Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Lucia Lassiani"'
Publikováno v:
Pharmaceuticals
Research on the adenosine receptors has been supported by the continuous discovery of new chemical probes characterized by more and more affinity and selectivity for the single adenosine receptor subtypes (A1, A2A, A2B and A3 adenosine receptors). Fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1db4d38687ecc8e5cc17bf81c7beff
https://pubmed.ncbi.nlm.nih.gov/31726680
https://pubmed.ncbi.nlm.nih.gov/31726680
Autor:
Matteo Lusi, Miranda L. Perry, Michael J. Zaworotko, Dario Voinovich, Samuel Golob, Michele R. Chierotti, Lucia Lassiani, Iztok Grabnar
Publikováno v:
Journal of Pharmaceutical Sciences. 105:3626-3633
Vinpocetine is a poorly water soluble weakly basic drug (pKa = 7.1) used for the treatment of several cerebrovascular and cognitive disorders. Because existing formulations exhibit poor bioavailability and scarce absorption, a dosage form with improv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbde70d38da5182d2983eddbf24cf04e
https://doi.org/10.1016/j.xphs.2016.09.017
https://doi.org/10.1016/j.xphs.2016.09.017
Autor:
Giuseppe Procida, Sara Drioli, Marina Zacchigna, Francesca Cateni, Patrizia Nitti, Marco Pelin, Lucia Lassiani, Chiara Florio
The α-methylene-γ-butyrolactone skeleton is part of many natural products with remarkable biological properties. C75, a fatty acid synthase (FAS) inhibitor, is a synthetic α-methylene-γ-butyrolactone which is cytotoxic for different cell lines in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ec1e11735eb7483452e6cb2006e404
http://hdl.handle.net/11368/2933536
http://hdl.handle.net/11368/2933536
Autor:
Antonio Varnavas, Federico Berti, Theodoros Markidis, Francesco Makovec, Laura Mennuni, George Kokotos, Lucia Lassiani, Michela V. Pavan
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:2336-2350
The anthranilic acid diamides represent the more recent class of nonpeptide CCK(1) receptor antagonists. This class is characterized by the presence of anthranilic acid, used as a molecular scaffold, and two pharmacophores selected from the C-termina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db791ac364cb18aa427415ab456a8e83
https://doi.org/10.1016/j.bmc.2009.02.012
https://doi.org/10.1016/j.bmc.2009.02.012
Publikováno v:
Il Farmaco. 55:293-302
A series of C-terminal anthranoyl-anthranilic acid derivatives arising from a strict bond disconnection approach of asperlicin were synthesized and examined for their CCK receptor affinities. These compounds represent the second step of our investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea14a88cb5cec16d4c923207135db5f
https://doi.org/10.1016/s0014-827x(00)00043-4
https://doi.org/10.1016/s0014-827x(00)00043-4
Autor:
Federico Berti, Laura Mennuni, Lucia Lassiani, Flora Ferrari, Alessia Ciogli, Francesco Makovec, Daniel Fourmy, Antonio Varnavas, Chantal Escrieut, Giorgio Stefancich, Francesco Gasparrini, Esther Marco, Michela V. Pavan
The anthranilic acid diamides represent the most recent class of nonpeptide CCK(1) receptor (CCK(1)-R) antagonists. Herein we describe the second phase of the anthranilic acid C-terminal optimization using nonproteinogenic amino acids containing a ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d53c4bddd1e8d47f015714250acdc23
http://hdl.handle.net/11573/390098
http://hdl.handle.net/11573/390098
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33940faa0add4ef5d8975ec7cb8a3204
https://doi.org/10.1002/chin.199144219
https://doi.org/10.1002/chin.199144219
Publikováno v:
ChemInform. 23
The hydrosoluble triazene derivatives of phenylacetic, phenylbutyric and cinnamic acid have been synthesized and their logP and pKa values were simultaneously determined according to a multiparametric fitting of potentiometric data. The antitumor act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba98b44c49f0e5c60af1ec67b97d81ce
https://doi.org/10.1002/chin.199220129
https://doi.org/10.1002/chin.199220129
Publikováno v:
ChemInform. 27
A series of 2-methyl-3-amino-4(H)-quinazolinone and of 2-phenyl-3-amino-4(H)-quinazolinone derivatives were synthesized and examined for their CCK receptor affinities. These compounds displayed micromolar affinities for CCK-B rather than CCK-A recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf600b65903bb9b4ab0890e651d99f03
https://doi.org/10.1002/chin.199642162
https://doi.org/10.1002/chin.199642162
Publikováno v:
ChemInform. 31
We have described previously an innovative bond disconnection strategy of asperlicin, a naturally occurring CCK receptor antagonist, leading to anthranilic acid dimer and tryptophan synthons. We have also demonstrated that when the tryptophan residue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dd6f243ef30c22b02bea8c17e7db9f8
https://doi.org/10.1002/chin.200046196
https://doi.org/10.1002/chin.200046196