Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Lucia A, Possamai"'
Autor:
Nick Powell, Mark R Thursz, Kevin J Woollard, James Larkin, Samra Turajlic, Stephen R Atkinson, Robert D Goldin, Evangelos Triantafyllou, Lucia A Possamai, Charalambos G Antoniades, Cathrin L C Gudd, Eoin Mitchell, Marie-Anne Mawhin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Checkpoint inhibitor-induced hepatitis (CPI-hepatitis) is an emerging problem with the widening use of CPIs in cancer immunotherapy. Here, we developed a mouse model to characterize the mechanism of CPI-hepatitis and to therapeutically tar
Externí odkaz:
https://doaj.org/article/ef7d49df3e824b6ba015b5adda0e950e
Autor:
Jonathan W. Lo, Domenico Cozzetto, James L. Alexander, Nathan P. Danckert, Matthew Madgwick, Naomi Knox, Jillian Yong Xin Sieh, Marton Olbei, Zhigang Liu, Hajir Ibraheim, Jesus Miguens Blanco, Hiromi Kudo, Rocio Castro Seoane, Lucia A. Possamai, Robert Goldin, Julian Marchesi, Tamas Korcsmaros, Graham M. Lord, Nick Powell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Immune checkpoint inhibitors (CPIs) are a relatively newly licenced cancer treatment, which make a once previously untreatable disease now amenable to a potential cure. Combination regimens of anti-CTLA4 and anti-PD-1 show enhanced efficacy
Externí odkaz:
https://doaj.org/article/e664d0e3c68643ff903f07ec1b951c4e
Autor:
Parvin Begum, MBChB.(Hons), Robert D. Goldin, MD, Lucia A. Possamai, PhD, Sanjay Popat, FRCP, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 2, Iss 9, Pp 100213- (2021)
Sotorasib is a first-in-class small molecule that irreversibly inhibits KRAS G12C, locking it in an inactive state, inhibiting oncogenic signaling, and inducing a proinflammatory microenvironment. Here, we report the first case of life-threatening he
Externí odkaz:
https://doaj.org/article/d35246bc42e64d37a88a15bf7ca7fe13
Autor:
Evangelos Triantafyllou, Kevin J. Woollard, Mark J. W. McPhail, Charalambos G. Antoniades, Lucia A. Possamai
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Acute and acute-on-chronic liver failure (ALF and ACLF), though distinct clinical entities, are considered syndromes of innate immune dysfunction. Patients with ALF and ACLF display evidence of a pro-inflammatory state with local liver inflammation,
Externí odkaz:
https://doaj.org/article/30634139b4d8409ead9d5b3c752a09cc
Autor:
Cathrin Gudd, Robert D. Goldin, Rooshi Nathwani, You Yone, Charalambos G. Antoniades, James Larkin, A. Dhar, Sujit Mukherjee, Tong Liu, Evangelos Triantafyllou, Lewis Au, Benjamin Shum, Lucia A. Possamai, Samra Turajlic, David J. Pinato, Kevin J. Woollard, Naveenta Kumar, Mark Thursz, Martin Gore, Wafa Khamri
Publikováno v:
Journal of Hepatology. 75:177-189
Background & Aims: Checkpoint inhibitor-related hepatitis (CPI-Hep) is an emerging clinical challenge. We aimed to gain insights into the immunopathology of CPI-Hep by comprehensively characterising myeloid and lymphoid subsets. Methods: CPI-treated
Anti-programmed death receptor-1 (anti-PD-1) monoclonal antibodies (mAbs) are used to treat an increasing range of cancers. However, the distinct toxicity profile of immune-related adverse events (irAEs) is a frequent drawback of their clinical appli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d8f9f6065becb47d1b23db09b9fb309
http://hdl.handle.net/10044/1/99452
http://hdl.handle.net/10044/1/99452
Autor:
Cathrin Gudd, Sujit Mukherjee, Arjuna Singanayagam, Christopher J. Weston, Lucia A. Possamai, Fanny Lebossé, Rooshi Nathwani, Thomas A Barbera, Evangelos Triantafyllou, Sofia Azam, Charalambos G. Antoniades, Mark J. W. McPhail, Naveenta Kumar, Francesca M. Trovato, Marigona Krasniqi, Mark Thursz, Wafa Khamri, Tong Liu, C. Bernsmeier, Rocio Castro Seoane
ObjectiveIdentifying components of immuneparesis, a hallmark of chronic liver failure, is crucial for our understanding of complications in cirrhosis. Various suppressor CD4+T cells have been established as potent inhibitors of systemic immune activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10a00d06045cb18fd2d5514f5a01aa5
http://hdl.handle.net/10044/1/90704
http://hdl.handle.net/10044/1/90704
Autor:
Dariusz Lachowski, Ernesto Cortes, Antonios Chronopoulos, Alistair Rice, David A. Lee, Haiyun Wang, Armando del Río Hernández, Lucia A. Possamai, Stephen D. Thorpe, David J. Pinato, Benjamin Robinson
Publikováno v:
Hepatology. 69:785-802
Hepatic stellate cells (HSCs) are essential perisinusoidal cells in the healthy and diseased liver. HSCs modulate extracellular matrix (ECM) homeostasis when quiescent, but in liver fibrosis, HSCs become activated and promote excess deposition of ECM
Autor:
Matthew K. Siggins, Wafa Khamri, Thomas O’Connor, Evangelos Triantafyllou, Mark Thursz, Marie-Anne Mawhin, Mark J. W. McPhail, Hannah C. Husbyn, Kevin J. Woollard, Sujit Mukherjee, Marina Botto, Cathrin Gudd, Robert D. Goldin, Christine Bernsmeier, Charalambos G. Antoniades, Lucia A. Possamai, Francesca M. Trovato, Julia Wendon, Hiromi Kudo
Publikováno v:
The Journal of Clinical Investigation
Patients with acute liver failure (ALF) have systemic innate immune suppression and increased susceptibility to infections. Programmed cell death 1 (PD-1) expression by macrophages has been associated with immune suppression during sepsis and cancer.
Autor:
Cathrin L. C. Gudd, Lucia A. Possamai
Publikováno v:
Cancers. 14:1913
Drug-related hepatotoxicity is an emerging clinical challenge with the widening use of immunotherapeutic agents in the field of oncology. This is an important complication to consider as more immune oncological targets are being identified to show pr