Unveiling the mechanism of action of acylated temporin L analogues against multidrug-resistant Candida albicans

Autor: Rosa Bellavita, Annarita Falanga, Francesco Merlino, Gabriella D’Auria, Nicola Molfetta, Anella Saviano, Francesco Maione, Umberto Galdiero, Maria Rosaria Catania, Stefania Galdiero, Paolo Grieco, Emanuela Roscetto, Lucia Falcigno, Elisabetta Buommino

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 36-50 (2023)

The increasing resistance of fungi to conventional antifungal drugs has prompted worldwide the search for new compounds. In this work, we investigated the antifungal properties of acylated Temporin L derivatives, Pent-1B and Dec-1B, against Candida a

Externí odkaz: https://doaj.org/article/39c43ad04aa145468deb70d283b01f6c

Chitosan Covalently Functionalized with Peptides Mapped on Vitronectin and BMP-2 for Bone Tissue Engineering

Autor: Paola Brun, Annj Zamuner, Leonardo Cassari, Gabriella D’Auria, Lucia Falcigno, Stefano Franchi, Giorgio Contini, Martina Marsotto, Chiara Battocchio, Giovanna Iucci, Monica Dettin

Publikováno v: Nanomaterials, Vol 11, Iss 11, p 2784 (2021)

Worldwide, over 20 million patients suffer from bone disorders annually. Bone scaffolds are designed to integrate into host tissue without causing adverse reactions. Recently, chitosan, an easily available natural polymer, has been considered a suita

Externí odkaz: https://doaj.org/article/036a04e68d2d4490804f875567c6dcb4

Insights into the Interaction Mechanism of DTP3 with MKK7 by Using STD-NMR and Computational Approaches

Autor: Annamaria Sandomenico, Lorenzo Di Rienzo, Luisa Calvanese, Emanuela Iaccarino, Gabriella D’Auria, Lucia Falcigno, Angela Chambery, Rosita Russo, Guido Franzoso, Laura Tornatore, Marco D’Abramo, Menotti Ruvo, Edoardo Milanetti, Domenico Raimondo

Publikováno v: Biomedicines, Vol 9, Iss 1, p 20 (2020)

GADD45β/MKK7 complex is a non-redundant, cancer cell-restricted survival module downstream of the NF-kB survival pathway, and it has a pathogenically critical role in multiple myeloma, an incurable malignancy of plasma cells. The first-in-class GADD

Externí odkaz: https://doaj.org/article/830a5a16f29844b08bd60fdf714a01ec

New structural determinants for antimicrobial peptides?

Autor: Lucia Falcigno, Gabriella D’Auria, Marco Balestrieri, Marta Gogliettino, Bruna Agrillo, Rosaria Tatè, Principia Dardano, Luigi Nicolais, Gianna Palmieri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::890ebcfdd425ed2d937c4135b1696a9f
http://hdl.handle.net/11588/888690

Key physicochemical determinants in the antimicrobial peptide RiLK1 promote amphipathic structures

Autor: Gabriella D'Auria, Marta Gogliettino, Luigi Nicolais, Bruna Agrillo, Marco Balestrieri, Gianna Palmieri, Lucia Falcigno, Principia Dardano, Rosarita Tatè

Publikováno v: International journal of molecular sciences
22 (2021). doi:10.3390/ijms221810011
info:cnr-pdr/source/autori:Falcigno, Lucia; D'auria, Gabriella; Palmieri, Gianna; Gogliettino, Marta; Agrillo, Bruna; Tatè, Rosarita; Dardano, Principia; Nicolais, Luigi; Balestrieri, Marco/titolo:Key physicochemical determinants in the antimicrobial peptide RiLK1 promote amphipathic structures/doi:10.3390%2Fijms221810011/rivista:International journal of molecular sciences (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:22
International Journal of Molecular Sciences
Volume 22
Issue 18
International Journal of Molecular Sciences, Vol 22, Iss 10011, p 10011 (2021)

Antimicrobial peptides (AMPs) represent a skilled class of new antibiotics, due to their broad range of activity, rapid killing, and low bacterial resistance. Many efforts have been made to discover AMPs with improved performances, i.e., high antimic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b0a1b5772ee30211797a5e407105fd
http://hdl.handle.net/11588/873901