Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Lucia E.A. de Wit"'
Autor:
Brenda C. M. de Winter, Dennis A. Hesselink, Yi Li, Ron H.N. van Schaik, Lin Yang, Birgit C. P. Koch, Marith I. Francke, Teun van Gelder, Carla C. Baan, Lucia E.A. de Wit
Publikováno v:
British Journal of Clinical Pharmacology
British Journal of Clinical Pharmacology, 87(4), 1918-1929. Wiley-Blackwell Publishing Ltd
British Journal of Clinical Pharmacology, 87(4), 1918-1929. Wiley-Blackwell Publishing Ltd
Aims: Tacrolimus is a critical dose drug and to avoid under- and overexposure, therapeutic drug monitoring is standard practice. However, rejection and drug-related toxicity occur despite whole-blood tacrolimus pre-dose concentrations ([Tac]blood) be
Autor:
Soma Bahmany, Lucia E.A. de Wit, Birgit C. P. Koch, Teun van Gelder, Brenda C. M. de Winter, Nauras Shuker, Bart C. H. van der Nagel, Carla C. Baan, Dennis A. Hesselink
Publikováno v:
Biomedical Chromatography
Biomedical Chromatography, 33(1):e4416. John Wiley & Sons Ltd.
Biomedical Chromatography, 33(1):e4416. John Wiley & Sons Ltd.
After solid organ transplantation, tacrolimus is given to prevent rejection. Therapeutic drug monitoring is used to reach target concentrations of tacrolimus in whole blood. Because the site of action of tacrolimus is the lymphocyte, and tacrolimus b