Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Lucia Carbone"'
Autor:
Mariam Okhovat, Jake VanCampen, Kimberly A. Nevonen, Lana Harshman, Weiyu Li, Cora E. Layman, Samantha Ward, Jarod Herrera, Jackson Wells, Rory R. Sheng, Yafei Mao, Blaise Ndjamen, Ana C. Lima, Katinka A. Vigh-Conrad, Alexandra M. Stendahl, Ran Yang, Lev Fedorov, Ian R. Matthews, Sarah A. Easow, Dylan K. Chan, Taha A. Jan, Evan E. Eichler, Sandra Rugonyi, Donald F. Conrad, Nadav Ahituv, Lucia Carbone
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Topological associating domains (TADs) are self-interacting genomic units crucial for shaping gene regulation patterns. Despite their importance, the extent of their evolutionary conservation and its functional implications remain largely un
Externí odkaz:
https://doaj.org/article/65e9bbc94a464705ac4ea7c071b55e77
Autor:
William M. Yashar, Garth Kong, Jake VanCampen, Brittany M. Curtiss, Daniel J. Coleman, Lucia Carbone, Galip Gürkan Yardimci, Julia E. Maxson, Theodore P. Braun
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-21 (2022)
Abstract Genome-wide mapping of histone modifications is critical to understanding transcriptional regulation. CUT&Tag is a new method for profiling histone modifications, offering improved sensitivity and decreased cost compared with ChIP-seq. Here,
Externí odkaz:
https://doaj.org/article/fa4eea9616d44b6d96d8aee92ef7b348
Autor:
Jimi L. Rosenkrantz, Jessica E. Gaffney, Victoria H. J. Roberts, Lucia Carbone, Shawn L. Chavez
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-22 (2021)
Abstract Background Proper placentation, including trophoblast differentiation and function, is essential for the health and well-being of both the mother and baby throughout pregnancy. Placental abnormalities that occur during the early stages of de
Externí odkaz:
https://doaj.org/article/13f49107236a4116b7229d11567c464e
Autor:
Jacob Gutierrez, Brett A. Davis, Kimberly A. Nevonen, Samantha Ward, Lucia Carbone, Cheryl L. Maslen
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Turner Syndrome (TS) is a rare cytogenetic disorder caused by the complete loss or structural variation of the second sex chromosome. The most common cause of early mortality in TS results from a high incidence of left-sided congenital heart defects,
Externí odkaz:
https://doaj.org/article/cae7f1ff621c41809080dbf7bd61798f
Autor:
Payel Kundu, Eileen Ruth S. Torres, Keaton Stagaman, Kristin Kasschau, Mariam Okhovat, Sarah Holden, Samantha Ward, Kimberly A. Nevonen, Brett A. Davis, Takashi Saito, Takaomi C. Saido, Lucia Carbone, Thomas J. Sharpton, Jacob Raber
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract Epigenetic mechanisms occurring in the brain as well as alterations in the gut microbiome composition might contribute to Alzheimer’s disease (AD). Human amyloid precursor protein knock-in (KI) mice contain the Swedish and Iberian mutation
Externí odkaz:
https://doaj.org/article/eabb5988f5e94c96a3c3a0cc1f5de7bc
Autor:
Nathan D. Pennock, Sonali Jindal, Wesley Horton, Duanchen Sun, Jayasri Narasimhan, Lucia Carbone, Suzanne S. Fei, Robert Searles, Christina A. Harrington, Julja Burchard, Sheila Weinmann, Pepper Schedin, Zheng Xia
Publikováno v:
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-18 (2019)
Abstract Background Formalin-fixed, paraffin-embedded (FFPE) tissues for RNA-seq have advantages over fresh frozen tissue including abundance and availability, connection to rich clinical data, and association with patient outcomes. However, FFPE-der
Externí odkaz:
https://doaj.org/article/23cdb8883d2b4c058fc474177b85152b
Autor:
Theodore P. Braun, Mariam Okhovat, Cody Coblentz, Sarah A. Carratt, Amy Foley, Zachary Schonrock, Brittany M. Smith, Kimberly Nevonen, Brett Davis, Brianna Garcia, Dorian LaTocha, Benjamin R. Weeder, Michal R. Grzadkowski, Joey C. Estabrook, Hannah G. Manning, Kevin Watanabe-Smith, Sophia Jeng, Jenny L. Smith, Amanda R. Leonti, Rhonda E. Ries, Shannon McWeeney, Cristina Di Genua, Roy Drissen, Claus Nerlov, Soheil Meshinchi, Lucia Carbone, Brian J. Druker, Julia E. Maxson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Acute Myeloid Leukemia (AML) develops following multiple mutations of differing impact. Here, the authors show that activating mutations of CSF3R co-operate with loss-of-function mutations of CEBPA to promote AML development through an enhancer-depen
Externí odkaz:
https://doaj.org/article/c4f5920cda714e2080bbc04d4c0c3d87
Autor:
Theodore P. Braun, Mariam Okhovat, Cody Coblentz, Sarah A. Carratt, Amy Foley, Zachary Schonrock, Brittany M. Curtiss, Kimberly Nevonen, Brett Davis, Brianna Garcia, Dorian LaTocha, Benjamin R. Weeder, Michal R. Grzadkowski, Joey C. Estabrook, Hannah G. Manning, Kevin Watanabe-Smith, Sophia Jeng, Jenny L. Smith, Amanda R. Leonti, Rhonda E. Ries, Shannon McWeeney, Cristina Di Genua, Roy Drissen, Claus Nerlov, Soheil Meshinchi, Lucia Carbone, Brian J. Druker, Julia E. Maxson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/c3c2338ac9144f60aac72e27a406a213
Autor:
Christopher J. Harris, Brett A. Davis, Jonathan A. Zweig, Kimberly A. Nevonen, Joseph F. Quinn, Lucia Carbone, Nora E. Gray
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
As the population ages, interest in identifying biomarkers of healthy aging and developing antiaging interventions has increased. DNA methylation has emerged as a potentially powerful molecular marker of aging. Methylation changes at specific sites i
Externí odkaz:
https://doaj.org/article/64d386af1b4f4654b5b7dc4185cb4e3e
Autor:
David P. Gavin, Joel G. Hashimoto, Nathan H. Lazar, Lucia Carbone, John C. Crabbe, Marina Guizzetti
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Alcohol use disorder (AUD) is a chronic mental illness in which patients often achieve protracted periods of abstinence prior to relapse. Epigenetic mechanisms may provide an explanation for the persisting gene expression changes that can be observed
Externí odkaz:
https://doaj.org/article/f27f20705f744d7ab502164996bd65e9