Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lucia, Taraborrelli"'
Autor:
Lucia Taraborrelli, Yasin Şenbabaoğlu, Lifen Wang, Junghyun Lim, Kerrigan Blake, Noelyn Kljavin, Sarah Gierke, Alexis Scherl, James Ziai, Erin McNamara, Mark Owyong, Shilpa Rao, Aslihan Karabacak Calviello, Daniel Oreper, Suchit Jhunjhunwala, Guillem Argiles, Johanna Bendell, Tae Won Kim, Fortunato Ciardiello, Matthew J. Wongchenko, Frederic J. de Sauvage, Felipe de Sousa e Melo, Yibing Yan, Nathaniel R. West, Aditya Murthy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Microsatellite-stable colorectal cancer (MSS-CRC) is highly refractory to immunotherapy. Understanding tumor-intrinsic determinants of immunotherapy resistance is critical to improve MSS-CRC patient outcomes. Here, we demonstrate that high t
Externí odkaz:
https://doaj.org/article/60a294e8ef9e4b37a641c0c3e8919afe
Autor:
Lucia Taraborrelli, Nieves Peltzer, Antonella Montinaro, Sebastian Kupka, Eva Rieser, Torsten Hartwig, Aida Sarr, Maurice Darding, Peter Draber, Tobias L. Haas, Ayse Akarca, Teresa Marafioti, Manolis Pasparakis, John Bertin, Peter J. Gough, Philippe Bouillet, Andreas Strasser, Martin Leverkus, John Silke, Henning Walczak
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
TNF mediated inflammation is critical in autoimmune mediated pathology, however many patients are refractory to current anti-TNF therapeutics. Here the authors show induction of several death ligands, in addition to TNF is sufficient to cause fatal d
Externí odkaz:
https://doaj.org/article/78dd2d56aa01420b8690887b14510d40
Autor:
Peter Draber, Sebastian Kupka, Matthias Reichert, Helena Draberova, Elodie Lafont, Diego de Miguel, Lisanne Spilgies, Silvia Surinova, Lucia Taraborrelli, Torsten Hartwig, Eva Rieser, Luigi Martino, Katrin Rittinger, Henning Walczak
Publikováno v:
Cell Reports, Vol 13, Iss 10, Pp 2258-2272 (2015)
Ubiquitination and deubiquitination are crucial for assembly and disassembly of signaling complexes. LUBAC-generated linear (M1) ubiquitin is important for signaling via various immune receptors. We show here that the deubiquitinases CYLD and A20, bu
Externí odkaz:
https://doaj.org/article/6c17437bc05345f6a259e00153b83b21
Autor:
Nieves Peltzer, Eva Rieser, Lucia Taraborrelli, Peter Draber, Maurice Darding, Barbara Pernaute, Yutaka Shimizu, Aida Sarr, Helena Draberova, Antonella Montinaro, Juan Pedro Martinez-Barbera, John Silke, Tristan A. Rodriguez, Henning Walczak
Publikováno v:
Cell Reports, Vol 9, Iss 1, Pp 153-165 (2014)
Summary: Linear ubiquitination is crucial for innate and adaptive immunity. The linear ubiquitin chain assembly complex (LUBAC), consisting of HOIL-1, HOIP, and SHARPIN, is the only known ubiquitin ligase that generates linear ubiquitin linkages. HOI
Externí odkaz:
https://doaj.org/article/fe44decd3f4d43868515aa18741bdad2
Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency
Autor:
Andrew Oberst, Karen Blyth, Alba Roca, Nader Yatim, Simon Milling, Laura M. Machesky, Barbara Zunino, Matthew L. Albert, Camila Rubio-Patiño, Stephen W.G. Tait, Nieves Peltzer, Loic Fort, Kai Cao, Emma Proïcs, Jonathan Lopez, Sandeep Dhayade, Florian J. Bock, Gabriel Ichim, Daniele Lecis, Jean-Ehrland Ricci, Catherine Cloix, Lucia Taraborrelli, Susana Orozco, Emma F. Woodham, Kevin M. Ryan, Evangelos Giampazolias, Henning Walczak
Publikováno v:
Nature cell biology
Apoptosis represents a key anti-cancer therapeutic effector mechanism. During apoptosis, mitochondrial outer membrane permeabilisation (MOMP) typically kills cells even in the absence of caspase activity. Caspase activity can also have a variety of u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3482fbfe4edc9c8f23ecc380e47aba0
https://doi.org/10.1038/ncb3596
https://doi.org/10.1038/ncb3596
Autor:
