Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Lucia Ferrazzano"'
Autor:
Lucia Ferrazzano, Alessandra Tolomelli, Ivan Guryanov, Marco Macis, Ulrich Abel, Antonio Ricci, Walter Cabri
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 4, Pp n/a-n/a (2023)
Abstract One of the main objectives of peptide drug design is the improvement of peptide pharmacokinetics with maintaining biological activity, which can be achieved by the complex modifications of the primary structure of the peptides. However, thes
Externí odkaz:
https://doaj.org/article/3e297e5c77ea43bc9bc771101bc0d848
Autor:
Alexia Mattellone, Dario Corbisiero, Paolo Cantelmi, Giulia Martelli, Chiara Palladino, Alessandra Tolomelli, Walter Cabri, Lucia Ferrazzano
Publikováno v:
Molecules, Vol 28, Iss 20, p 7183 (2023)
The growing applications of peptide-based therapeutics require the development of efficient protocols from the perspective of an industrial scale-up. T3P® (cyclic propylphosphonic anhydride) promotes amidation in the solution-phase through a biomime
Externí odkaz:
https://doaj.org/article/8e2861d3dee14e1aaff9503098aa8e8c
Autor:
Walter Cabri, Paolo Cantelmi, Dario Corbisiero, Tommaso Fantoni, Lucia Ferrazzano, Giulia Martelli, Alexia Mattellone, Alessandra Tolomelli
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Targeting protein-protein interactions (PPIs) has been recently recognized as an emerging therapeutic approach for several diseases. Up today, more than half a million PPI dysregulations have been found to be involved in pathological events. The dyna
Externí odkaz:
https://doaj.org/article/bebbb00d10bc48b8b623ec2bb61e43df
Autor:
Valentina Marassi, Marco Macis, Stefano Giordani, Lucia Ferrazzano, Alessandra Tolomelli, Barbara Roda, Andrea Zattoni, Antonio Ricci, Pierluigi Reschiglian, Walter Cabri
Publikováno v:
Molecules, Vol 27, Iss 17, p 5485 (2022)
Aggregation is among the most critical parameters affecting the pharmacological and safety profile of peptide Active Pharmaceutical Ingredients (APIs). For this reason, it is of utmost importance to define the exact aggregation state of peptide drugs
Externí odkaz:
https://doaj.org/article/3a000fa811c64b4589598430ebb66b3a
Autor:
Andrea Orlandin, Ivan Guryanov, Lucia Ferrazzano, Barbara Biondi, Francesca Biscaglia, Claudia Storti, Marzio Rancan, Fernando Formaggio, Antonio Ricci, Walter Cabri
Publikováno v:
Molecules, Vol 27, Iss 13, p 4235 (2022)
The suppression of side reactions is one of the most important objectives in peptide synthesis, where highly reactive compounds are involved. Recently, the violuric acid derivative Oxyma-B was introduced into peptide synthesis protocols as a promisin
Externí odkaz:
https://doaj.org/article/277953ee4012404191fe2e82aac0ffa7
Autor:
Giulio Lievore, Desiree Bozza, Martina Catani, Alberto Cavazzini, Tatiana Chenet, Luisa Pasti, Lucia Ferrazzano, Walter Cabri, Marco Macis, Antonio Ricci, Chiara De Luca, Simona Felletti
Publikováno v:
Separations, Vol 9, Iss 5, p 125 (2022)
Peptides are a class of biomolecules with a great potential from the therapeutic point of view, because of their unique biological properties. Industrially, the production stategies adopted produce both the target peptide and a series of impurities t
Externí odkaz:
https://doaj.org/article/b268196421f64f0ab1c99ef7ea9823d2
Autor:
Manuela Grimaldi, Angelo Santoro, Michela Buonocore, Claudio Crivaro, Nicola Funicello, Matilde Sublimi Saponetti, Cristina Ripoli, Manuela Rodriquez, Salvatore De Pasquale, Fabrizio Bobba, Lucia Ferrazzano, Walter Cabri, Anna Maria D’Ursi, Antonio Ricci
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 681 (2022)
The supramolecular structure in peptides’ prolonged-released gel formulations is the most critical parameter for the determination of the pharmaceutical profile of the drug. Here, we report our investigation on lanreotide Autogel as a case study. F
Externí odkaz:
https://doaj.org/article/0b98b6d66c1a4eb8a791f49b212e9b0f
Autor:
Monica Baiula, Roberto Greco, Lucia Ferrazzano, Alberto Caligiana, Klarida Hoxha, Daniele Bandini, Pasquale Longobardi, Santi Spampinato, Alessandra Tolomelli
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237746 (2020)
In recent years, several studies suggested that the ability of hyperbaric oxygen therapy (HBOT) to promote healing in patients with diabetic ulcers and chronic wounds is due to the reduction of inflammatory cytokines and to a significant decrease in
Externí odkaz:
https://doaj.org/article/8253affc5fe14eab87a3bd9adc061688
Autor:
Alexia Mattellone, Dario Corbisiero, Lucia Ferrazzano, Paolo Cantelmi, Giulia Martelli, Chiara Palladino, Alessandra Tolomelli, Walter Cabri
Publikováno v:
Green Chemistry. 25:2563-2571
A fast and greensolution-phase peptide synthesis (GSolPPS) via continuous protocol, addressed with propylphosphonic anhydride T3P® as coupling reagent and N-benzyloxycarbonyl-protecting group easily removed by hydrogenation is herein reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::822486f6962774f8c2d3dd1c50f3ad29
https://doi.org/10.1039/d3gc00431g
https://doi.org/10.1039/d3gc00431g
Publikováno v:
Green Chemistry. 25:1217-1236
Can the green innovations introduced in peptide synthesis be transferred to oligonucleotide manufacturing? A critical analysis to disclose the green potential of TIDES.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1298f66a9dc6fdb6fd20a1f0ae3aa8e
https://doi.org/10.1039/d2gc04547h
https://doi.org/10.1039/d2gc04547h