Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Lucia, Toporova"'
Autor:
Zdeněk Dvořák, Felix Kopp, Cait M Costello, Jazmin S Kemp, Hao Li, Aneta Vrzalová, Martina Štěpánková, Iveta Bartoňková, Eva Jiskrová, Karolína Poulíková, Barbora Vyhlídalová, Lars U Nordstroem, Chamini V Karunaratne, Harmit S Ranhotra, Kyu Shik Mun, Anjaparavanda P Naren, Iain A Murray, Gary H Perdew, Julius Brtko, Lucia Toporova, Arne Schön, Bret D Wallace, William G Walton, Matthew R Redinbo, Katherine Sun, Amanda Beck, Sandhya Kortagere, Michelle C Neary, Aneesh Chandran, Saraswathi Vishveshwara, Maria M Cavalluzzi, Giovanni Lentini, Julia Yue Cui, Haiwei Gu, John C March, Shirshendu Chatterjee, Adam Matson, Dennis Wright, Kyle L Flannigan, Simon A Hirota, Ryan Balfour Sartor, Sridhar Mani
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 4, Pp 1-19 (2020)
Abstract The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have substantial off‐target toxicity. Based on prior work that esta
Externí odkaz:
https://doaj.org/article/3bc1d75f8f9149f2b831e9fe3ca8d3bb
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
To characterize human nuclear receptor (NR) specificity of synthetic pharmaceutical chemicals we established stable cell lines expressing the ligand binding domains (LBDs) of human FXR, LXRα, LXRβ, CAR, and RORγ fused to the yeast GAL4 DNA binding
Externí odkaz:
https://doaj.org/article/4b21079a072545a4930acc0cdd800cab
Autor:
Nicolas Creusot, Matthieu Gassiot, Elina Alaterre, Barbara Chiavarina, Marina Grimaldi, Abdelhay Boulahtouf, Lucia Toporova, Sabine Gerbal-Chaloin, Martine Daujat-Chavanieu, Alice Matheux, Roger Rahmani, Céline Gongora, Alexandre Evrard, Philippe Pourquier, Patrick Balaguer
Publikováno v:
Cells, Vol 9, Iss 7, p 1641 (2020)
The human pregnane X receptor (hPXR) is activated by a large set of endogenous and exogenous compounds and plays a critical role in the control of detoxifying enzymes and transporters regulating liver and gastrointestinal drug metabolism and clearanc
Externí odkaz:
https://doaj.org/article/6365fd85f5794b0ba04d7fe248f966dc
Autor:
Clémentine, Garoche, Abdelhay, Boulahtouf, Marina, Grimaldi, Barbara, Chiavarina, Lucia, Toporova, Marjo J, den Broeder, Juliette, Legler, William, Bourguet, Patrick, Balaguer
Publikováno v:
Environmental sciencetechnology. 55(24)
Endocrine disrupting chemicals (EDCs) are able to deregulate the hormone system, notably through interactions with nuclear receptors (NRs). The mechanisms of action and biological effects of many EDCs have mainly been tested on human and mouse but ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e4b72ae6116579ba20738ca889828d70
https://pubmed.ncbi.nlm.nih.gov/34843233
https://pubmed.ncbi.nlm.nih.gov/34843233
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Frontiers in Pharmacology
Frontiers in Pharmacology
To characterize human nuclear receptor (NR) specificity of synthetic pharmaceutical chemicals we established stable cell lines expressing the ligand binding domains (LBDs) of human FXR, LXRα, LXRβ, CAR, and RORγ fused to the yeast GAL4 DNA binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdffbec841ece35d005908cfb1da1a1c
https://www.frontiersin.org/article/10.3389/fphar.2020.01122/full
https://www.frontiersin.org/article/10.3389/fphar.2020.01122/full
Autor:
Julius Brtko, Dana Macejova, Dana Strouhalova, Janette Bobalova, Lucia Toporova, Markéta Laštovičková
Publikováno v:
General physiology and biophysics. 38:135-144
Trialkyltins and triaryltins function as nuclear retinoid X receptors (RXR) agonists due to their affinity to the ligand-binding domain of RXR subtypes and function as transcriptional activators. We present the data on combined effects of all-trans r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe3d7fdab5218a0e21a606f52b89a1b
