engineering, vol. 12, no. 5 . https://doi.org/10.1088/1741-2560/12/5/056014
Journal of Neural Engineering, 12(5). IOP Publishing Ltd.

Objective. Decoding forelimb movements from the firing activity of cortical neurons has been interfaced with robotic and prosthetic systems to replace lost upper limb functions in humans. Despite the potential of this approach to improve locomotion a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62dfcca06f99c4ec7bc79a0a0d9230e
https://doi.org/10.1088/1741-2560/12/5/056014