Cecile de la Cruz, Patrick J. Lupardus, Zhiyuan Fan, Lucia Taraborrelli, Richard Bourgon, Ira Mellman, Manmeet Singh, Samuel B. Pollock, Jennie R. Lill, Jim K. Wong, James Cevallos, Nicolas Lounsbury, Yajun Chestnut, Tamaki Nozawa, Lélia Delamarre, Benjamin Haley, Ajay Fernandez, Qui T. Phung, Lena Hänsch, Aude-Hélène Capietto, Suchit Jhunjhunwala
Publikováno v:
The Journal of Experimental Medicine
Cancer mutations create neoantigens that are of great interest for immunotherapy, but their accurate identification remains a challenge. Capietto et al. show that mutation position is an important determinant for immunogenicity, and incorporating thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aaa8a23f2bbe5a75d6e3e4f56a8bf6f
https://pubmed.ncbi.nlm.nih.gov/31940002
https://pubmed.ncbi.nlm.nih.gov/31940002
Autor:
Eva Rieser, Lucia Taraborrelli, Henning Walczak, Torsten Hartwig, Silvia von Karstedt, Cornelia Endres, Brian J. Ferguson, Julia Zinngrebe, Johannes Lemke, Ildiko Kovacs, Maurice Darding, Peter Draber, Nieves Peltzer, Michael Bergmann, Balazs Dome, Hongwei Ren
Publikováno v:
Journal of Experimental Medicine
The Journal of Experimental Medicine
The Journal of Experimental Medicine
LUBAC components interact with the TLR3 signaling cascade at different levels, thereby tightly controlling TLR3-mediated innate immunity.
The linear ubiquitin chain assembly complex (LUBAC), consisting of SHANK-associated RH-domain–interacting
The linear ubiquitin chain assembly complex (LUBAC), consisting of SHANK-associated RH-domain–interacting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4b1b9585a2616a2801f5d1e7e978e1
https://doi.org/10.1084/jem.20160041
https://doi.org/10.1084/jem.20160041
Autor:
Ayse U. Akarca, Sebastian Kupka, Andreas Strasser, Nieves Peltzer, Eva Rieser, Tobias L. Haas, Torsten Hartwig, Lucia Taraborrelli, Manolis Pasparakis, Martin Leverkus, Philippe Bouillet, Peter Draber, John Silke, Maurice Darding, Henning Walczak, Peter J. Gough, Teresa Marafioti, Aida Sarr, Antonella Montinaro, John Bertin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications 9, 3910 (2018). doi:10.1038/s41467-018-06155-8
Nature Communications 9, 3910 (2018). doi:10.1038/s41467-018-06155-8
The linear ubiquitin chain assembly complex (LUBAC), composed of HOIP, HOIL-1 and SHARPIN, is required for optimal TNF-mediated gene activation and to prevent cell death induced by TNF. Here, we demonstrate that keratinocyte-specific deletion of HOIP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b8112879eec8e8dc449c0d37601286
https://pubmed.ncbi.nlm.nih.gov/30254289
https://pubmed.ncbi.nlm.nih.gov/30254289
Autor:
Torsten Hartwig, Sebastian Kupka, Helena Draberova, Matthias Reichert, Lucia Taraborrelli, Eva Rieser, Elodie Lafont, Henning Walczak, Diego de Miguel, Peter Draber, Katrin Rittinger, Lisanne Spilgies, Luigi Martino, Silvia Surinova
Publikováno v:
Cell Reports
Cell Reports, Vol 13, Iss 10, Pp 2258-2272 (2015)
Cell Reports, Vol 13, Iss 10, Pp 2258-2272 (2015)
Summary Ubiquitination and deubiquitination are crucial for assembly and disassembly of signaling complexes. LUBAC-generated linear (M1) ubiquitin is important for signaling via various immune receptors. We show here that the deubiquitinases CYLD and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0eeab16ff3b54ecc6463e1bfb0a77f
https://doi.org/10.1016/j.celrep.2015.11.009
https://doi.org/10.1016/j.celrep.2015.11.009
Autor:
Elodie, Lafont, Chahrazade, Kantari-Mimoun, Peter, Draber, Diego, De Miguel, Torsten, Hartwig, Matthias, Reichert, Sebastian, Kupka, Yutaka, Shimizu, Lucia, Taraborrelli, Maureen, Spit, Martin R, Sprick, Henning, Walczak
Publikováno v:
The EMBO journal. 36(9)
TNF receptor‐1 (TNFR1) and TRAIL death receptors preferentially induce pro‐inflammatory or cytotoxic signaling, respectively, via distinct plasma membrane and cytosolic complexes. New studies identifying the pro‐inflammatory factors TRAF2, RIP,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::307921ca7fcf85ab1319e44ccd41204f
https://pubmed.ncbi.nlm.nih.gov/28400401
https://pubmed.ncbi.nlm.nih.gov/28400401