https://doi.org/10.4149/gpb_2018042
https://doi.org/10.4149/gpb_2018042
Autor:
Chamini V. Karunaratne, Arne Schön, Iain A. Murray, Michelle C. Neary, Maria Maddalena Cavalluzzi, Matthew R. Redinbo, Adam P. Matson, Bret D. Wallace, Gary H. Perdew, Martina Stepankova, Ryan Balfour Sartor, Eva Jiskrová, Saraswathi Vishveshwara, Shirshendu Chatterjee, Dennis L. Wright, Zdeněk Dvořák, Haiwei Gu, Kyu Shik Mun, John C. March, Simon A. Hirota, Julia Yue Cui, Katherine Sun, Lars U. Nordstroem, Amanda P. Beck, Iveta Iveta Bartonkov, Aneta Vrzalová, Julius Brtko, Barbora Vyhlídalová, Sridhar Mani, Kyle L. Flannigan, Karolína Poulíková, Felix Kopp, Hao Li, Lucia Toporova, Harmit S. Ranhotra, William G. Walton, Cait M. Costello, Sandhya Kortagere, Aneesh Chandran, Giovanni Lentini, Anjaparavanda P. Naren, Jazmin S. Kemp
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 4, Pp n/a-n/a (2020)
EMBO Molecular Medicine
EMBO Molecular Medicine
The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have substantial off‐target toxicity. Based on prior work that established m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e9267d258ba26f43500c0c8a143511
https://doaj.org/article/3bc1d75f8f9149f2b831e9fe3ca8d3bb
https://doaj.org/article/3bc1d75f8f9149f2b831e9fe3ca8d3bb
Autor:
Lucia Toporova, Patrick Balaguer
Publikováno v:
Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology, Elsevier, 2020, 502, pp.110665. ⟨10.1016/j.mce.2019.110665⟩
Molecular and Cellular Endocrinology, Elsevier, 2020, 502, pp.110665-. ⟨10.1016/j.mce.2019.110665⟩
Molecular and Cellular Endocrinology, Elsevier, 2020, 502, pp.110665. ⟨10.1016/j.mce.2019.110665⟩
Molecular and Cellular Endocrinology, Elsevier, 2020, 502, pp.110665-. ⟨10.1016/j.mce.2019.110665⟩
International audience; Endocrine disrupting chemicals (EDCs) are exogenous substances that are suspected to cause adverse effects in the endocrine system mainly by acting through their interaction with nuclear receptors such as the estrogen receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233159c82aff2077ad2543e2b8e1f537
https://hal.archives-ouvertes.fr/hal-03488727/file/S0303720719303673.pdf
https://hal.archives-ouvertes.fr/hal-03488727/file/S0303720719303673.pdf
Autor:
Alexandre Evrard, Abdelhay Boulahtouf, Marina Grimaldi, Barbara Chiavarina, Matthieu Gassiot, Elina Alaterre, Alice Matheux, Céline Gongora, Lucia Toporova, Philippe Pourquier, Roger Rahmani, Sabine Gerbal-Chaloin, Nicolas Creusot, Martine Daujat-Chavanieu, Patrick Balaguer
Publikováno v:
Cells
Cells, 2020, 9 (7), pp.1641. ⟨10.3390/cells9071641⟩
Cells, MDPI, 2020, 9 (7), pp.1641. ⟨10.3390/cells9071641⟩
Volume 9
Issue 7
Cells, Vol 9, Iss 1641, p 1641 (2020)
Cells, 2020, 9 (7), pp.1641. ⟨10.3390/cells9071641⟩
Cells, MDPI, 2020, 9 (7), pp.1641. ⟨10.3390/cells9071641⟩
Volume 9
Issue 7
Cells, Vol 9, Iss 1641, p 1641 (2020)
The human pregnane X receptor (hPXR) is activated by a large set of endogenous and exogenous compounds and plays a critical role in the control of detoxifying enzymes and transporters regulating liver and gastrointestinal drug metabolism and clearanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b2fd55d9bc59d5375341acd5066e85
https://hal.inrae.fr/hal-02899508/document
https://hal.inrae.fr/hal-02899508/document
Autor:
Dana Macejova, Karol Kajo, Julius Brtko, Katarina Machalekova, Marianna Grigerova, Jan Podoba, Lucia Toporova
Potential causal associations of autoimmune thyroiditis (AIT) and papillary thyroid carcinoma (PTC) have been studied previously. The mRNA expression patterns of thyroid hormone receptors (TR), retinoid receptors (RAR), rexinoid receptors (RXR), dihy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3bebc2bd6fc5dff428cbaad1f8e1be9
https://europepmc.org/articles/PMC6757255/
https://europepmc.org/articles/PMC6757255/