Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lucia Ciglar"'
Autor:
Stefania Vetrano, Gerben Bouma, Robert J. Benschop, Thomas Birngruber, Antonio Costanzo, G. R. A. M. D’Haens, Loredana Frasca, Rainer Hillenbrand, Lars Iversen, Claus Johansen, Arthur Kaser, Hans J. P. M. Koenen, Christa Noehammer, Laurent Peyrin-Biroulet, Jeroen Raes, Leonardo Ricotti, Philip Rosenstiel, Venkata P. Satagopam, Stefan Schreiber, Severine Vermeire, Andreas Wollenberg, Stephan Weidinger, Daniel Ziemek, Silvio Danese, ImmUniverse Consortium, Alessandro Armuzzi, Alessia Butera, Andrea Cafarelli, Lucia Ciglar, Ellen van den Bogaard, Elke MGJ de Jong, Ernst Dow, Marjolijn Duijvenstein, Ahmed Essaghir, Rebecca Favaro, Gionata Fiorino, Soumyabrata Ghosh, Wei Gu, Robert Häsler, Xuehui He, Roberto Lande, Judith Logmans, Christoph Magnes, Karl Nocka, Loulou Peisl, Samuel Pineda Chavez, Angela Sorriento, Klemens Vierlinger, Laurien Waaijer, Xinhui Wang, Nicolas Wisniacki, Mary Zuniga
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immune mediated inflammatory diseases (IMIDs) are a heterogeneous group of debilitating, multifactorial and unrelated conditions featured by a dysregulated immune response leading to destructive chronic inflammation. The immune dysregulation can affe
Externí odkaz:
https://doaj.org/article/25c0b3e1103d4243ac5ad47318b6a393
Autor:
Pierre Khoueiry, Charles Girardot, Lucia Ciglar, Pei-Chen Peng, E Hilary Gustafson, Saurabh Sinha, Eileen EM Furlong
Publikováno v:
eLife, Vol 6 (2017)
Sequence variation within enhancers plays a major role in both evolution and disease, yet its functional impact on transcription factor (TF) occupancy and enhancer activity remains poorly understood. Here, we assayed the binding of five essential TFs
Externí odkaz:
https://doaj.org/article/fce93f30087a461aa37aed06d6e5aa2d
Autor:
Abibatou Mbodj, E Hilary Gustafson, Lucia Ciglar, Guillaume Junion, Aitor Gonzalez, Charles Girardot, Laurent Perrin, Eileen E M Furlong, Denis Thieffry
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 9, p e1005073 (2016)
Given the complexity of developmental networks, it is often difficult to predict the effect of genetic perturbations, even within coding genes. Regulatory factors generally have pleiotropic effects, exhibit partially redundant roles, and regulate hig
Externí odkaz:
https://doaj.org/article/6b6676f535d7491d8a3efa115b6e2058
Autor:
Paulo M F Cunha, Thomas Sandmann, E Hilary Gustafson, Lucia Ciglar, Michael P Eichenlaub, Eileen E M Furlong
Publikováno v:
PLoS Genetics, Vol 6, Iss 7, p e1001014 (2010)
Understanding how complex patterns of temporal and spatial expression are regulated is central to deciphering genetic programs that drive development. Gene expression is initiated through the action of transcription factors and their cofactors conver
Externí odkaz:
https://doaj.org/article/00363e2f2f57489aa48f0082a5b26fc8
Autor:
E. Hilary Gustafson, Eileen E. M. Furlong, Pierre Khoueiry, Lucia Ciglar, Jan O. Korbel, Enrico Cannavò, Paul Geeleher, David A. Garfield, Thomas Zichner
Publikováno v:
Current Biology
Summary Embryogenesis is remarkably robust to segregating mutations and environmental variation; under a range of conditions, embryos of a given species develop into stereotypically patterned organisms. Such robustness is thought to be conferred, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0c10e4ba2bba5980910a6ad8eb20b1
http://europepmc.org/articles/PMC4712172
http://europepmc.org/articles/PMC4712172
Autor:
E. Hilary Gustafson, Lucia Ciglar, Charles Girardot, Pierre Khoueiry, Saurabh Sinha, Eileen E. M. Furlong, Pei-Chen Peng
Publikováno v:
eLife, Vol 6 (2017)
eLife
eLife
Sequence variation within enhancers plays a major role in both evolution and disease, yet its functional impact on transcription factor (TF) occupancy and enhancer activity remains poorly understood. Here, we assayed the binding of five essential TFs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707ee41de83eabdba5b9df68125bd515
https://doi.org/10.7554/elife.28440
https://doi.org/10.7554/elife.28440
Publikováno v:
Development (Cambridge, England)
Molecular models of cell fate specification typically focus on the activation of specific lineage programs. However, the concurrent repression of unwanted transcriptional networks is also essential to stabilize certain cellular identities, as shown i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49aa76b6c586b066803388c2b9b88f2c
https://doi.org/10.1242/dev.101956
https://doi.org/10.1242/dev.101956
Autor:
Dermot Harnett, Lucia Ciglar, Rebecca Rodríguez Viales, Nils Koelling, Oliver Stegle, Jacob F. Degner, Enrico Cannavò, Eileen E. M. Furlong, Raquel Marco-Ferreres, Francesco Paolo Casale, David A. Garfield, Ewan Birney, Bingqing Zhao, Hilary E. Gustafson
Publikováno v:
Nature. 541(7637)
Embryonic development is driven by tightly regulated patterns of gene expression, despite extensive genetic variation among individuals. Studies of expression quantitative trait loci (eQTL) indicate that genetic variation frequently alters gene expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29cf4677e9ef10f4429a917fc4cb9719
https://pubmed.ncbi.nlm.nih.gov/28024300
https://pubmed.ncbi.nlm.nih.gov/28024300
Autor:
Daan Noordermeer, Yad Ghavi-Helm, Tibor Pakozdi, Lucia Ciglar, Eileen E. M. Furlong, Wolfgang Huber, Felix A. Klein
Publikováno v:
Nature
Nature, Nature Publishing Group, 2014, 512 (7512), pp.96-100. ⟨10.1038/nature13417⟩
Nature, Nature Publishing Group, 2014, 512 (7512), pp.96-100. ⟨10.1038/nature13417⟩
Developmental enhancers initiate transcription and are fundamental to our understanding of developmental networks, evolution and disease. Despite their importance, the properties governing enhancer-promoter interactions and their dynamics during embr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b12a2c16b93a8e2ac97b3d5d31e54d2
https://hal.archives-ouvertes.fr/hal-02349085
https://hal.archives-ouvertes.fr/hal-02349085
