Výsledky vyhledávání - "Lucia Fiorillo"

Akademický článek

LNA-i-miR-221 activity in colorectal cancer: A reverse translational investigation

Autor: Asad Ali, Katia Grillone, Serena Ascrizzi, Giulio Caridà, Lucia Fiorillo, Domenico Ciliberto, Nicoletta Staropoli, Pierosandro Tagliaferri, Pierfrancesco Tassone, Maria Teresa Di Martino

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102221- (2024)

Colorectal cancer (CRC) is one of the most common malignancies and a relevant cause of cancer-related deaths worldwide. Dysregulation of microRNA (miRNA) expression has been associated with the development and progression of various cancers, includin

Externí odkaz: https://doaj.org/article/3da076c66b4d4799a8feb9a8d50480d2

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Akademický článek

Safety and activity of the first-in-class locked nucleic acid (LNA) miR-221 selective inhibitor in refractory advanced cancer patients: a first-in-human, phase 1, open-label, dose-escalation study

Publikováno v: Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-12 (2023)

Abstract Background We developed a 13-mer locked nucleic acid (LNA) inhibitor of miR-221 (LNA-i-miR-221) with a full phosphorothioate (PS)-modified backbone. This agent downregulated miR-221, demonstrated anti-tumor activity against human xenografts

Externí odkaz: https://doaj.org/article/4d9a753abc2e49c2bbde30064f04d177

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Akademický článek

Autoimmune colitis and neutropenia in adjuvant anti-PD-1 therapy for malignant melanoma: efficacy of Vedolizumab, a case report

Autor: Maria d’Apolito, Rocco Spagnuolo, Maria Anna Siciliano, Vito Barbieri, Cristina Cosco, Lucia Fiorillo, Onofrio Cuomo, Valeria Zuccalà, Pierpaolo Correale, Licia Pensabene, Marco Rossi, Patrizia Doldo, Pierfrancesco Tassone, Pierosandro Tagliaferri

Publikováno v: Therapeutic Advances in Chronic Disease, Vol 13 (2022)

Immune checkpoint inhibitors (ICIs) represent an important advance in the adjuvant treatment of patients with high-risk melanoma. Although the safety profile of anti-programmed cell death protein-1 (PD-1) is fairly acceptable, different immune-relate

Externí odkaz: https://doaj.org/article/3140e4e3d7bb48529700ea1b69df5dc3

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Pegylated liposomal doxorubicin in the management of ovarian cancer

Autor: Michele Caraglia, Lucia Fiorillo, Stefania Lama, Domenico Ciliberto, Anna Grimaldi, Cirino Botta, Pierosandro Tagliaferri, Angela Salvino, Pierfrancesco Tassone, Nicoletta Staropoli

Publikováno v: Cancer Biology & Therapy. 15:707-720

Ovarian cancer is the leading cause of death among gynecological tumors. Carboplatin/paclitaxel represents the cornerstone of front-line treatment. Instead, there is no consensus for management of recurrent/progressive disease, in which pegylated lip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204197ef7e937bc4a040c6eb5dbaf90f
https://doi.org/10.4161/cbt.28557

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Target Therapy in Platinum-Refractory/Resistant Ovarian Cancer: From Preclinical Findings to Current Clinical Practice

Autor: Caterina Viscomi, Pierosandro Tagliaferri, Nicoletta Staropoli, Pierfrancesco Tassone, Cirino Botta, Simona Gualtieri, Domenico Ciliberto, Antonina Maria De Angelis, Lucia Fiorillo, Angela Salvino

Publikováno v: Journal of Cancer Therapy. :1005-1017

Epithelial ovarian cancer (EOC) is the sixth most common malignancy in women. Ovarian tumors consist of several clinical and pathological entities that share an anatomic site. The gold standard treatment, both in front-line and in adjuvant setting, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98390c1dd6d9950084334f8ccbc286aa
https://doi.org/10.4236/jct.2013.45115

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Microbiota and Chronic Inflammation as Targets for Colorectal Cancer Prevention

Autor: Eleonora Iuliano, Domenico Ciliberto, Lucia Fiorillo, Teresa Del Giudice, Pierosandro Tagliaferri

Publikováno v: Molecular Targets and Strategies in Cancer Prevention ISBN: 9783319312521

Recent findings have disclosed the complexity of large bowel microbiota which includes bacteria, viruses and unicellular eukaryotes. Bacteria represents 90 % of human gut microbiota.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2779b3399c0cd262f04acffcd5a0573d
https://doi.org/10.1007/978-3-319-31254-5_2

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A systematic review and meta-analysis of randomized trials on the role of targeted therapy in the management of advanced gastric cancer: Evidence does not translate?

Autor: F. Caglioti, Lucia Fiorillo, Francesco Mendicino, Pierosandro Tagliaferri, Cirino Botta, Domenico Ciliberto, Pierfrancesco Tassone, Nicoletta Staropoli, Silvia Chiellino, Simona Gualtieri, Antonina Maria De Angelis, Michele Caraglia

It is still uncertain if targeted therapy-based regimens in advanced gastric cancer actually produce survival benefit. To shed light on this important question, we performed a systematic review and meta-analyses on each relevant targeted-pathway. By

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668fa7309d7aaad4ea75fa8111f7d541
https://europepmc.org/articles/PMC4623405/

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Immunomodulatory activity of microRNAs: potential implications for multiple myeloma treatment

Autor: Pierfrancesco Tassone, Daniele Caracciolo, Pierosandro Tagliaferri, Lucia Fiorillo, Maria Cucè, Cirino Botta

Publikováno v: Current Cancer Drug Targets. 17:1-1

Multiple myeloma (MM) is an incurable plasma cell neoplasm accounting for about 10% of all hematologic malignancies. Recently, emerging evidence is disclosing the complexity of bone marrow interactions between MM cells and infiltrating immune cells,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d731c930e9b8ae462705167f5299222f
https://doi.org/10.2174/1568009617666170330154756

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Nanoparticle albumin bound Paclitaxel in the treatment of human cancer: nanodelivery reaches prime-time?

Autor: Amalia Luce, Pierosandro Tagliaferri, Pierfrancesco Tassone, Nicoletta Staropoli, Lucia Fiorillo, Simona Gualtieri, Michele Caraglia, Anna Grimaldi, Domenico Ciliberto, Iole Cucinotto, Mariamena Arbitrio

Publikováno v: Journal of Drug Delivery (Online) Volume 2013 (2013): 1–10.
info:cnr-pdr/source/autori:Iole Cucinotto,1 Lucia Fiorillo,1 Simona Gualtieri,1 Mariamena Arbitrio,2 Domenico Ciliberto,1 Nicoletta Staropoli,1 Anna Grimaldi,3 Amalia Luce,3 Pierfrancesco Tassone,1 Michele Caraglia,3 and Pierosandro Tagliaferri1/titolo:Nanoparticle albumin bound Paclitaxel in the treatment of human cancer: nanodelivery reaches prime-time?/doi:/rivista:Journal of Drug Delivery (Online)/anno:2013/pagina_da:1/pagina_a:10/intervallo_pagine:1–10/volume:Volume 2013
Journal of Drug Delivery, Vol 2013 (2013)
Journal of Drug Delivery

Nanoparticle albumin bound paclitaxel (nab-paclitaxel) represents the first nanotechnology-based drug in cancer treatment. We discuss the development of this innovative compound and report the recent changing-practice results in breast and pancreatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be530cecb04e22bed67c2750e5f69847
http://hdl.handle.net/11591/321178

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