Zobrazeno 1 - 10
of 493
pro vyhledávání: '"Lucia Altucci"'
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-4 (2024)
Abstract Gene expression is an intricate biological process that bridges gap between the genotype and the phenotype. Canonical and hereditable epigenetic mechanisms, such as histone and DNA modifications, regulate the release of genetic information e
Externí odkaz:
https://doaj.org/article/a3c1e332af5f46608acfc61505896699
Autor:
Chiara Papulino, Ugo Chianese, Ahmad Ali, Gregorio Favale, Concetta Tuccillo, Fortunato Ciardiello, Annabella Di Mauro, Chiara Mignogna, Gerardo Ferrara, Alfredo Budillon, Wouter Leonard Megchelenbrink, Nunzio Del Gaudio, Mariarosaria Conte, Fabrizio Merciai, Pietro Campiglia, Lucia Altucci, Vincenzo Carafa, Eduardo Sommella, Rosaria Benedetti
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Breast cancer manifests as a heterogeneous pathology marked by complex metabolic reprogramming essential to satisfy its energy demands. Oncogenic signals boost the metabolism, modifying fatty acid synthesis and glucose use from th
Externí odkaz:
https://doaj.org/article/e1c9da9a03da4c08b5e34b1d243a2230
Autor:
Valentina Rossi, Erika Di Zazzo, Giovanni Galasso, Caterina De Rosa, Ciro Abbondanza, Antonio A. Sinisi, Lucia Altucci, Antimo Migliaccio, Gabriella Castoria
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/4aa4f7b8b50846bb99206124a96ca84f
Autor:
Eduardo Ibello, Federica Saracino, Donatella Delle Cave, Silvia Buonaiuto, Filomena Amoroso, Gennaro Andolfi, Marco Corona, Ombretta Guardiola, Vincenza Colonna, Bruno Sainz Jr, Lucia Altucci, Dario De Cesare, Gilda Cobellis, Enza Lonardo, Eduardo Jorge Patriarca, Cristina D’Aniello, Gabriella Minchiotti
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-20 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is the most lethal cancer with an aggressive metastatic phenotype and very poor clinical prognosis. Interestingly, a lower occurrence of PDAC has been described in individuals with severe an
Externí odkaz:
https://doaj.org/article/b556c8edf2144cd3bd73b86564712a67
Autor:
Liliana Montella, Luigi Di Marino, Maria Adele Marino, Vittorio Riccio, Nunzio Del Gaudio, Lucia Altucci, Massimiliano Berretta, Gaetano Facchini
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundHormone receptor-positive tumors are unlikely to exhibit a complete pathological tumor response. The association of CDK 4/6 inhibitor plus hormone therapy has changed this perspective.Case presentationIn this study, we retrospectively revie
Externí odkaz:
https://doaj.org/article/7505e308e5744e11b929d6a0c6747758
Autor:
Jessica Lombino, Rosario Vallone, Maura Cimino, Maria Rita Gulotta, Giada De Simone, Maria Agnese Morando, Raffaele Sabbatella, Simona Di Martino, Mario Fogazza, Federica Sarno, Claudia Coronnello, Maria De Rosa, Chiara Cipollina, Lucia Altucci, Ugo Perricone, Caterina Alfano
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background Lysine demethylase enzymes (KDMs) are an emerging class of therapeutic targets, that catalyse the removal of methyl marks from histone lysine residues regulating chromatin structure and gene expression. KDM4A isoform plays an impo
Externí odkaz:
https://doaj.org/article/b96d859348f0461a9deca1a52950e217
Autor:
Liliana Montella, Carmela Dell’Aversana, Daniela Pacella, Simona Troise, Paola Russo, Valentina Cacciapuoti, Alessandro Ottaiano, Luigi Di Marino, Paola Coppola, Carmela Liguori, Massimiliano Berretta, Salvatore Maddaluno, Lucia Altucci, Gaetano Facchini
Publikováno v:
Infectious Agents and Cancer, Vol 18, Iss 1, Pp 1-10 (2023)
Abstract SARS-CoV-2 vaccination is strongly recommended, particularly for fragile patients such as those undergoing active oncological treatments. It is crucial to conduct post-marketing surveillance in this patient population. In our study, we condu
Externí odkaz:
https://doaj.org/article/ee0a0ef8998b42edb00060d890077729
Autor:
Catarina Macedo-Silva, Vera Miranda-Gonçalves, Nuno Tiago Tavares, Daniela Barros-Silva, Joana Lencart, João Lobo, Ângelo Oliveira, Margareta P. Correia, Lucia Altucci, Carmen Jerónimo
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-13 (2023)
Abstract External beam radiotherapy (RT) is a leading first-line therapy for prostate cancer (PCa), and, in recent years, significant advances have been accomplished. However, RT resistance can arise and result in long-term recurrence or disease prog
Externí odkaz:
https://doaj.org/article/65286e906b2b4ab4ae73151352e131b7
Autor:
Lucia Scisciola, Ugo Chianese, Vicky Caponigro, Manuela Giovanna Basilicata, Emanuela Salviati, Lucia Altucci, Pietro Campiglia, Giuseppe Paolisso, Michelangela Barbieri, Rosaria Benedetti, Eduardo Sommella
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Sodium–glucose cotransporter 2 (SGLT2) inhibitors constitute the gold standard treatment for type 2 diabetes mellitus (T2DM). Among them, empagliflozin (EMPA) has shown beneficial effects against heart failure. Because cardiovas
Externí odkaz:
https://doaj.org/article/f9085a4fe01747819d1ef129d4319709
Autor:
Benluvankar Varghese, Ugo Chianese, Lucia Capasso, Veronica Sian, Paola Bontempo, Mariarosaria Conte, Rosaria Benedetti, Lucia Altucci, Vincenzo Carafa, Angela Nebbioso
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Cancer cells are characterized by uncontrolled cell proliferation and impaired bioenergetics. Sirtuins are a family of highly conserved enzymes that play a fundamental role in energy metabolism regulation. SIRT1, in particular, dr
Externí odkaz:
https://doaj.org/article/fc21522b9cb640cb8ae0a88b393f320a